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Advances of MALDI-TOF MS in the Analysis of Traditional Chinese Medicines

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Applications of MALDI-TOF Spectroscopy

Part of the book series: Topics in Current Chemistry ((TOPCURRCHEM,volume 331))

Abstract

Traditional Chinese medicines (TCMs) are attracting more and more attention because of their long historical clinical experience and reliable therapeutic efficacy for preventing and/or treating various human diseases. Many techniques and methods were developed for the analysis of TCMs to support new drug discovery and quality control. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS), a soft ionization mass spectrometric technique, has been widely used in the analysis of a wide variety of large molecular compounds including proteins, peptides, and polymers since it was introduced in the late 1980s. In the present chapter, advances of MALDI-TOF MS in TCMs analysis have been reviewed. The review covers MALDI-TOF MS applications in the identification of new bioactive ingredients, analysis of alkaloids, determination of small molecular compounds with new matrices, proteomics analysis associated with TCMs, direct analysis of plant tissue, and other applications in TCMs.

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Abbreviations

2-DE:

Two-dimensional gel electrophoresis

α-CHCA:

α-Cyano-4-hydroxycinnamic acid

DHB:

2,5-Dihydroxybenzoic acid

ESI:

Electrospray ionization

HPLC:

High performance liquid chromatography

IEC:

Ion exchange chromatography

MALDI:

Matrix-assisted laser desorption/ionization

MS:

Mass spectrometry

TCMs:

Traditional Chinese medicines

TLC:

Thin-layer chromatography

TOF:

Time-of-flight

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Acknowledgements

We are thankful for the financial support from the National Nature Sciences Foundation of China (No. 20928005 and 21175025)

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Authors and Affiliations

  1. Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Kowloon, Hong Kong SAR, China

    Minghua Lu & Zongwei Cai

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  1. Minghua Lu
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  2. Zongwei Cai
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Correspondence to Zongwei Cai .

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Editors and Affiliations

  1. , Department of Chemistry, Hong Kong Baptist University, Ho Sin Hang Campus, Hong Kong, 000000000, China, People's Republic

    Zongwei Cai

  2. , Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 000000000, China, People's Republic

    Shuying Liu

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Lu, M., Cai, Z. (2012). Advances of MALDI-TOF MS in the Analysis of Traditional Chinese Medicines. In: Cai, Z., Liu, S. (eds) Applications of MALDI-TOF Spectroscopy. Topics in Current Chemistry, vol 331. Springer, Berlin, Heidelberg. https://doi.org/10.1007/128_2012_383

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