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Polymeric Systems for Bioinspired Delivery of Angiogenic Molecules

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Polymers for Regenerative Medicine

Part of the book series: Advances in Polymer Science ((POLYMER,volume 203))

Abstract

Growth factors are increasingly utilized to promote regeneration of lost or compromised tissues and organs. However, current strategies applying growth factors by bolus injections typically fail to restore tissue functions. Delivery from polymeric systems may overcome this limitation by supplying growth factors in a well-controlled, localized, and sustained manner to the defect site. Traditional polymeric delivery vehicles have been developed based on physicochemical design variables; however, it has now become clear that the appropriate mimicry of certain biologic signaling events may be necessary to achieve full function from the delivered growth factors. Because of its central importance in the development and regeneration of various tissues (e.g., blood vessels, bone, and nerves) bioinspired VEGF supply may be particularly useful to successfully restore tissue functions. Following a brief overview of VEGF's biology, design attributes for polymeric systems for VEGF delivery will be discussed, and subsequently illustrated in the context of three specific applications: therapeutic angiogenesis, bone regeneration, and nerve regeneration.

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Abbreviations

Ang-1:

angiopoietin-1

Ang-2:

angiopoietin-2

bFGF:

basic fibroblast growth factor

BMP-2:

bone morphogenetic protein-2

3-D:

three-dimensional

ECM:

extracellular matrix

G:

alpha-L-guluronic acid

LCST:

lower critical solution temperature

M:

beta-D-mannuronic acid

MW:

molecular weight

MMP:

matrix metalloproteinase

NGF:

nerve growth factor

NRP:

neuropilin

PAA:

poly(acrylic acid)

PDGF:

platelet derived growth factor

PEG:

poly(ethylene glycol)

PEI:

poly(ethylenimine)

PGA:

poly(glycolic acid)

PLA:

poly(lactic acid)

PLGA:

poly(lactic-co-glycolic acid)

PNIPAAm:

poly(N-isopropylacrylamide)

PPE-EA:

polyaminoethyl propylene phosphate

RGD:

arginine-glycine-aspartic acid

GRGD:

glycine-arginine-aspartic acid

T g :

glass transition temperature

TGF-beta:

transforming growth factor-beta

VEGF:

vascular endothelial growth factor

VEGF-R:

vascular endothelial growth factor receptor

VPF:

vascular permeability factor

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Authors and Affiliations

  1. Division of Engineering and Applied Sciences, Harvard University, Room 325 Pierce Hall, 29 Oxford Street, 02138, Cambridge, MA, USA

    Claudia Fischbach & David J. Mooney

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  1. Claudia Fischbach
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  2. David J. Mooney
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Correspondence to David J. Mooney .

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Carsten Werner

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Fischbach, C., Mooney, D.J. Polymeric Systems for Bioinspired Delivery of Angiogenic Molecules. In: Werner, C. (eds) Polymers for Regenerative Medicine. Advances in Polymer Science, vol 203. Springer, Berlin, Heidelberg. https://doi.org/10.1007/12_070

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