Abstract
Theoretical work on adaptation has lagged behind experimental. But two classes of adaptation model have been partly explored. One is phenotypic and the other DNA sequence based. I briefly consider an example of each — Fisher’s geometric model and Gillespie’s mutational landscape model, respectively — reviewing recent results. Despite their fundamental differences, these models give rise to several strikingly similar results. I consider possible reasons for this congruence. I also emphasize what predictions do and, as important, do not follow from these models.
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References
Barton, N., 1998. The geometry of natural selection. Nature 395: 751–752.
Barton, N.H., 2001. The role of hybridization in evolution. Mol. Ecol. 10: 551–568.
Barton, N.H. & P.D. Keightley, 2002. Understanding quantitative genetic variation. Nature Rev. Genet. 3: 11–21.
Bradshaw, H.D., K.G. Otto, B.E. Frewen, J.K. McKay & D.W. Schemske, 1998. Quantitative trait loci affecting differences in floral morphology between two species of Monkeyflower (Mimulus). Genetics 149: 367–382.
Bull, J.J., M.R. Badgett, H.A. Wichman, J.P. Huelsenbeck, D.M. Hillis, A. Gulati, C. Ho & I.J. Molineux, 1997. Exceptional convergent evolution in a virus. Genetics 147: 1497–1507.
Fisher, R.A., 1930. The Genetical Theory of Natural Selection. Oxford University Press, Oxford.
Fisher, R.A., 2000. The Genetical Theory of Natural Selection: a Complete Variorum Edition. Oxford University Press, Oxford.
Gerrish, P., 2001. The rhythm of microbial adaptation. Nature 413: 299–302.
Gerrish, P.J. & R.E. Lenski, 1998. The fate of competing beneficial mutations in an asexual population. Genetica 102/103: 127–144.
Gillespie, J., 1984. Molecular evolution over the mutational landscape. Evolution 38: 1116–1129.
Gillespie, J.H., 1991. The Causes of Molecular Evolution. Oxford University Press, Oxford.
Gillespie, J.H., 2002. Why k = 4Nus is silly in Evolutionary Genetics, edited by R.S. Singh. Vol. III.
Gumbel, E.J., 1958. Statistics of Extremes. Columbia University Press, New York.
Hartl, D. & C.H. Taubes, 1998. Compensatory nearly neutral mutations: selection without adaptation. J. Theor. Biol. 182: 303–309.
Kauffman, S.A., 1993. The Origins of Order. Oxford University Press, New York.
Kimura, M., 1983. The Neutral Theory of Molecular Evolution. Cambridge University Press, Cambridge, UK.
Leadbetter, M.R., G. Lindgren & H. Rootzen, 1980. Extremes and Related Properties of Random Sequences and Processes. Springer-Verlag, New York.
Long, A.D., R.F. Lyman, A.H. Morgan, C.H. Langley & T.F. Mackay, 2000. Both naturally occurring insertions of transposable elements and intermediate frequency polymorphisms at the achaete-scute complex are associated with variation in bristle number in Drosophila melanogaster. Genetics 154: 1255–1269.
Maynard Smith, J., 1962. The limitations of molecular evolution, pp. 252–256 in The Scientist Speculates: an Anthology of Partly-baked Ideas, edited by I.J. Good. Basic Books, Inc., New York.
Maynard Smith, J., 1970. Natural selection and the concept of a protein space. Nature 225: 563–564.
Orr, H.A., 1998a. The population genetics of adaptation: the distribution of factors fixed during adaptive evolution. Evolution 52: 935–949.
Orr, H.A., 1998b. Testing natural selection versus genetic drift in phenotypic evolution using quantitative trait locus data. Genetics 149: 2099–2104.
Orr, H.A., 1999. The evolutionary genetics of adaptation: a simulation study. Genet. Res. 74: 207–214.
Orr, H.A., 2000. Adaptation and the cost of complexity. Evolution 54: 13–20.
Orr, H.A., 2001. The ‘sizes’ of mutations fixed in phenotypic evolution: a response to Clarke and Arthur. Evol. Dev. 3: 121 123.
Orr, H.A., 2002. The population genetics of adaptation: the adaptation of DNA sequences. Evolution 56: 1317–1330.
Orr, H.A., 2003a. The distribution of fitness effects among beneficial mutations. Genetics 163: 1519–1526.
Orr, H.A., 2003b. A minimum on the mean number of steps taken in adaptive walks. J. Theor. Biol. 220: 241–247.
Poon, A. & S.P. Otto, 2000. Compensating for our load of mutations: freezing the meltdown of small populations. Evolution 54: 1467–1479.
Smith, N.G.C. & A. Eyre-Walker, 2002. Adaptive protein evolution in Drosophila. Nature 415: 1022–1024.
Welch, J.J. & D. Waxman, 2003. Modularity and the cost of complexity. Evolution 57: 1723–1734.
Wichman, H.A., M.R. Badgett, L.A. Scott, C.M. Boulianne & J.J. Bull, 1999. Different trajectories of parallel evolution during viral adaptation. Science 285: 422–424.
Zeng, Z.-B., J. Liu, L.F. Stam, C.-H. Kao, J.M. Mercer & C.C. Laurie, 2000. Genetic architecture of a morphological shape difference between two Drosophila species. Genetics 154: 299–310.
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Orr, H.A. (2005). Theories of adaptation: what they do and don’t say. In: Mauricio, R. (eds) Genetics of Adaptation. Georgia Genetics Review III, vol 3. Springer, Dordrecht. https://doi.org/10.1007/1-4020-3836-4_2
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DOI: https://doi.org/10.1007/1-4020-3836-4_2
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