Conclusions
A highly regulated network of protein-protein interactions is now known to be the central underlying theme in controlling apoptosis. Understanding the chemical basis of these interactions is a major key to understanding the mechanisms of this diverse pathway, while controlling the outcome of these interactions offers remarkable benefits to the treatment of many pathological diseases. It is now undisputed that the Bcl-2 proteins regulate the mitochondrial apoptotic pathway, however considerable controversy exists as to how they do this at the molecular level. If the desire is to regulate apotosis in various pathological conditions or even exploit the apoptosis pathway to our advantage we need to firstly understand the precise function of all of the pro- and anti-apoptotic proteins. It is vital that we determine which proteins are important in which cell lines and by which pathways they act to carry out their function before we can target them. However, it is clear that the Bcl-2 family still offers a major target for the control of apoptosis as it has been shown to be the central point of control for a variety of cellular damage signals in a multitude of cell types.
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Petch, A., Al-Rubeai, M. (2004). The Bcl-2 Family. In: Al-Rubeai, M., Fussenegger, M. (eds) Cell Engineering. Cell Engineering, vol 4. Springer, Dordrecht. https://doi.org/10.1007/1-4020-2217-4_2
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