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Electrospun Antimicrobial Wound Dressings: Novel Strategies to Fight Against Wound Infections

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Chronic Wounds, Wound Dressings and Wound Healing

Part of the book series: Recent Clinical Techniques, Results, and Research in Wounds ((RCTRRW,volume 6))

Abstract

Antimicrobial drug-loaded electrospun nano-/microfibrous mats are of major interest as wound dressings for effective wound care. Treatment of wound infection is a crucial part of the therapy, and high bioburden leading to persistent infections and systemic toxicity are an increasing antibiotic-related problems. It is evident that biofilm plays a significant role in the development of hard-to-heal chronic wounds, and therefore novel strategies to fight against microbial biofilms are of relevance. In most cases, the selection of an appropriate antimicrobial agent becomes a critical factor. There is an increasing interest to develop antimicrobial bioactive wound dressings which are not only used to remove the microbes but also to interact with the wound and support the normal wound healing. In order to develop such dressings using electrospinning technology, several important properties need to be investigated which enable to understand the dressings and their potential applications for effectively treating the wound infection.

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Acknowledgments

Financial support by personal research project no. PUT1088. The Estonian Science Foundation and Estonian Ministry of Education and Research are thanked for funding.

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  1. Institute of Pharmacy, University of Tartu, Tartu, Estonia

    Liis Preem & Karin Kogermann

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  1. Liis Preem
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Correspondence to Karin Kogermann .

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  1. Tustin, CA, USA

    Melvin A. Shiffman

  2. Newport Beach, CA, USA

    Mervin Low

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Preem, L., Kogermann, K. (2018). Electrospun Antimicrobial Wound Dressings: Novel Strategies to Fight Against Wound Infections. In: Shiffman, M., Low, M. (eds) Chronic Wounds, Wound Dressings and Wound Healing. Recent Clinical Techniques, Results, and Research in Wounds, vol 6. Springer, Cham. https://doi.org/10.1007/15695_2018_133

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  • DOI: https://doi.org/10.1007/15695_2018_133

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