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Scanning Electrochemical Microscopy (SECM) as a Tool in Biosensor Research

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Biosensing for the 21st Century

Part of the book series: Advances in Biochemical Engineering/Biotechnology ((ABE,volume 109))

Abstract

Scanning electrochemical microscopy (SECM) is discussed as a versatile tool to provide localized (electro)chemical information in the context of biosensor research. Advantages of localized electrochemical measurements will be discussed and a brief introduction to SECM and its operation modes will be given. Experimental challenges of the different detection modes of SECM and its applicability for different fields in biosensor research are discussed. Among these are the evaluation of immobilization techniques by probing the local distribution of biological activity, the visualization of diffusion profiles of reactants, cofactors, mediators, and products, and the elucidation of (local) kinetic parameters. The combination of SECM with other scanning-probe techniques allows to maximize the information on a given biosensing system. The potential of SECM as a tool in micro-fabrication aiming for the fabrication of microstructured biosensors will be shortly discussed.

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Authors and Affiliations

  1. Analytische Chemie – Elektroanalytik & Sensorik, Ruhr-University Bochum, Universitätsstr. 150, D-44780, Bochum, Germany

    Leonard Stoica, Sebastian Neugebauer & Wolfgang Schuhmann

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  1. Leonard Stoica
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  2. Sebastian Neugebauer
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  3. Wolfgang Schuhmann
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Correspondence to Wolfgang Schuhmann .

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Reinhard Renneberg Fred Lisdat

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© 2007 Springer-Verlag Berlin Heidelberg

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Stoica, L., Neugebauer, S., Schuhmann, W. (2007). Scanning Electrochemical Microscopy (SECM) as a Tool in Biosensor Research. In: Renneberg, R., Lisdat, F. (eds) Biosensing for the 21st Century. Advances in Biochemical Engineering/Biotechnology, vol 109. Springer, Berlin, Heidelberg. https://doi.org/10.1007/10_2007_082

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