Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Thompson TN. 2001. Optimization of metabolic stability as a goal of modern drug design. Med Res Rev 21:412–449.
Pickett S. 2003. The biophore concept. Methods and Principles in Medicinal Chemistry 19:73–105.
Balant LP, Gex-Fabry M, Balant-Gorgia EA. 2000. Pharmacokinetics: from genes to therapeutic drug monitoring. In: Sirtori CR, Kuhlmann J, Tillement J-P, Vrhovac B, editors. Clinical Pharmacology. London: McGraw-Hill International Ltd., pp 9–24.
Wilkinson GR. 2001. Pharmacokinetics: The Dynamics of Drug Absorption, Distribution, and Elimination. In: Hardman JG, Limbird LE, Gilman GA, editors. Goodman&Gilman’s The pharmacological Basis of Therapeutics, 10th ed. New York: McGraw-Hill International Ltd. (Medical Publishing Division), pp 3–29.
The Merck Manual — Second Home Edition. 2004. Section 2. Drugs, Chapter 11, Drug Administration and Kinetics, available at www.merckhomeedition.com/home.html.
Taylor JB, Kennewell PD. 1993. The Pharmaceutical phase. Routes of administration of medicines. In: Modern Medicinal Chemistry, New York: Ellis Horwood Ltd, pp 58–71.
Benet LZ, Perotti BYT. 1995. Drug Absorption, Distribution and Elimination. In: Woolf ME, editor. Burger’s Medicinal Chemistry and Drug Discovery, 5th ed., Vol. I: Principles and Practice. New York: John Wiley & Sons, Inc. (A Wiley-Interscience Publication), pp 113–128.
Franklin MR, Franz DN. 2000. Drug Absorption, Action, and Disposition. In: Gennaro AR, editor. Remington: The Science and Practice of Pharmacy, 20th ed. Philadelphia: Lippincott Williams&Wilkins, pp 1098–1126.
Ying J, Zhiqiang J. 2003. Advances on oral mucosal drug delivery system. Zhongguo Shenghua Yaowu Zazhi 24:150–152.
Ward PD, Tippin TK, Thakker DR. 2000. Enhancing paracellular permeability by modulating epithelial tight junctions. Pharm Sci Technol To 3: 346–358.
Lennernas H. 2003. Intestinal drug absorption and bioavailability: Beyond involvement of single transport function. J Pharm Pharmacol 55:429–433.
Agoram B, Woltosz WS, Bolger MB. 2001. Predicting the impact of physiological and biochemical processes on oral drug bioavailability. Bulletin Technique Gattefosse 94:41–65.
Levitt MD, Levitt DG. 2000. Appropriate use and misuse of blood concentration measurements to quantitate first-pass metabolism. J Lab Clin Med 136:275–280.
Kwan KC. 1997. Oral bioavailability and first-pass effects. Drug Metab Dispos 25:1329–1336.
Welling PG. 1996. Effects of food on drug absorption. Annu Rev Nutr 16:383–415.
Hiebert LM. 2002. Oral heparins. Clin Lab (Heidelberg, Germany) 48:111–116.
Miller AJ, Smith KJ. 2003. Controlled-release opioids. Pain 449–473.
The technology of the PHS (Positive Higher Structure), available at http://www.tupbyosystems.com/PHS/biotech.html.
Jeong DS, Shim CK, Lee MH, Kim SK. 1988. Manufacturing and evaluation of proliposomes. J Pharm Soc Kor 32:234–238.
Arbós P, Campanero MA, Arangoa MA, Irache JM. 2004. Nanoparticles with specific bioadhesive properties to circumvent the pre-systemic degradation of fluorinated pyrimidines. J Control Release 96:55–65.
Sinha VR, Singla AK, Wadhawan S, Kaushik R, Kumria R, Bansal K, Dhawan S. 2004. Chitosan microspheres as a potential carrier for drugs. Int J Pharm 274:1–33.
Gutiérrez Millán C, Sayalero Marinero ML, Castañeda AZ, Lanao JM. 2004. Drug, enzyme and peptide delivery using erythrocytes as carriers. J Control Release 95:27–49.
Fedorak RN, Bistritz L. 2005. Targeted delivery, safety, and efficacy of oral enteric-coated formulations of budesonide. Adv Drug Deliver Rev 57:303–316.
Ripamonti C, Bruera E. 1991. Rectal, bucal, and sublingual narcotics for the management of cancer pain. J Palliative Care 7:30–35.
Watanabe Y. 2000. A review of recent pharmaceutical preparations for rectal and vaginal administrations. Pharm Tech Japan 16:1767–1770, 1773–1776.
Casali F, Burgat V, Guerre P. 1999. Dimethyl sulfoxide (DMSO): properties and permitted uses. Rev Med Vet-Toulouse 150:207–220.
Vanbever R. 2003. Optimization of dry powder aerosols for systemic drug delivery. Optim Aerosol Drug Deliv 91–103.
Steckel H. 2003. Drug delivery systems for inhalable glucocorticoids. Pharmazie in Unserer Zeit 32:314–322.
Guofeng L, Jianhai C, Kang Z. 2003. Development of liposome for local administration and its efficacy against local inflammation. Zhongguo Yaoxue Zazhi (Beijing, China) 38:825–828.
Wilkinson GR. 2001. Pharmacokinetics: The Dynamics of Drug Absorption, Distribution, and Elimination. In: Hardman JG, Limbird LE, Gilman GA, editors. Goodman & Gilman’s The pharmacological Basis of Therapeutics, 10th ed. New York: McGraw-Hill International Ltd. (Medical Publishing Division), p 8.
Lodenberg R, Amidon GL. 2000. Modern bioavailability, bioequivalence and biopharmaceutics classification system. New scientific approaches to international regulatory standards. Eur J Pharm Biopharm 50:3–12.
Shen T, Huinan X. 2003. Development of intestinal absorption enhancers. Zhongguo Yiayao Gongye Zazhi 34:476–480.
Babu RJ, Pandit JK. 2004. Effect of cyclodextrins on the complexation and transdermal delivery of bupranolol through rat skin. Int J Pharm 271:155–165.
2002. In: Sweetman SC, editor. Martindale: The Complete Drug Reference, 33rd ed. London: Pharmaceutical Press, electronic version (prepared by the editorial staff of the Royal Pharmaceutical Society of Great Britain).
Frömming K-H, Szejtli J. 1994. Pharmacokinetics and Biopharmaceutics. In: Cyclodextrins in Pharmacy. Dordrecht: Kluwer Academic Publishers pp 105–126.
Naik A, Kalia YN. Guy RH. 2000. Transdermal drug delivery: overcoming the skin’s barrier function. Pharm Sci Technol To 3:318–326.
Kalia YN, Merino V, Guy RH. 1998. Transdermal drug delivery. Clinical aspects. Dermatol Clin 16:289–299.
Yogeshvar NK, Naik A, Garrison J, Guy RH. Iontophoretic drug delivery. 2004. Adv Drug Deliv Rev 56:619–658.
Machet L, Boucad A. 2002. Phonophoresis: efficiency, mechanisms and skin tolerance. Int J Pharm 243:1–15.
Bergelson LD. 1988, New Views on Lipid Dynamics: A Non-Equilibrium Model of Ligand-Receptor Interaction, Part I, Chapter 1, Basic Mechanisms of Medical Significance in Membrane Structure and Function. In: Benga Gh, Tager JM, editors. Biomembranes — Basic and Medical Research. Berlin: Springer-Verlag pp 1–12.
Jensen SC, Peppers MP. 1998. Biopharmaceutics and Pharmacokinetics. In: Rowland J, editor. Pharmacology and Drug Administration for Imaging Technologists. St. Louis (Missouri, USA): Mosby Inc., pp 30–38.
Winstanley P, Walley T. 1999. Basic principles. In: Simons B, editor. Churchill’s Pharmacology, A clinical core text for integrated curricula with self-assessment. Edinburgh: Horne T Publisher, pp 4–15.
Kansy M, Avdeef A, Fischer H. 2004. Advances in screening for membrane permeability: high resolution PAMPA for medicinal chemists. Drug Discov Today Technol 1:349–355.
Mälkiä A, Murtomäki L, Urtti A, Konturri K. 2004. Drug permeation in biomembranes: In vitro and in silico prediction and influence of physicochemical properties. Eur J Pharm Sci 23:13–47.
Barre J, Urien S. 2000. Distribution of drugs. In: Sirtori CR, Kuhlmann J, Tillement J-P, Vrhovac B, editors. Clinical Pharmacology. London: McGraw-Hill International Ltd. pp 37–43.
Galinsky RE, Svensson CK. 2000. Basic Pharmacokinetics. In: Gennaro AR editor. Remington: The Science and Practice of Pharmacy, 20th ed. Philadelphia: Lippincott Williams&Wilkins, pp 1027–1144.
Rang HP, Dale MM, Ritter JM. 1999. Absorption, distribution and fate of drugs. In: Pharmacology, 4th ed. Edinburgh: Churchill Livingstone, pp 57–89.
Wingard LB Jr, Brody TM, Larner J, Schwartz A. 1991. Pharmacodynamics. In: Kist K, Steinborn E, Salway J, editors. Human Pharmacology, Molecular-to-Clinical. St. Louis, Missouri: Mosby Year Book Inc., pp 42–45.
Ritter JM, Lewis LD, Mant T.GK. 1999. Mechanisms of Drug Action (Pharmacodynamics). In: Radojicic R, Goodgame F, editors. A Textbook of Clinical Pharmacology, 4th ed. Oxford University Press Inc., pp 8–16.
Ross EM, Kenakin TP. 2001. Pharmacodynamics: Mechanism of Drug Action and the Relationship Between Drug Concentration and Effect. In: Hardman JG, Limbird LE, Gilman GA, editors. Goodman&Gilman’s The pharmacological Basis of Therapeutics, 10th ed. New York: McGraw-Hill International Ltd. (Medical Publishing Division), pp 31–44.
Gibson GG, Skett P. 1994. Introduction to Drug Metabolism. London: Blackie Academic & Professional, An Imprint of Chapman & Hall, pp 1–2.
Correia MA. 2001. Drug Biotransformation. In: Katzung GB, editor. Basic & Clinical Pharmacology, 8th ed. New York: Lange Medical Books/Mc Graw Hill Medical Publishing Division, pp 51–63.
Stott WT, Waechter Jr JM, Rick DL, Mendrala AL. 2000. Absorption, distribution, metabolism and excretion of intravenously and dermally administered triethanolamine in mice. Food Chem Toxicol 38:1043–1051.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2005 Springer
About this chapter
Cite this chapter
(2005). Drug Metabolism in Context. In: Ionescu, C., Caira, M.R. (eds) Drug Metabolism. Springer, Dordrecht. https://doi.org/10.1007/1-4020-4142-X_1
Download citation
DOI: https://doi.org/10.1007/1-4020-4142-X_1
Publisher Name: Springer, Dordrecht
Print ISBN: 978-1-4020-4141-9
Online ISBN: 978-1-4020-4142-6
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)