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Integrin Signaling in Cancer

  • Chapter
Molecular Targeting and Signal Transduction

Part of the book series: Cancer Treatment and Research ((CTAR,volume 119))

Conclusions

This review highlights the current knowledge of the alterations that occur in cancer and that involve integrins and integrin-activated pathways. Integrins are cell surface receptors for ECM proteins that mediate a variety of functions related to cell proliferation, differentiation, and survival. Although the specific functions of integrins and their ligands in cancer need to be further investigated, recent publicationsoutlining their expression pave the way for future investigations describing integrin functional alterations and the signaling pathways involved in cancer progression. Similarly, changes in integrin affinity, avidity, or activation state are likely to control cell-ECM interaction; additional investigations on these topics will help understanding the role of integrins in cancer. Future research will focus on functional correlates, combining general knowledge of integrins and integrin signaling with an increasing appreciation for the role of the ECM in cancer progression. Integrins and their downstream signaling effectors appear to be promising targets for cancer therapy.

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  1. Departments of Cancer Biology and Cell Biology, University of Massachusetts Medical School, Boston, Massachusetts

    Hira Lal Goel & Lucia R. Languino

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  1. M. D. Anderson Cancer Center, The University of Texas, Houston, TX, USA

    Rakesh Kumar Ph.D.

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Goel, H.L., Languino, L.R. (2004). Integrin Signaling in Cancer. In: Kumar, R. (eds) Molecular Targeting and Signal Transduction. Cancer Treatment and Research, vol 119. Springer, Boston, MA. https://doi.org/10.1007/1-4020-7847-1_2

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  • DOI: https://doi.org/10.1007/1-4020-7847-1_2

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4020-7822-4

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