Abstract
The Ras branch of the Ras superfamily of GTPases comprises 20 proteins that can be classified in 7 subgroups (Ras, Rap, Ral, R-Ras, Rit/Rin, Rheb, ARRHI/Di-Ras) according to sequence homology. Most of them act as molecular switches that alternate between an inactive GDP-bound and an active GTP-bound conformation, except for ARHI/Di-Ras that remain complexed to GTP. Each of these proteins may be activated by several GEFs (guanine nucleotide exchange factors) in response to various extracellular stimuli, and interacts with several downstream effectors, many of which have been characterized in great detail. Proteins of the Ras family are involved in a great array of biological functions such as the control of cellular proliferation, differentiation, integrin-dependent adhesion, cell-cell junctions, motility and intracellular trafficking. This chapter attempts to review our current understanding of the biology of the proteins, other than H-, K- and N-Ras, of the Ras family
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Gunzburg, J.D. (2006). Ras Family Proteins. In: Der, C. (eds) RAS Family GTPases. Proteins and Cell Regulation, vol 4. Springer, Dordrecht. https://doi.org/10.1007/1-4020-4708-8_13
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