Abstract
This review covers synthetic pores as sensors, an interdisciplinary topic that may appeal not only to bioorganic and supramolecular but also to analytical, organic, or physical chemists. In the introduction, fundamental concepts and methods are briefly reiterated. The next section introduces synthetic pores as multifunctional supramolecules that are created from abiotic scaffolds and act in lipid bilayer membranes. Then follows the introduction of the concept of synthetic multifunctional pores as general optical transducers of chemical reactions. For this purpose, synthetic pores that recognize small changes in bulk and/or charge of as many substrates and products as possible are best, and internal π-clamps are added to catch elusive analytes. For multicomponent sensing in complex matrixes, synthetic pores as general transducers are combined with enzymes as specific signal generators. Realized examples of practical applications to samples from the supermarket describe synthetic pores as sensors of sugar in soft drinks. Section 3 focuses on sensing with biological and bioengineered pores. Selected topics, such as general electrical transduction in planar and supported lipid bilayer membranes, the concept of stochastic sensing of single analytes, immunosensing, covalent polynucleotide amplifiers, and single gene sequencing, are briefly spotlighted to also outline future perspectives with synthetic pore sensors. Section 4 briefly covers initial breakthroughs on sensing with synthetic pores in membranes other than lipid bilayers, such as functionalized conical gold and cylindrical carbon nanotubes.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Matile S, Sakai N (2007) The characterization of synthetic ion channels and pores. In: Schalley CA (ed) Analytical methods in supramolecular chemistry. Wiley, Weinheim, pp 391–418
Das G, Talukdar P, Matile S (2002) Science 298:1600–1602
Litvinchuk S, Sordé N, Matile S (2005) J Am Chem Soc 127:9316–9317
Das G, Matile S (2006) Chem Eur J 12:2936–2944
Kramer RH (1990) Neuron 4:335–341
Karlin A, Akabas MH (1998) Methods Enzymol 293:123–145
Mindell JA, Zhan H, Huynh PD, Collier RJ, Finkelstein A (1994) Proc Natl Acad Sci USA 91:5272–5276
Woolley GA, Jaikaran ASI, Zhang Z, Peng S (1995) J Am Chem Soc 117:4448–4454
Kasianowicz JJ, Brandin E, Branton D, Deamer DW (1996) Proc Natl Acad Sci USA 93:13770–13773
Cornell BA, Braach-Maksvytis VLB, King LG, Osman PDJ, Raguse B, Wieczorek L, Pace RJ (1997) Nature 387:580–583
Gu LQ, Braha O, Conlan S, Cheley S, Bayley H (1999) Nature 398:686–690
Fuhrhop JH, Liman U, Koesling V (1988) J Am Chem Soc 110:6840–6845
Sakai N, Majumdar N, Matile S (1999) J Am Chem Soc 121:4294–4295
Sakai N, Baumeister B, Matile S (2000) ChemBioChem 1:123–125
Gorteau V, Perret F, Bollot G, Mareda J, Lazar AN, Coleman AW, Tran DH, Sakai N, Matile S (2004) J Am Chem Soc 126:13592–13593
Bhosale S, Sisson AL, Talukdar P, Fürstenberg A, Banerji N, Vauthey E, Bollot G, Mareda J, Röger C, Würthner F, Sakai N, Matile S (2006) Science 313:84–86
Baumeister B, Sakai N, Matile S (2001) Org Lett 3:4229–4232
Wiskur SL, Anslyn EV (2001) J Am Chem Soc 123:10109–10110
Collins BE, Wright AT, Anslyn EV (2007) Combining Molecular Recognition, Optical Detection, and Chemometric Analysis, in this volume
Clark LC, Lyons C (1962) Ann NY Acad Sci 102:29
Sanz Alaejos M, Garcìa Montelongo FJ (2004) Chem Rev 104:3239–3265
Engvall E (1980) Methods Enzymol 70:419–439
Sakai N, Mareda J, Matile S (2005) Acc Chem Res 38:79–87
Sisson AL, Shah MR, Bhosale S, Matile S (2006) Chem Soc Rev 35:1269–1286
Matile S, Som A, Sordé N (2004) Tetrahedron 60:6405–6435
Gorteau V, Bollot G, Mareda J, Pasini D, Tran DH, Lazar AN, Coleman AW, Sakai N, Matile S (2005) Bioorg Med Chem 13:5171–5180
Kumaki J, Yashima E, Bollot G, Mareda J, Litvinchuk S, Matile S (2005) Angew Chem Int Ed 44:6154–6157
Baumeister B, Sakai N, Matile S (2001) Org Lett 3:4229–4232
Som A, Sakai N, Matile S (2003) Bioorg Med Chem 11:1363–1369
Som A, Matile S (2002) Eur J Org Chem 3874–3883
Tanaka H, Litvinchuk S, Tran DH, Bollot G, Mareda J, Sakai N, Matile S (2006) J Am Chem Soc 128:16000–16001
Litvinchuk S, Matile S (2005) Supramol Chem 17:135–139
Baudry Y, Pasini D, Nishihara M, Sakai N, Matile S (2005) Chem Commun 40:4798–4800
Sordé N, Matile S (2004) Biopolymers 76:55–65
Sordé N, Das G, Matile S (2003) Proc Natl Acad Sci USA 100:11964–11969
Futaki S, Zhang Y, Kiwada T, Nakase I, Yagami T, Oiki S, Sugiura Y (2004) Bioorg Med Chem 12:1343–1350
Terrettaz S, Ulrich WP, Guerrini R, Verdini A, Vogel H (2001) Angew Chem Int Ed 41:1740–1743
Kasianowicz JJ, Henrickson SE, Weetall HH, Robertson B (2001) Anal Chem 73:2268–2272
Oomen CJ, van Ulsen P, van Gelder P, Feijen M, Tommassen J, Gros P (2004) EMBO J 23:1257–1266
Zhang S, Udho E, Wu Z, Collier RJ, Finkelstein A (2004) Biophys J 87:3842–3849
Krantz BA, Melnyk RA, Zhang S, Juris SJ, Lacy DB, Wu Z, Finkelstein A, Collier RJ (2005) Science 309:777–781
Nestorovich E, Danelon C, Wintherhalter M, Bezrukov SM (2002) Proc Natl Acad Sci USA 99:9789–9794
Astier Y, Braha O, Bayley H (2006) J Am Chem Soc 128:1705–1710
Braha O, Gu LQ, Zhou L, Lu X, Cheley S, Bayley H (2000) Nat Biotechnol 18:1005–1007
Cheley S, Gu LQ, Bayley H (2002) Chem Biol 9:829–838
Kang XF, Cheley S, Guan X, Bayley H (2006) J Am Chem Soc 128:10684–10685
Deamer DW, Branton D (2002) Acc Chem Res 35:817–825
Holden MA, Bayley H (2005) J Am Chem Soc 127:6502–6503
Shin SH, Luchian T, Cheley S, Braha O, Bayley H (2002) Angew Chem Int Ed 41:3707–3709
Perret F, Nishihara M, Takeuchi T, Futaki S, Lazar AN, Coleman AW, Sakai N, Matile S (2005) J Am Chem Soc 127:1114–1115
Takeuchi T, Kosuge M, Tadokoro A, Sugiura Y, Nishi M, Kawata M, Sakai N, Matile S, Futaki S (2006) ACS Chem Biol 1:299–303
Miyatake T, Nishihara M, Matile S (2006) J Am Chem Soc 128:12420–12421
Siwy Z, Trofin L, Kohli P, Baker LA, Trautmann C, Martin CR (2005) J Am Chem Soc 127:5000–5001
Harrell CC, Kohli P, Siwy Z, Martin CR (2004) J Am Chem Soc 126:15646–15647
Gyurcsanyi RE, Vigassy T, Pretsch E (2003) Chem Commun 38:2560–2561
Saleh OA, Sohn LL (2003) Proc Natl Acad Sci USA 100:820–824
Carbonaro A, Sohn LL (2005) Lab Chip 5:1155–1156
Majumder M, Chopra N, Andrews R, Hinds BJ (2005) Nature 438:44
Holt J, Park HG, Wang Y, Stadermann M, Artyukin AB, Grigoropoulos CP, Noy A, Bakajin O (2006) Science 312:1034–1040
Majumder M, Chopra N, Hinds BJ (2005) J Am Chem Soc 127:9062–9070
Heins EA, Siwy ZS, Baker LA, Martin CR (2005) Nano Lett 5:1824–1829
Karhanek M, Kemp JT, Pourmand N, Davis RW, Webb CD (2005) Nano Lett 5:403–407
Saleh OA, Sohn LL (2003) Nano Lett 3:37–38
Li J, Stein D, McMullan C, Branton D, Aziz MJ, Golovchenko JA (2001) Nature 412:166–169
Blake S, Mayer T, Mayer M, Yang J (2006) ChemBioChem 7:433–435
Sakai N, Sordé N, Matile S (2003) J Am Chem Soc 125:7776–7777
Author information
Authors and Affiliations
Corresponding author
Editor information
Rights and permissions
Copyright information
© 2007 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Matile, S., Tanaka, H., Litvinchuk, S. (2007). Analyte Sensing Across Membranes with Artificial Pores. In: Schrader, T. (eds) Creative Chemical Sensor Systems. Topics in Current Chemistry, vol 277. Springer, Berlin, Heidelberg. https://doi.org/10.1007/128_2007_113
Download citation
DOI: https://doi.org/10.1007/128_2007_113
Published:
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-71546-7
Online ISBN: 978-3-540-71547-4
eBook Packages: Chemistry and Materials ScienceChemistry and Material Science (R0)