Conclusions
The observations reported here provide a neuroanatomic basis for anterior knee pain syndrome in the young patient and support the clinical observation that the lateral retinaculum may have a key role in the origin of this pain. Our findings, however, do not preclude the possibility of pain arising in other anatomical structures.
We hypothesize that periodic short episodes of ischemia could be implicated in the pathogenesis of anterior knee pain by triggering neural proliferation of nociceptive axons (SP positive nerves), mainly in a perivascular location. Moreover, we believe that instability in patients with anterior knee pain syndrome can be explained, at least in part, because of the damage of nerves of the lateral retinaculum that can be related with proprioception.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Abe, T, DA Morgan, and DD Gutterman. Protective role of nerve growth factor against postischemic dysfunction of sympathetic coronary innervation. Circulation 1997; 95: 213–220.
Abraham, E, E Washington, and TL Huang. Insall proximal realignment for disorders of the patella. Clin Orthop 1989; 248: 61–65.
Ahmed, M, J Bergstrom, H Lundblad et al. Sensory nerves in the interface membrane of aseptic loose hip prostheses. J Bone Joint Surg 1998; 80-B: 151–155.
Alfredson, H, L Ohberg, and S Forsgren. Is vasculo-neural ingrowth the cause of pain in chronic Achilles tendinosis? An investigation using ultrasonography and colour Doppler, immunohistochemistry, and diagnostic injections. Knee Surg Sports Traumatol Arthrosc 2003; 11: 334–338.
Ashton, IK, BA Ashton, SJ Gibson et al. Morphological basis for back pain: the demonstration of nerve fibers and neuropeptides in the lumbar facet joint capsule but not in ligamentum flavum. J Orthop Res 1992; 10: 72–78.
Ashton, IK, S Roberts, and DC Jaffray. Neuropeptides in the human intervertebral disc. J Orthop Res 1994; 12: 186–192.
Ashton, IK, DA Walsh, JM Polak et al. Substance P in intervertebral discs: Binding sites on vascular endothelium of the human annulus fibrosus. Acta Orthop Scand 1994; 65: 635–639.
Berse, B, JA Hunt, RJ Diegel et al. Hypoxia augments cytokine-induced vascular endothelial growth factor secretion by human synovial fibroblasts. Clin Exp Immunol 1999; 115: 176–182.
Biedert, RM, and V Sanchis-Alfonso. Sources of anterior knee pain. Clin Sports Med 2002; 21: 335–347.
Byers, PD. Solitary benign osteoblastic lesions of bone: Osteoid osteoma and benign osteoblastoma. Cancer 1968; 22: 43–57.
Calzà, L, L Giardino, A Giuliani et al. Nerve growth factor control of neuronal expression of angiogenetic and vasoactive factors. Proc Natl Acad Sci USA 2001; 98: 4160–4165.
Coppes, MH, E Marani, RT Thomeer et al. Innervation of “painful” lumbar discs. Spine 1997; 22: 2342–2349.
Dicou, E, B Pflug, M Magazin et al. Two peptides derived from the nerve growth factor precursor are biologically active. J Cell Biol 1997; 136: 389–398.
Dye, SF, GL Vaupel, and CC Dye. Conscious neurosensory mapping of the internal structures of the human knee without intra-articular anesthesia. Am J Sports Med 1998; 26: 773–777.
Dye, SF, HU Staubli, RM Biedert et al. The mosaic of pathophysiology causing patellofemoral pain: Therapeutic implications. Oper Tech Sports Med 1999; 7: 46–54.
Freemont, AJ, TE Peacock, P Goupille et al. Nerve ingrowth into diseased intervertebral disc in chronic back pain. Lancet 1997; 350: 178–181.
Fulkerson, JP. The etiology of patellofemoral pain in young active patients: A prospective study. Clin Orthop 1983; 179:129–133.
Fulkerson, JP, R Tennant, JS Jaivin et al. Histologic evidence of retinacular nerve injury associated with patellofemoral malalignment. Clin Orthop 1985; 197: 196–205.
Fulkerson, JP, and DS Hungerford. Disorders of the Patellofemoral Joint. Baltimore: Williams & Wilkins, 1990.
Gigante, A, C Bevilacqua, A Ricevuto et al. Biological aspects in patello-femoral malalignment. Eleventh Congress European Society of Sports Traumatology, Knee Surgery and Arthroscopy, Book of Abstracts, Athens, 5–8 May, 2004: 218.
Grelsamer, RP, and J McConnell. The Patella: A Team Approach. Gaithersburg, MD: Aspen, 1998.
Grönblad, M, O Korkala, YT Konttinen et al. Silver impregnation and immunohistochemical study of nerves in lumbar facet joint plical tissue. Spine 1991; 16: 34–38.
Grönblad, M, JN Weinstein, and S Santavirta. Immunohistochemical observations on spinal tissue innervation: A review of hypothetical mechanisms of back pain. Acta Orthop Scand 1991; 62: 614–622.
Hasegawa, T, T Hirose, R Sakamoto et al. Mechanism of pain in osteoid osteomas: An immunohistochemical study. Histopathology 1993; 22: 487–491.
Hayashi, T, M Sakurai, K Abe et al. Expression of angiogenic factors in rabbit spinal cord after transient ischaemia. Neuropathol Appl Neurobiol 1999; 25: 63–71.
Isaacson, LG, and KA Crutcher. The duration of sprouted cerebrovascular axons following intracranial infusion of nerve growth factor. Exp Neurol 1995; 13: 174–179.
Jackson, JR, JAL Minton, ML Ho et al. Expression of vascular endothelial growth factor in synovial fibroblasts is induced by hipoxia and interleukin 1a. J Rheumatol 1997; 24: 1253–1259.
Jerosch, J, and M Prymka. Knee joint propioception in patients with posttraumatic recurrent patella dislocation. Knee Surg, Sports Traumatol, Arthrosc 1996; 4: 14–18.
Kasim, N, and JP Fulkerson. Resection of clinically localized segments of painful retinaculum in the treatment of selected patients with anterior knee pain. Am J Sports Med 2000; 28: 811–814.
Kawaja, MD. Sympathetic and sensory innervation of the extracerebral vasculature: Roles for p75NTR neuronal expression and nerve growth factor. J Neurosci Res 1998; 52: 295–306.
Kocher, MS, FH Fu, and ChD Harner. Neuropathophysiology. In Fu, FH, ChD Harner, KG Vince, eds., Knee Surgery. Baltimore: Williams and Wilkins, 1994, pp. 231–249.
Konttinen, YT, M Grönblad, I Antti-Poika et al. Neuroimmunohistochemical analysis of peridiscal nociceptive neural elements. Spine 1990; 15: 383–386.
Korkala, O, M Grönblad, P Liesi et al. Immunohistochemical demonstration of nociceptors in the ligamentous structures of the lumbar spine. Spine 1985; 10: 156–157.
Kraushaar, BS, and RP Nirschl. Tendinosis of the elbow (tennis elbow). J Bone Joint Surg 1999; 81-A: 259–278.
Lee, TH, H Kato, K Kogure et al. Temporal profile of nerve growth factor-like immunoreactivity after transient focal cerebral ischemia in rats. Brain Res 1996; 713: 199–210.
Liu, Y, SR Cox, T Morita et al. Hypoxia regulates vascular endothelial growth factor gene expression in endothelial cells: Identification of a 5° enhancer. Circ Res 1995; 77: 638–643.
Malcangio, M, NE Garrett, S Cruwys et al. Nerve growth factor-and neurotrophin-3-induced changes in nociceptive threshold and the release of substance P from the rat isolated spinal cord. J Neurosci 1997; 17: 8459–8467.
Marti, HJ, M Bernaudin, A Bellail et al. Hypoxiainduced vascular endothelial growth factor expression precedes neovascularization after cerebral ischemia. Am J Pathol 2000; 156: 965–976.
Messner, K, Y Wei, B Andersson et al. Rat model of Achilles tendon disorder: A pilot study. Cells Tissues Organs 1999; 165: 30–39.
Minchenko, A, T Bauer, S Salceda et al. Hypoxic stimulation of vascular endothelial growth factor expression in vitro and in vivo. Lab Invest 1994; 71: 374–379.
Mori, Y, A Fujimoto, H Okumo et al. Lateral retinaculum release in adolescent patellofemoral disorders: Its relationship to peripheral nerve injury in the lateral retinaculum. Bull Hosp Jt Dis Orthop Inst 1991; 51: 218–229.
Mukai, K, J Rosai, and WH Burgdorf. Localization of factor VIII-related antigen in vascular endothelial cells using an immunoperoxidase method. Am J Surg Pathol 1980; 4: 273–276.
Nagashima, M, S Yoshino, T Ishiwata et al. Role of vascular endothelial growth factor in angiogenesis of rheumatoid arthritis. J Rheumatol 1995; 22: 1624–1630.
Nilsson, G, K Forsberg-Nilsson, Z Xiang et al. Human mast cells express functional TrkA and are a source of nerve growth factor. Eur J Immunol 1997; 27: 2295–2301.
Palmgren, T, M Grönblad, J Virri, et al. Immunohistochemical demonstration of sensory and autonomic nerve terminals in herniated lumbar disc tissue. Spine 1996; 21: 1301–1306.
Pufe, T, W Petersen, B Tillmann et al. The splice variants VEGF121 and VEGF189 of the angiogenic peptide vascular endothelial growth factor are expressed in osteoarthritic cartilage. Arthritis Rheum 2001; 44: 1082–1088.
Richard, DE, E Berra, and J Pouyssegur. Angiogenesis: How a tumor adapts to hypoxia. Biochem Biophys Res Commun 1999; 266: 718–722.
Richardson, EP, and U DeGirolami. Pathology of the Peripheral Nerve. Philadelphia: W.B. Saunders, 1995.
Sanchis-Alfonso, V, E Gastaldi-OrquÍn, and V Martinez-SanJuan. Usefulness of computed tomography in evaluating the patellofemoral joint before and after Insall’s realignment: Correlation with short-term clinical results. Am J Knee Surg 1994; 7: 65–72.
Sanchis-Alfonso, V, E Roselló-Sastre, C Monteagudo-Castro et al. Quantitative analysis of nerve changes in the lateral retinaculum in patients with isolated symptomatic patellofemoral malalignment: A preliminary study. Am J Sports Med 1998; 26: 703–709.
Sanchis-Alfonso, V, and E Roselló-Sastre. Proliferación neural e isquemia. Rev Patol Rodilla 1998; 3: 60–63.
Sanchis-Alfonso, V, E Roselló-Sastre, and A SubÍas-López. Mechanisms of pain in jumper’s knee: A histological and immunohistochemical study. J Bone Joint Surg 1999; 81-B(SUPP I): 82.
Sanchis-Alfonso, V, E Roselló-Sastre, and V Martinez-SanJuan. Pathogenesis of anterior knee pain syndrome and functional patellofemoral instability in the active young: A review. Am J Knee Surg 1999; 12: 29–40.
Sanchis-Alfonso, V, and E Roselló-Sastre. Immunohistochemical analysis for neural markers of the lateral retinaculum in patients with isolated symptomatic patellofemoral malalignment: A neuroanatomic basis for anterior knee pain in the active young patient. Am J Sports Med 2000; 28: 725–731.
Sanchis-Alfonso, V, E Roselló-Sastre, and F Revert. Neural growth factor expression in the lateral retinaculum in painful patellofemoral malalignment. Acta Orthop Scand 2001; 72: 146–149.
Sanchis-Alfonso, V, E Roselló-Sastre, and A SubÍas-López. Neuroanatomic basis for pain in patellar tendinosis (“jumper’s knee”): A neuroimmunohistochemical study. Am J Knee Surg 2001; 14: 174–177.
Sanchis-Alfonso, V, and E Roselló-Sastre. Anterior knee pain in the young patient: What causes the pain? “Neural model.” Acta Orthop Scand 2003; 74: 697–703.
Sanchis-Alfonso, V, E Roselló-Sastre, F Revert, et al. Histologic retinacular changes associated with ischemia in painful patellofemoral malalignment. Orthopedics (in press).
Sherman, BE, and RA Chole. A mechanism for sympathectomy-induced bone resorption in the middle ear. Otolaryngol Head Neck Surg 1995; 113: 569–581.
Shweiki, D, A Itin, D Soffer et al. Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature 1992; 359: 843–845.
Society for Ultrastructural Pathology. Handbook of Diagnostic Electron Microscopy for Pathologists-in-Training. New York-Tokyo: Igaku-Shoin Medical Publishers Committee, 1995.
Soifer, TB, HJ Levy, FM Soifer et al. Neurohistology of the subacromial space. Arthroscopy 1996; 12: 182–186.
Solomonow, M, and R D’Ambrosia. Neural reflex arcs and muscle control of knee stability and motion. In Scott, WN, ed., Ligament and Extensor Mechanism Injuries of the Knee: Diagnosis and Treatment. St. Louis: Mosby-Year Book, 1991, pp. 389–400.
Steinbrech, DS, BJ Mehrara, PB Saadeh et al. Hypoxia regulates VEGF expression and cellular proliferation by osteoblasts in vitro. Plast Reconstr Surg 1999; 104: 738–747.
Wilson, AS, and HB Lee. Hypothesis relevant to defective position sense in a damaged knee. J Neurol Neurosurg Psychiatry 1986; 49: 1462–1463.
Witonski, D, and M Wagrowska-Danielewicz. Distribution of substance-P nerve fibers in the knee joint in patients with anterior knee pain syndrome. Knee Surg Sports Traumatol Arthrosc 1999; 7: 177–183.
Wojtys, EM, DN Beaman, RA Glover, and D Janda. Innervation of the human knee joint by substance-P fibers. Arthroscopy 1990; 6: 254–263.
Woolf, CJ, A Allchorne, B Safieh-Garabedian et al. Cytokines, nerve growth factor and inflammatory hyperalgesia: The contribution of tumour necrosis factor alpha. Br J Pharmacol 1997; 121: 417–424.
Yamada, T, M Sawatsubashi, H Yakushiji et al. Localization of vascular endothelial growth factor in synovial membrane mast cells: Examination with “multi-labelling subtraction immunostaining.” Virchows Arch 1998; 433: 567–570.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2006 Springer-Verlag London Limited
About this chapter
Cite this chapter
Sanchis-Alfonso, V., Roselló-Sastre, E., Saus-Mas, J., Revert-Ros, F. (2006). Neuroanatomical Bases for Anterior Knee Pain in the Young Patient: “Neural Model”. In: Sanchis-Alfonso, V. (eds) Anterior Knee Pain and Patellar Instability. Springer, London. https://doi.org/10.1007/1-84628-143-1_3
Download citation
DOI: https://doi.org/10.1007/1-84628-143-1_3
Publisher Name: Springer, London
Print ISBN: 978-1-84628-003-0
Online ISBN: 978-1-84628-143-3
eBook Packages: MedicineMedicine (R0)