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Chemical and Biochemical Applications of MALDI TOF-MS Based on Analyzing the Small Organic Compounds

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Applications of MALDI-TOF Spectroscopy

Part of the book series: Topics in Current Chemistry ((TOPCURRCHEM,volume 331))

Abstract

This review focuses on the recent applications of matrix-assisted laser desorption ionization time of flight mass spectrometry (MALDI TOF-MS) technologies for analysis of small molecular compounds (SMCs) on qualitative and quantitative levels to provide valuable information for the relative chemical and biochemical researches. We summarized the approaches to minimize the interference in low m/z range and ion suppression effects by adding chemical reagents, sample cleaning and preparation, matrix selection and performing chromatographic separation before MALDI TOF-MS analysis. Meanwhile, we discussed the strategies to enhance the MALDI TOF-MS detection sensitivity and selectivity by derivatization to attach the “charge tags” to SMCs. In addition, the mass spectrometric imaging (MSI) methods for locating the target SMCs in bio-tissues by MALDI TOF-MS were reviewed. Furthermore, the applications of MALDI TOF-MS for monitoring enzyme reactions and the screening of their inhibitors were also presented. Finally, the chemical applications of MALDI TOF-MS on characterization of small molecular transition-metal complexes and monitoring the organic reactions, especially the polymerization reactions, were discussed.

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Abbreviations

AChE:

Acetylcholinesterase

CAD:

Collision-activated dissociation

CHCA:

α-Cyano-4-hydroxycinnamic acid

CID:

Collision-induced dissociation

CNTs:

Oxidized carbon nanotubes

CT:

Charge-transfer ionization

DCTB:

2-[(2E)-3-4-(tert-butylphenyl)-2-methylprop-2-enylidene] malononitrile

DHB:

2,5-Dihydroxybenzoic acid

DIOS:

Desorption/ionization on silicon

ESI:

Electrospray ionization

FTICR-MS:

Fourier transform ion cyclotron resonance mass spectrometry

LC:

Liquid chromatography

MALDI:

Matrix assisted laser desorption ionization

MS:

Mass spectrometry or mass spectrometer

MS/MS:

Tandem mass spectrometry

MSI:

Mass spectrometric imaging

NALDI:

Nano-assisted laser desorption–ionization

NAPIQ:

N-alkylpyridinium isotope quaternization

SALDI:

Surface-assisted laser desorption/ionization

SMCs:

Small molecular compounds

SRM:

Selected ion reaction monitoring

TLC:

Thin layer chromatography

TOF-MS:

Time-of-flight mass spectrometer

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Acknowledgments

The authors express great thanks to Prof. Dr. Deryn E. Fogg in University of Ottawa and Jürgen Schiller in Universität Leipzig for their generosity and for kindly providing their publications. The authors acknowledge financial support from NSFC (20902104, 21072215, and 21172250), Innovation Method Fund of China (2010IM030900), and CAS (YZ200938, YG2010056).

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Authors and Affiliations

  1. Shanghai Mass Spectrometry Center, Shanghai Institute of Organic Chemistry, Chinese Academy of Science, LingLing Road 345, 200032, Shanghai, People’s Republic of China

    Haoyang Wang, Zhixiong Zhao & Yinlong Guo

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  1. Haoyang Wang
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  2. Zhixiong Zhao
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  3. Yinlong Guo
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Correspondence to Haoyang Wang .

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  1. , Department of Chemistry, Hong Kong Baptist University, Ho Sin Hang Campus, Hong Kong, 000000000, China, People's Republic

    Zongwei Cai

  2. , Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 000000000, China, People's Republic

    Shuying Liu

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Wang, H., Zhao, Z., Guo, Y. (2012). Chemical and Biochemical Applications of MALDI TOF-MS Based on Analyzing the Small Organic Compounds. In: Cai, Z., Liu, S. (eds) Applications of MALDI-TOF Spectroscopy. Topics in Current Chemistry, vol 331. Springer, Berlin, Heidelberg. https://doi.org/10.1007/128_2012_364

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