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Fungal ß-Glucans and their Receptors

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Immunology of Fungal Infections

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Abstract

ß-Glucans are predominant carbohydrates found in the cell wall of many fungi which possess immune-modulating activities. Recognition of these carbohydrates is thought to occur via multiple receptors and at least four different receptors have been identified, including Dectin-1, complement receptor 3, lactosylceramide, and scavenger receptors. There is growing evidence that ß-glucan recognition is an important component of anti-fungal immunity, but may also contribute to development of certain diseases. In this chapter we will review each of these aspects, highlighting the roles of ß-glucans and their receptors in fungal recognition and immunity

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  1. Institute of Infectious Disease and Molecular Medicine, CLS, University of Cape Town, Observatory, 7925, Cape Town, South Africa

    S. Vicky Tsoni & Gordon D. Brown

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  1. University of Cape Town, Cape Town, South Africa

    Gordon D. Brown

  2. Radboud University Nijmegen, Nijmegen, The Netherlands

    Mihai G. Netea

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Tsoni, S.V., Brown, G.D. (2007). Fungal ß-Glucans and their Receptors. In: Brown, G.D., Netea, M.G. (eds) Immunology of Fungal Infections. Springer, Dordrecht. https://doi.org/10.1007/1-4020-5492-0_12

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