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Biosensors in Microfluidic Chips

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Microfluidics

Part of the book series: Topics in Current Chemistry ((TOPCURRCHEM,volume 304))

Abstract

A biosensor is a sensing device that incorporates a biological sensing element and a transducer to produce electrochemical, optical, mass, or other signals in proportion to quantitative information about the analytes in the given samples. The microfluidic chip is an attractive miniaturized platform with valuable advantages, e.g., low cost analysis requiring low reagent consumption, reduced sample volume, and shortened processing time. Combination of biosensors and microfluidic chips enhances analytical capability so as to widen the scope of possible applications. This review provides an overview of recent research activities in the field of biosensors integrated on microfluidic chips, focusing on the working principles, characteristics, and applicability of the biosensors. Theoretical background and applications in chemical, biological, and clinical analysis are summarized and discussed.

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Abbreviations

PSA:

Prostate-specific antigen

TFT:

Thin film transistor

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Acknowledgments

The authors acknowledge Mid-career Researcher Program through the NRF (National Research Foundation) grant funded by the MEST (Ministry of Education, Science and Technology) of Korea (No. 2010-0011751), the Public welfare & Safety research program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (No. 2010-0020772), and the Converging Research Center Program through the Ministry of Education, Science and Technology (2010K001297).

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Authors and Affiliations

  1. Interdisciplinary Program, Biomedical Engineering Major, Graduate School, Seoul National University, Seoul, Korea

    Jongmin Noh

  2. Department of Biomedical Engineering, College of Medicine and Institute of Medical and Biological Engineering, Medical Research Center, Seoul National University, Seoul, Korea

    Hee Chan Kim

  3. Department of Chemistry, Seoul National University, Seoul, Korea

    Taek Dong Chung

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  1. Jongmin Noh
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Correspondence to Taek Dong Chung .

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  1. The Chinese Academy of Sciences, Laboratory of Biotechnology, Dalian Institute of Chemical Physics, ZhongShan Road 457, Dalian, 116023, China, People's Republic

    Bingcheng Lin

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Noh, J., Kim, H.C., Chung, T.D. (2011). Biosensors in Microfluidic Chips. In: Lin, B. (eds) Microfluidics. Topics in Current Chemistry, vol 304. Springer, Berlin, Heidelberg. https://doi.org/10.1007/128_2011_143

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