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Drug Metabolism in Context

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Drug Metabolism

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References

  1. Thompson TN. 2001. Optimization of metabolic stability as a goal of modern drug design. Med Res Rev 21:412–449.

    Article  PubMed  CAS  Google Scholar 

  2. Pickett S. 2003. The biophore concept. Methods and Principles in Medicinal Chemistry 19:73–105.

    Article  CAS  Google Scholar 

  3. Balant LP, Gex-Fabry M, Balant-Gorgia EA. 2000. Pharmacokinetics: from genes to therapeutic drug monitoring. In: Sirtori CR, Kuhlmann J, Tillement J-P, Vrhovac B, editors. Clinical Pharmacology. London: McGraw-Hill International Ltd., pp 9–24.

    Google Scholar 

  4. Wilkinson GR. 2001. Pharmacokinetics: The Dynamics of Drug Absorption, Distribution, and Elimination. In: Hardman JG, Limbird LE, Gilman GA, editors. Goodman&Gilman’s The pharmacological Basis of Therapeutics, 10th ed. New York: McGraw-Hill International Ltd. (Medical Publishing Division), pp 3–29.

    Google Scholar 

  5. The Merck Manual — Second Home Edition. 2004. Section 2. Drugs, Chapter 11, Drug Administration and Kinetics, available at www.merckhomeedition.com/home.html.

    Google Scholar 

  6. Taylor JB, Kennewell PD. 1993. The Pharmaceutical phase. Routes of administration of medicines. In: Modern Medicinal Chemistry, New York: Ellis Horwood Ltd, pp 58–71.

    Google Scholar 

  7. Benet LZ, Perotti BYT. 1995. Drug Absorption, Distribution and Elimination. In: Woolf ME, editor. Burger’s Medicinal Chemistry and Drug Discovery, 5th ed., Vol. I: Principles and Practice. New York: John Wiley & Sons, Inc. (A Wiley-Interscience Publication), pp 113–128.

    Google Scholar 

  8. Franklin MR, Franz DN. 2000. Drug Absorption, Action, and Disposition. In: Gennaro AR, editor. Remington: The Science and Practice of Pharmacy, 20th ed. Philadelphia: Lippincott Williams&Wilkins, pp 1098–1126.

    Google Scholar 

  9. Ying J, Zhiqiang J. 2003. Advances on oral mucosal drug delivery system. Zhongguo Shenghua Yaowu Zazhi 24:150–152.

    Google Scholar 

  10. Ward PD, Tippin TK, Thakker DR. 2000. Enhancing paracellular permeability by modulating epithelial tight junctions. Pharm Sci Technol To 3: 346–358.

    Article  CAS  Google Scholar 

  11. Lennernas H. 2003. Intestinal drug absorption and bioavailability: Beyond involvement of single transport function. J Pharm Pharmacol 55:429–433.

    Article  PubMed  CAS  Google Scholar 

  12. Agoram B, Woltosz WS, Bolger MB. 2001. Predicting the impact of physiological and biochemical processes on oral drug bioavailability. Bulletin Technique Gattefosse 94:41–65.

    CAS  Google Scholar 

  13. Levitt MD, Levitt DG. 2000. Appropriate use and misuse of blood concentration measurements to quantitate first-pass metabolism. J Lab Clin Med 136:275–280.

    Article  PubMed  CAS  Google Scholar 

  14. Kwan KC. 1997. Oral bioavailability and first-pass effects. Drug Metab Dispos 25:1329–1336.

    PubMed  CAS  Google Scholar 

  15. Welling PG. 1996. Effects of food on drug absorption. Annu Rev Nutr 16:383–415.

    Article  PubMed  CAS  Google Scholar 

  16. Hiebert LM. 2002. Oral heparins. Clin Lab (Heidelberg, Germany) 48:111–116.

    CAS  Google Scholar 

  17. Miller AJ, Smith KJ. 2003. Controlled-release opioids. Pain 449–473.

    Google Scholar 

  18. The technology of the PHS (Positive Higher Structure), available at http://www.tupbyosystems.com/PHS/biotech.html.

    Google Scholar 

  19. Jeong DS, Shim CK, Lee MH, Kim SK. 1988. Manufacturing and evaluation of proliposomes. J Pharm Soc Kor 32:234–238.

    Google Scholar 

  20. Arbós P, Campanero MA, Arangoa MA, Irache JM. 2004. Nanoparticles with specific bioadhesive properties to circumvent the pre-systemic degradation of fluorinated pyrimidines. J Control Release 96:55–65.

    Article  PubMed  CAS  Google Scholar 

  21. Sinha VR, Singla AK, Wadhawan S, Kaushik R, Kumria R, Bansal K, Dhawan S. 2004. Chitosan microspheres as a potential carrier for drugs. Int J Pharm 274:1–33.

    Article  PubMed  CAS  Google Scholar 

  22. Gutiérrez Millán C, Sayalero Marinero ML, Castañeda AZ, Lanao JM. 2004. Drug, enzyme and peptide delivery using erythrocytes as carriers. J Control Release 95:27–49.

    Article  CAS  Google Scholar 

  23. Fedorak RN, Bistritz L. 2005. Targeted delivery, safety, and efficacy of oral enteric-coated formulations of budesonide. Adv Drug Deliver Rev 57:303–316.

    Article  CAS  Google Scholar 

  24. Ripamonti C, Bruera E. 1991. Rectal, bucal, and sublingual narcotics for the management of cancer pain. J Palliative Care 7:30–35.

    CAS  Google Scholar 

  25. Watanabe Y. 2000. A review of recent pharmaceutical preparations for rectal and vaginal administrations. Pharm Tech Japan 16:1767–1770, 1773–1776.

    CAS  Google Scholar 

  26. Casali F, Burgat V, Guerre P. 1999. Dimethyl sulfoxide (DMSO): properties and permitted uses. Rev Med Vet-Toulouse 150:207–220.

    CAS  Google Scholar 

  27. Vanbever R. 2003. Optimization of dry powder aerosols for systemic drug delivery. Optim Aerosol Drug Deliv 91–103.

    Google Scholar 

  28. Steckel H. 2003. Drug delivery systems for inhalable glucocorticoids. Pharmazie in Unserer Zeit 32:314–322.

    Article  PubMed  CAS  Google Scholar 

  29. Guofeng L, Jianhai C, Kang Z. 2003. Development of liposome for local administration and its efficacy against local inflammation. Zhongguo Yaoxue Zazhi (Beijing, China) 38:825–828.

    Google Scholar 

  30. Wilkinson GR. 2001. Pharmacokinetics: The Dynamics of Drug Absorption, Distribution, and Elimination. In: Hardman JG, Limbird LE, Gilman GA, editors. Goodman & Gilman’s The pharmacological Basis of Therapeutics, 10th ed. New York: McGraw-Hill International Ltd. (Medical Publishing Division), p 8.

    Google Scholar 

  31. Lodenberg R, Amidon GL. 2000. Modern bioavailability, bioequivalence and biopharmaceutics classification system. New scientific approaches to international regulatory standards. Eur J Pharm Biopharm 50:3–12.

    Article  Google Scholar 

  32. Shen T, Huinan X. 2003. Development of intestinal absorption enhancers. Zhongguo Yiayao Gongye Zazhi 34:476–480.

    CAS  Google Scholar 

  33. Babu RJ, Pandit JK. 2004. Effect of cyclodextrins on the complexation and transdermal delivery of bupranolol through rat skin. Int J Pharm 271:155–165.

    Article  PubMed  CAS  Google Scholar 

  34. 2002. In: Sweetman SC, editor. Martindale: The Complete Drug Reference, 33rd ed. London: Pharmaceutical Press, electronic version (prepared by the editorial staff of the Royal Pharmaceutical Society of Great Britain).

    Google Scholar 

  35. Frömming K-H, Szejtli J. 1994. Pharmacokinetics and Biopharmaceutics. In: Cyclodextrins in Pharmacy. Dordrecht: Kluwer Academic Publishers pp 105–126.

    Google Scholar 

  36. Naik A, Kalia YN. Guy RH. 2000. Transdermal drug delivery: overcoming the skin’s barrier function. Pharm Sci Technol To 3:318–326.

    Article  CAS  Google Scholar 

  37. Kalia YN, Merino V, Guy RH. 1998. Transdermal drug delivery. Clinical aspects. Dermatol Clin 16:289–299.

    CAS  Google Scholar 

  38. Yogeshvar NK, Naik A, Garrison J, Guy RH. Iontophoretic drug delivery. 2004. Adv Drug Deliv Rev 56:619–658.

    Article  CAS  Google Scholar 

  39. Machet L, Boucad A. 2002. Phonophoresis: efficiency, mechanisms and skin tolerance. Int J Pharm 243:1–15.

    Article  PubMed  CAS  Google Scholar 

  40. Bergelson LD. 1988, New Views on Lipid Dynamics: A Non-Equilibrium Model of Ligand-Receptor Interaction, Part I, Chapter 1, Basic Mechanisms of Medical Significance in Membrane Structure and Function. In: Benga Gh, Tager JM, editors. Biomembranes — Basic and Medical Research. Berlin: Springer-Verlag pp 1–12.

    Google Scholar 

  41. Jensen SC, Peppers MP. 1998. Biopharmaceutics and Pharmacokinetics. In: Rowland J, editor. Pharmacology and Drug Administration for Imaging Technologists. St. Louis (Missouri, USA): Mosby Inc., pp 30–38.

    Google Scholar 

  42. Winstanley P, Walley T. 1999. Basic principles. In: Simons B, editor. Churchill’s Pharmacology, A clinical core text for integrated curricula with self-assessment. Edinburgh: Horne T Publisher, pp 4–15.

    Google Scholar 

  43. Kansy M, Avdeef A, Fischer H. 2004. Advances in screening for membrane permeability: high resolution PAMPA for medicinal chemists. Drug Discov Today Technol 1:349–355.

    Article  CAS  Google Scholar 

  44. Mälkiä A, Murtomäki L, Urtti A, Konturri K. 2004. Drug permeation in biomembranes: In vitro and in silico prediction and influence of physicochemical properties. Eur J Pharm Sci 23:13–47.

    Article  PubMed  CAS  Google Scholar 

  45. Barre J, Urien S. 2000. Distribution of drugs. In: Sirtori CR, Kuhlmann J, Tillement J-P, Vrhovac B, editors. Clinical Pharmacology. London: McGraw-Hill International Ltd. pp 37–43.

    Google Scholar 

  46. Galinsky RE, Svensson CK. 2000. Basic Pharmacokinetics. In: Gennaro AR editor. Remington: The Science and Practice of Pharmacy, 20th ed. Philadelphia: Lippincott Williams&Wilkins, pp 1027–1144.

    Google Scholar 

  47. Rang HP, Dale MM, Ritter JM. 1999. Absorption, distribution and fate of drugs. In: Pharmacology, 4th ed. Edinburgh: Churchill Livingstone, pp 57–89.

    Google Scholar 

  48. Wingard LB Jr, Brody TM, Larner J, Schwartz A. 1991. Pharmacodynamics. In: Kist K, Steinborn E, Salway J, editors. Human Pharmacology, Molecular-to-Clinical. St. Louis, Missouri: Mosby Year Book Inc., pp 42–45.

    Google Scholar 

  49. Ritter JM, Lewis LD, Mant T.GK. 1999. Mechanisms of Drug Action (Pharmacodynamics). In: Radojicic R, Goodgame F, editors. A Textbook of Clinical Pharmacology, 4th ed. Oxford University Press Inc., pp 8–16.

    Google Scholar 

  50. Ross EM, Kenakin TP. 2001. Pharmacodynamics: Mechanism of Drug Action and the Relationship Between Drug Concentration and Effect. In: Hardman JG, Limbird LE, Gilman GA, editors. Goodman&Gilman’s The pharmacological Basis of Therapeutics, 10th ed. New York: McGraw-Hill International Ltd. (Medical Publishing Division), pp 31–44.

    Google Scholar 

  51. Gibson GG, Skett P. 1994. Introduction to Drug Metabolism. London: Blackie Academic & Professional, An Imprint of Chapman & Hall, pp 1–2.

    Google Scholar 

  52. Correia MA. 2001. Drug Biotransformation. In: Katzung GB, editor. Basic & Clinical Pharmacology, 8th ed. New York: Lange Medical Books/Mc Graw Hill Medical Publishing Division, pp 51–63.

    Google Scholar 

  53. Stott WT, Waechter Jr JM, Rick DL, Mendrala AL. 2000. Absorption, distribution, metabolism and excretion of intravenously and dermally administered triethanolamine in mice. Food Chem Toxicol 38:1043–1051.

    Article  PubMed  CAS  Google Scholar 

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(2005). Drug Metabolism in Context. In: Ionescu, C., Caira, M.R. (eds) Drug Metabolism. Springer, Dordrecht. https://doi.org/10.1007/1-4020-4142-X_1

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