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Hyperforin: To Be or Not to Be an Activator of TRPC(6)

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Reviews of Physiology, Biochemistry and Pharmacology Vol. 169

Part of the book series: Reviews of Physiology, Biochemistry and Pharmacology ((REVIEWS,volume 169))

Abstract

Meantime, it is well accepted that hyperforin, the chemical instable phloroglucinol derivative of Hypericum perforatum, St. John’s wort, is the pharmacophore of St. John’s wort extracts. With the decline of this scientific discussion, another controversial aspect has been arisen, the question regarding the underlying mechanism leading to the pharmacological profile of the plant extract used in therapy of depression. We will summarize the different concepts described for hyperforin’s antidepressive activity. Starting with unspecific protein-independent mechanisms due to changes in pH, we will summarize data of protein-based concepts beginning with concepts based on involvement of a variety of proteins and will finally present concepts based on the modulation of a single protein.

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Authors and Affiliations

  1. Department of Molecular and Clinical Pharmacy, Friedrich-Alexander University Erlangen/Nuremberg, Cauerstr. 4, 91058, Erlangen, Germany

    Kristina Friedland

  2. Institute of Pharmacology and Toxicology and Interfaculty Centre for Pharmacogenomics and Drug Research, Eberhard Karls Universität, Wilhelmstr. 56, 72074, Tübingen, Germany

    Christian Harteneck

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  1. Kristina Friedland
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  2. Christian Harteneck
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Correspondence to Kristina Friedland or Christian Harteneck .

Editor information

Editors and Affiliations

  1. KU Leuven , Leuven, Belgium

    Bernd Nilius

  2. Ludwig-Maximilians-Universität München, Munich, Bayern, Germany

    Thomas Gudermann

  3. Chemistry, Max-Planck-Inst for Biophysical Chemistry, Göttingen, Germany

    Reinhard Jahn

  4. University of Marburg , Marburg, Hessen, Germany

    Roland Lill

  5. Cardiff School of Biosciences, Cardiff University, Cardiff, United Kingdom

    Ole H. Petersen

  6. Loyola University Chicago , MAYWOOD, Illinois, USA

    Pieter P. de Tombe

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Friedland, K., Harteneck, C. (2015). Hyperforin: To Be or Not to Be an Activator of TRPC(6). In: Nilius, B., Gudermann, T., Jahn, R., Lill, R., Petersen, O., de Tombe, P. (eds) Reviews of Physiology, Biochemistry and Pharmacology Vol. 169. Reviews of Physiology, Biochemistry and Pharmacology, vol 169. Springer, Cham. https://doi.org/10.1007/112_2015_25

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