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Bioinformatic Analysis of Data Generated from MALDI Mass Spectrometry for Biomarker Discovery

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Applications of MALDI-TOF Spectroscopy

Part of the book series: Topics in Current Chemistry ((TOPCURRCHEM,volume 331))

Abstract

In this chapter we first describe the applications of matrix-assisted laser desorption/ionization (MALDI) mass spectrometry (MS) in biomarker discovery. After a summary of the general analysis pipeline of MALDI MS data, each step of the pipeline will be elaborated in detail. In particular we try to provide a categorization of existing solutions with the hope that the reader can obtain a global picture on this topic. In addition we show how to apply such an analysis pipeline in protein and glycan profiling for biomarker discovery and for a deeper understanding of diseases. Finally we discuss the limitations of current analysis methods and the perspectives of future research.

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Acknowledgements

This work was partially supported by the Natural Science Foundation of China under Grant No. 61003176, the General Research Fund 621707 and 662509 from the Hong Kong Research Grant Council, the Area of Excellence Scheme and Special Equipment Grant from the University Grants Committee of Hong Kong, and the Research Proposal Competition Awards RPC07/08.EG25 and RPC10.EG04 from the Hong Kong University of Science and Technology.

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Authors and Affiliations

  1. School of Software, Dalian University of Technology, Dalian, China

    Zengyou He

  2. Division of Life Science and State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Hong Kong, China

    Robert Z. Qi

  3. Department of Electronic and Computer Engineering, The Hong Kong University of Science and Technology, Hong Kong, China

    Weichuan Yu

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  1. Zengyou He
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  2. Robert Z. Qi
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  3. Weichuan Yu
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Correspondence to Zengyou He .

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Editors and Affiliations

  1. , Department of Chemistry, Hong Kong Baptist University, Ho Sin Hang Campus, Hong Kong, 000000000, China, People's Republic

    Zongwei Cai

  2. , Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 000000000, China, People's Republic

    Shuying Liu

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© 2012 Springer-Verlag Berlin Heidelberg

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He, Z., Qi, R.Z., Yu, W. (2012). Bioinformatic Analysis of Data Generated from MALDI Mass Spectrometry for Biomarker Discovery. In: Cai, Z., Liu, S. (eds) Applications of MALDI-TOF Spectroscopy. Topics in Current Chemistry, vol 331. Springer, Berlin, Heidelberg. https://doi.org/10.1007/128_2012_365

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