Skip to main content
SpringerLink
Log in

PARP and the Release of Apoptosis-Inducing Factor from Mitochondria

  • Chapter
Poly(ADP-Ribosyl)ation

Part of the book series: Molecular Biology Intelligence Unit ((MBIU))

Summary

Mitochondria and the nucleus play critical roles in cell death. The signaling between these two organelles is dynamic. Understanding the signaling process between the nucleus and the mitochondria in cell death programs could lead us to more options in the development of new therapeutic targets. We discussed in this chapter how AIF could be released from the mitochondria and how AIF could act in PARP-dependent cell death mechanism. The molecular mechanisms accounting for PARP-dependent cell death are still being investigated but mitochondrial release of AIF and its translocation to the nucleus appears to be essential in this death process. We speculate that the PARP-mediated depletion of NAD and ATP or novel signals from PARP over activation might trigger AIF translocation; however, the authentic factors and the legitimate mechanism of mitochondrial AIF release remain to be explored.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Walker NI, Harmon BV, Gobe GC et al. Patterns of cell death. Methods Achiev Exp Pathol 1988; 13:18–54.

    PubMed  CAS  Google Scholar 

  2. Kerr JF, Wyllie AH, Currie AR. Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 1972; 26(4):239–57.

    PubMed  CAS  Google Scholar 

  3. Ravichandran KS. “Recruitment signals” from apoptotic cells: Invitation to a quiet meal. Cell 2003; 113(7):817–20.

    Article  PubMed  CAS  Google Scholar 

  4. Eliasson MJ, Sampei K, Mandir AS et al. Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia. Nat Med 1997; 3(10):1089–95.

    Article  PubMed  CAS  Google Scholar 

  5. Endres M, Wang ZQ, Namura S et al. Ischemic brain injury is mediated by the activation of poly(ADP-ribose)polymerase. J Cereb Blood Flow Metab 1997; 17(11):1143–51.

    Article  PubMed  CAS  Google Scholar 

  6. Zhang J, Dawson VL, Dawson TM et al. Nitric oxide activation of poly(ADP-ribose) synthetase in neurotoxicity. Science 1994; 263(5147):687–9.

    Article  PubMed  CAS  Google Scholar 

  7. Finkel T, Holbrook NJ. Oxidants, oxidative stress and the biology of ageing. Nature 2000; 408(6809):239–47.

    Article  PubMed  CAS  Google Scholar 

  8. Chan PH. Reactive oxygen radicals in signaling and damage in the ischemic brain. J Cereb Blood Flow Metab 2001; 21(1):2–14.

    Article  PubMed  CAS  Google Scholar 

  9. Ischiropoulos H, Beckman JS. Oxidative stress and nitration in neurodegeneration: Cause, effect, or association? J Clin Invest 2003; 111(2):163–9.

    Article  PubMed  CAS  Google Scholar 

  10. Wood RD, Mitchell M, Sgouros J et al. Human DNA repair genes. Science 2001; 291(5507):1284–9.

    Article  PubMed  CAS  Google Scholar 

  11. Bernstein C, Bernstein H, Payne CM et al. DNA repair/pro-apoptotic dual-role proteins in five major DNA repair pathways: Fail-safe protection against carcinogenesis. Mutat Res 2002; 511(2):145–78.

    Article  PubMed  CAS  Google Scholar 

  12. Bouchard VJ, Rouleau M, Poirier GG. PARP-1, a determinant of cell survival in response to DNA damage. Exp Hematol 2003; 31(6):446–54.

    Article  PubMed  CAS  Google Scholar 

  13. Virag L, Szabo C. The therapeutic potential of poly(ADP-Ribose) polymerase inhibitors. Pharmacol Rev 2002; 54(3):375–429.

    Article  PubMed  CAS  Google Scholar 

  14. Chiarugi A. Poly(ADP-ribose) polymerase: Killer or conspirator? The’ suicide hypothesis’ revisited. Trends Pharmacol Sci 2002; 23(3):122–9.

    Article  PubMed  CAS  Google Scholar 

  15. Gagne JP, Hunter JM, Labrecque B et al. A proteomic approach to the identification of heterogeneous nuclear ribonucleoproteins as a new family of poly(ADP-ribose)-binding proteins. Biochem J 2003; 371 (Pt 2):331–40.

    Article  PubMed  CAS  Google Scholar 

  16. Wang H, Shimoji M, Yu SW et al. Apoptosis inducing factor and PARP mediated injury in the MPTP mouse model of Parkinson’s disease: Ann N Y Acad Sci 2003; 991:132–9.

    Article  CAS  Google Scholar 

  17. Kaminker PG, Kim SH, Taylor RD et al. TANK2, a new TRF1-associated poly(ADP-ribose) polymerase, causes rapid induction of cell death upon overexpression. J Biol Chem 2001; 276(38):35891–9.

    Article  PubMed  CAS  Google Scholar 

  18. Yu SW, Wang H, Poitras MF et al. Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor. Science 2002; 297(5579):259–63.

    Article  PubMed  CAS  Google Scholar 

  19. Davidovic L, Vodenicharov M, Affar EB et al. Importance of poly(ADP-ribose) glycohydrolase in the control of poly(ADP-ribose) metabolism. Exp Cell Res 2001; 268(1):7–13.

    Article  PubMed  CAS  Google Scholar 

  20. Lin W, Ame JC, Aboul-Ela N et al. Isolation and characterization of the cDNA encoding bovine poly(ADP-ribose) glycohydrolase. J Biol Chem 1997; 272(18):11895–901.

    Article  PubMed  CAS  Google Scholar 

  21. Shimokawa T, Masutani M, Nagasawa S et al. Isolation and cloning of rat poly(ADP-ribose) glycohydrolase: Presence of a potential nuclear export signal conserved in mammalian orthologs. J Biochem (Tokyo) 1999; 126(4):748–55.

    CAS  Google Scholar 

  22. Ame JC, Apiou F, Jacobson EL et al. Assignment of the poly(ADP-ribose) glycohydrolase gene (PARG) to human chromosome 10q11.23 and mouse chromosome 14B by in situ hybridization. Cytogenet Cell Genet 1999; 85(3–4):269–70.

    PubMed  CAS  Google Scholar 

  23. Ame JC, Jacobson EL, Jacobson MK. Molecular heterogeneity and regulation of poly(ADP-ribose) glycohydrolase. Mol Cell Biochem 1999; 193(1–2):75–81.

    Article  PubMed  CAS  Google Scholar 

  24. Ying W, Swanson RA. The poly(ADP-ribose) glycohydrolase inhibitor gallotannin blocks oxidative astrocyte death. Neuroreport 2000; 11(7):1385–8.

    Article  PubMed  CAS  Google Scholar 

  25. Perkins E, Sun D, Nguyen A et al. Novel inhibitors of poly(ADP-ribose) polymerase/PARP1 and PARP2 identified using a cell-based screen in yeast. Cancer Res 2001; 61(10):4175–83.

    PubMed  CAS  Google Scholar 

  26. Jonsson GG, Jacobson EL, Jacobson MK. Mechanism of alteration of poly(adenosine diphosphate-ribose) metabolism by hyperthermia. Cancer Res 1988; 48(15):4233–9.

    PubMed  CAS  Google Scholar 

  27. Hanai S, Kanai M, Ohashi S et al. Loss of poly(ADP-ribose) glycohydrolase causes progressive neurodegeneration in Drosophila melanogaster. Proc Natl Acad Sci USA 2004; 101(1):82–6.

    Article  PubMed  CAS  Google Scholar 

  28. Susin SA, Lorenzo HK, Zamzami N et al. Molecular characterization of mitochondrial apoptosis-inducing factor. Nature 1999; 397(6718):441–6.

    Article  PubMed  CAS  Google Scholar 

  29. Ye H, Cande C, Stephanou NC et al. DNA binding is required for the apoptogenic action of apoptosis inducing factor. Nat Struct Biol 2002; 9(9):680–4.

    Article  PubMed  CAS  Google Scholar 

  30. Li LY, Luo X, Wang X. Endonuclease G is an apoptotic DNase when released from mitochondria. Nature 2001; 412(6842):95–9.

    Article  PubMed  CAS  Google Scholar 

  31. Widlak P, Li LY, Wang X et al. Action of recombinant human apoptotic endonuclease G on naked DNA and chromatin substrates: Cooperation with exonuclease and DNase I. J Biol Chem 2001; 276(51):48404–9.

    PubMed  CAS  Google Scholar 

  32. Lorenzo HK, Susin SA, Penninger J et al. Apoptosis inducing factor (AIF): A phylogenetically old, caspase-independent effector of cell death. Cell Death Differ 1999; 6(6):516–24.

    Article  PubMed  CAS  Google Scholar 

  33. Mate MJ, Ortiz-Lombardia M, Boitel B et al. The crystal structure of the mouse apoptosis-inducing factor AIF. Nat Struct Biol 2002; 9(6):442–6.

    Article  PubMed  CAS  Google Scholar 

  34. Susin SA, Lorenzo HK, Zamzami N et al. Molecular characterization of mitochondrial apoptosis-inducing factor. Nature 1999; 397(6718):441–6.

    Article  PubMed  CAS  Google Scholar 

  35. Daugas E, Susin SA, Zamzami N et al. Mitochondrio-nuclear translocation of AIF in apoptosis and necrosis. FASEB J 2000; 14(5):729–39.

    PubMed  CAS  Google Scholar 

  36. Lipton SA, Bossy-Wetzel E. Dueling activities of AIF in cell death versus survival: DNA binding and redox activity. Cell 2002; 111(2):147–50.

    Article  PubMed  CAS  Google Scholar 

  37. Klein JA, Longo-Guess CM, Rossmann MP et al. The harlequin mouse mutation downregulates apoptosis-inducing factor. Nature 2002; 419(6905):367–74.

    Article  PubMed  CAS  Google Scholar 

  38. Mate MJ, Ortiz-Lombardia M, Boitel B et al. The crystal structure of the mouse apoptosis-inducing factor AIF. Nat Struct Biol 2002; 9(6):442–6.

    Article  PubMed  CAS  Google Scholar 

  39. Joza N, Susin SA, Daugas E et al. Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death. Nature 2001; 410(6828):549–54.

    Article  PubMed  CAS  Google Scholar 

  40. Cregan SP, Fortin A, MacLaurin JG et al. Apoptosis-inducing factor is involved in the regulation of caspase-independent neuronal cell death. J Cell Biol 2002; 158(3):507–17.

    Article  PubMed  CAS  Google Scholar 

  41. Susin SA, Daugas E, Ravagnan L et al. Two distinct pathways leading to nuclear apoptosis. J Exp Med 2000; 192(4):571–80.

    Article  PubMed  CAS  Google Scholar 

  42. Loeffler M, Daugas E, Susin SA et al. Dominant cell death induction by extramitochondrially targeted apoptosis-inducing factor. FASEB J 2001; 15(3):758–67.

    Article  PubMed  CAS  Google Scholar 

  43. Lassus P, Opitz-Araya X, Lazebnik Y. Requirement for caspase-2 in stress-induced apoptosis before mitochondrial permeabilization. Science 2002; 297(5585):1352–4.

    Article  PubMed  CAS  Google Scholar 

  44. Robertson JD, Enoksson M, Suomela M et al. Caspase-2 acts upstream of mitochondria to promote cytochrome c release during etoposide-induced apoptosis. J Biol Chem 2002; 277(33):29803–9.

    Article  PubMed  CAS  Google Scholar 

  45. Zamzami N, El Hamel C, Maisse C et al. Bid acts on the permeability transition pore complex to induce apoptosis. Oncogene 2000; 19(54):6342–50.

    Article  PubMed  CAS  Google Scholar 

  46. Arnoult D, Gaume B, Karbowski M et al. Mitochondrial release of AIF and EndoG requires caspase activation downstream of Bax/Bak-mediated permeabilization. EMBO J 2003; 22(17):4385–4399.

    Article  PubMed  CAS  Google Scholar 

  47. Arnoult D, Parone P, Martinou JC et al. Mitochondrial release of apoptosis-inducing factor occurs downstream of cytochrome c release in response to several proapoptotic stimuli. J Cell Biol 2002; 159(6):923–9.

    Article  PubMed  CAS  Google Scholar 

  48. Wang X, Yang C, Chai J et al. Mechanisms of AIF-mediated apoptotic DNA degradation in Caenorhabditis elegans. Science 2002; 298(5598):1587–92.

    Article  PubMed  CAS  Google Scholar 

  49. Hisatomi T, Sakamoto T, Goto Y et al. Critical role of photoreceptor apoptosis in functional damage after retinal detachment. Curr Eye Res 2002; 24(3):161–72.

    Article  PubMed  Google Scholar 

  50. Zhang X, Chen J, Graham SH et al. Intranuclear localization of apoptosis-inducing factor (AIF) and large scale DNA fragmentation after traumatic brain injury in rats and in neuronal cultures exposed to peroxynitrite. J Neurochem 2002; 82(1):181–91.

    Article  PubMed  CAS  Google Scholar 

  51. Zhu C, Qiu L, Wang X et al. Involvement of apoptosis-inducing factor in neuronal death after hypoxia-ischemia in the neonatal rat brain. J Neurochem 2003; 86(2):306–17.

    Article  PubMed  CAS  Google Scholar 

  52. Braun JS, Novak R, Murray PJ et al. Apoptosis-inducing factor mediates microglial and neuronal apoptosis caused by pneumococcus. J Infect Dis 2001; 184(10):1300–9.

    Article  PubMed  CAS  Google Scholar 

  53. Wang X, Zhu S, Drozda M et al. Minocycline inhibits caspase-independent and-dependent mitochondrial cell death pathways in models of Huntington’s disease. Proc Natl Acad Sci USA 2003.

    Google Scholar 

  54. Ravagnan L, Gurbuxani S, Susin SA et al. Heat-shock protein 70 antagonizes apoptosis-inducing factor. Nat Cell Biol 2001; 3(9):839–43.

    Article  PubMed  CAS  Google Scholar 

  55. Ruchalski K, Mao H, Singh SK et al. HSP72 inhibits apoptosis-inducing factor release in ATP depleted renal epithelial cells. Am J Physiol Cell Physiol 2003.

    Google Scholar 

  56. Ly JD, Grubb DR, Lawen A. The mitochondrial membrane potential (deltapsi(m)) in apoptosis; an update. Apoptosis 2003; 8(2):115–28.

    Article  PubMed  CAS  Google Scholar 

  57. Newmeyer DD, Ferguson-Miller S. Mitochondria: Releasing power for life and unleashing the machineries of death. Cell 2003; 112(4):481–90.

    Article  PubMed  CAS  Google Scholar 

  58. Loeffler M, Kroemer G. The mitochondrion in cell death control: Certainties and incognita. Exp Cell Res 2000; 256(1):19–26.

    Article  PubMed  CAS  Google Scholar 

  59. van Gurp M, Festjens N, van Loo G et al. Mitochondrial intermembrane proteins in cell death. Biochem Biophys Res Commun 2003; 304(3):487–97.

    Article  PubMed  CAS  Google Scholar 

  60. Cheng EH, Sheiko TV, Fisher JK et al. VDAC2 inhibits BAK activation and mitochondrial apoptosis. Science 2003; 301(5632):513–7.

    Article  PubMed  CAS  Google Scholar 

  61. Karbowski M, Lee YJ, Gaume B et al. Spatial and temporal association of Bax with mitochondrial fission sites, Drp1, and Mfn2 during apoptosis. J Cell Biol 2002; 159(6):931–8.

    Article  PubMed  CAS  Google Scholar 

  62. Zamzami N, Kroemer G. The mitochondrion in apoptosis: How Pandora’s box opens. Nat Rev Mol Cell Biol 2001; 2(1):67–71.

    Article  PubMed  CAS  Google Scholar 

  63. D’Amours D, Desnoyers S, D’Silva I et al. Poly(ADP-ribosyl)ation reactions in the regulation of nuclear functions. Biochem J 1999; 342 (Pt 2):249–68.

    Article  PubMed  CAS  Google Scholar 

  64. Pleschke JM, Kleczkowska HE, Strohm M et al. Poly(ADP-ribose) binds to specific domains in DNA damage checkpoint proteins. J Biol Chem 2000; 275(52):40974–80.

    Article  PubMed  CAS  Google Scholar 

  65. Vaziri H, West MD, Allsopp RC et al. ATM-dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post-translational activation of p53 protein involving poly(ADP-ribose) polymerase. EMBO J 1997; 16(19):6018–33.

    Article  PubMed  CAS  Google Scholar 

  66. Fan Z, Beresford PJ, Oh DY et al. Tumor suppressor NM23-H1 is a granzyme A-activated DNase during CTL-mediated apoptosis, and the nucleosome assembly protein SET is its inhibitor. Cell 2003; 112(5):659–72.

    Article  PubMed  CAS  Google Scholar 

  67. Mabley JG, Suarez-Pinzon WL, Hasko G et al. Inhibition of poly (ADP-ribose) synthetase by gene disruption or inhibition with 5-iodo-6-amino-1,2-benzopyrone protects mice from multiple-low-dose-streptozotocin-induced diabetes. Br J Pharmacol 2001; 133(6):909–19.

    Article  PubMed  CAS  Google Scholar 

  68. Suarez-Pinzon WL, Mabley JG, Power R et al. Poly (ADP-ribose) polymerase inhibition prevents spontaneous and recurrent autoimmune diabetes in NOD mice by inducing apoptosis of islet-infiltrating leukocytes. Diabetes 2003; 52(7):1683–8.

    Article  PubMed  CAS  Google Scholar 

  69. Pacher P, Liaudet L, Soriano FG et al. The role of poly(ADP-ribose) polymerase activation in the development of myocardial and endothelial dysfunction in diabetes. Diabetes 2002; 51(2):514–21.

    Article  PubMed  CAS  Google Scholar 

  70. Mandir AS, Poitras MF, Berliner AR et al. NMDA but not nonNMDA excitotoxicity is mediated by Poly(ADP-ribose) polymerase. J Neurosci 2000; 20(21):8005–11.

    PubMed  CAS  Google Scholar 

  71. Cosi C, Colpaert F, Koek W et al. Poly(ADP-ribose) polymerase inhibitors protect against MPTP-induced depletions of striatal dopamine and cortical noradrenaline in C57B1/6 mice. Brain Res 1996b; 729(2):264–9.

    PubMed  CAS  Google Scholar 

  72. Cosi C, Chopin P, Marien M. Benzamide, an inhibitor of poly(ADP-ribose) polymerase, attenuates methamphetamine-induced dopamine neurotoxicity in the C57B1/6N mouse. Brain Res 1996a; 735(2):343–8.

    Article  PubMed  CAS  Google Scholar 

  73. Mandir AS, Przedborski S, Jackson-Lewis V et al. Poly(ADP-ribose) polymerase activation mediates 1-methyl-4-phenyl-1, 2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism. Proc Natl Acad Sci USA 1999; 96(10):5774–9.

    Article  PubMed  CAS  Google Scholar 

  74. Wang H, Shimoji M, Yu SW et al. Apoptosis inducing factor and PARP-mediated injury in the MPTP mouse model of Parkinson’s disease. Ann N Y Acad Sci 2003; 991:132–9.

    Article  PubMed  CAS  Google Scholar 

  75. Cao G, Clark RS, Pei W et al. Translocation of apoptosis-inducing factor in vulnerable neurons after transient cerebral ischemia and in neuronal cultures after oxygen-glucose deprivation. J Cereb Blood Flow Metab 2003; 23(10):1137–50.

    Article  PubMed  CAS  Google Scholar 

  76. LaPlaca MC, Zhang J, Raghupathi R et al. Pharmacologic inhibition of poly(ADP-ribose) polymerase is neuroprotective following traumatic brain injury in rats. J Neurotrauma 2001; 18(4):369–76.

    Article  PubMed  CAS  Google Scholar 

  77. Suh SW, Aoyama K, Chen Y et al. Hypoglycemic neuronal death and cognitive impairment are prevented by poly(ADP-ribose) polymerase inhibitors administered after hypoglycemia. J Neurosci 2003; 23(33):10681–90.

    PubMed  CAS  Google Scholar 

  78. Scott GS, Jakeman LB, Stokes BT et al. Peroxynitrite production and activation of poly (adenosine diphosphate-ribose) synthetase in spinal cord injury. Ann Neurol 1999; 45(1):120–4.

    Article  PubMed  CAS  Google Scholar 

  79. Cookson MR, Ince PG, Shaw PJ. Peroxynitrite and hydrogen peroxide induced cell death in the NSC34 neuroblastoma x spinal cord cell line: Role of poly (ADP-ribose) polymerase. J Neurochem 1998; 70(2):501–8.

    Article  PubMed  CAS  Google Scholar 

  80. Imai H, Koumura T, Nakajima R et al. Protection from inactivation of the adenine nucleotide translocator during hypoglycaemia-induced apoptosis by mitochondrial phospholipid hydroperoxide glutathione peroxidase. Biochem J 2003; 371(Pt 3):799–809.

    Article  PubMed  CAS  Google Scholar 

  81. Chiang SK, Lam TT. Post-treatment at 12 or 18 hours with 3-aminobenzamide ameliorates retinal ischemia-reperfusion damage. Invest Ophthalmol Vis Sci 2000; 41(10):3210–4.

    PubMed  CAS  Google Scholar 

  82. Tabuchi K, Ito Z, Tsuji S et al. Poly(adenosine diphosphate-ribose) synthetase inhibitor 3-aminobenzamide alleviates cochlear dysfunction induced by transient ischemia. Ann Otol Rhinol Laryngol 2001; 110(2):118–21.

    PubMed  CAS  Google Scholar 

  83. Jijon HB, Churchill T, Malfair D et al. Inhibition of poly(ADP-ribose) polymerase attenuates inflammation in a model of chronic colitis. Am J Physiol Gastrointest Liver Physiol 2000; 279(3):G641–51.

    PubMed  CAS  Google Scholar 

  84. Zingarelli B, O’Connor M, Hake PW. Inhibitors of poly (ADP-ribose) polymerase modulate signal transduction pathways in colitis. Eur J Pharmacol 2003; 469(1–3):183–94.

    Article  PubMed  CAS  Google Scholar 

  85. Koedel U, Winkler F, Angele B et al. Meningitis-associated central nervous system complications are mediated by the activation of poly(ADP-ribose) polymerase. J Cereb Blood Flow Metab 2002; 22(1):39–49.

    Article  PubMed  CAS  Google Scholar 

  86. Braun JS, Sublett JE, Freyer D et al. Pneumococcal pneumolysin and H(2)O(2) mediate brain cell apoptosis during meningitis. J Clin Invest 2002; 109(1):19–27.

    Article  PubMed  CAS  Google Scholar 

  87. Miesel R, Kurpisz M, Kroger H. Modulation of inflammatory arthritis by inhibition of poly(ADP ribose) polymerase. Inflammation 1995; 19(3):379–87.

    Article  PubMed  CAS  Google Scholar 

  88. Rice WG, Schaeffer CA, Harten B et al. Inhibition of HIV-1 infectivity by zinc-ejecting aromatic C-nitroso compounds. Nature 1993; 361(6411):473–5.

    Article  PubMed  CAS  Google Scholar 

  89. Ferri KF, Jacotot E, Blanco J et al. Apoptosis control in syncytia induced by the HIV type 1-envelope glycoprotein complex: Role of mitochondria and caspases. J Exp Med 2000; 192(8):1081–92.

    Article  PubMed  CAS  Google Scholar 

  90. Genini D, Sheeter D, Rought S et al. HIV induces lymphocyte apoptosis by a p53-initiated, mitochondrial-mediated mechanism. FASEB J 2001; 15(1):5–6.

    PubMed  CAS  Google Scholar 

  91. Ha HC, Juluri K, Zhou Y et al. Poly(ADP-ribose) polymerase-1 is required for efficient HIV-1 integration. Proc Natl Acad Sci USA 2001; 98(6):3364–8.

    Article  PubMed  CAS  Google Scholar 

  92. Oliver FJ, Menissier-de Murcia J, Nacci C et al. Resistance to endotoxic shock as a consequence of defective NF-kappaB activation in poly (ADP-ribose) polymerase-1 deficient mice. EMBO J 1999; 18(16):4446–54.

    Article  PubMed  CAS  Google Scholar 

  93. Veres B, Gallyas Jr F, Varbiro G et al. Decrease of the inflammatory response and induction of the Akt/protein kinase B pathway by poly-(ADP-ribose) polymerase 1 inhibitor in endotoxin-induced septic shock. Biochem Pharmacol 2003; 65(8):1373–82.

    Article  PubMed  CAS  Google Scholar 

  94. Broaddus VC, Yang L, Scavo LM et al. Asbestos induces apoptosis of human and rabbit pleural mesothelial cells via reactive oxygen species. J Clin Invest 1996; 98(9):2050–9.

    Article  PubMed  CAS  Google Scholar 

  95. Ray SD, Balasubramanian G, Bagchi D et al. Ca(2+)-calmodulin antagonist chlorpromazine and poly(ADP-ribose) polymerase modulators 4-aminobenzamide and nicotinamide influence hepatic expression of BCL-XL and P53 and protect against acetaminophen-induced programmed and unprogrammed cell death in mice. Free Radic Biol Med 2001; 31(3):277–91.

    Article  PubMed  CAS  Google Scholar 

  96. Cuzzocrea S, McDonald MC, Mazzon E et al. Effects of 5-aminoisoquinolinone, a water-soluble, potent inhibitor of the activity of poly (ADP-ribose) polymerase, in a rodent model of lung injury. Biochem Pharmacol 2002; 63(2):293–304.

    Article  PubMed  CAS  Google Scholar 

  97. Fujita T, Maruyama M, Araya J et al. Hydrogen peroxide induces upregulation of Fas in human airway epithelial cells via the activation of PARP-p53 pathway. Am J Respir Cell Mol Biol 2002; 27(5):542–52.

    PubMed  CAS  Google Scholar 

  98. Liaudet L, Szabo E, Timashpolsky L et al. Suppression of poly (ADP-ribose) polymerase activation by 3-aminobenzamide in a rat model of myocardial infarction: Long-term morphological and functional consequences. Br J Pharmacol 2001; 133(8):1424–30.

    Article  PubMed  CAS  Google Scholar 

  99. Pieper AA, Walles T, Wei G et al. Myocardial postischemic injury is reduced by polyADPripose polymerase-1 gene disruption. Mol Med 2000; 6(4):271–82.

    PubMed  CAS  Google Scholar 

  100. Varbiro G, Toth A, Tapodi A et al. Protective effect of amiodarone but not N-desethylamiodarone on postischemic hearts through the inhibition of mitochondrial permeability transition. J Pharmacol Exp Ther 2003; 307(2):615–25.

    Article  PubMed  CAS  Google Scholar 

  101. Kim GT, Chun YS, Park JW et al. Role of apoptosis-inducing factor in myocardial cell death by ischemia-reperfusion. Biochem Biophys Res Commun 2003; 309(3):619–24.

    Article  PubMed  CAS  Google Scholar 

  102. Martin DR, Lewington AJ, Hammerman MR et al. Inhibition of poly(ADP-ribose) polymerase attenuates ischemic renal injury in rats. Am J Physiol Regul Integr Comp Physiol 2000; 279(5):R1834–40.

    PubMed  CAS  Google Scholar 

  103. Ruchalski K, Mao H, Singh SK et al. HSP72 inhibits apoptosis-inducing factor release in ATP-depleted renal epithelial cells. Am J Physiol Cell Physiol 2003; 285(6):C1483–93.

    PubMed  CAS  Google Scholar 

  104. Li F, Mao HP, Ruchalski KL et al. Heat stress prevents mitochondrial injury in ATP-depleted renal epithelial cells. Am J Physiol Cell Physiol 2002; 283(3):C917–26.

    PubMed  CAS  Google Scholar 

  105. Rosenthal DS, Simbulan-Rosenthal CM, Liu WF et al. PARP determines the mode of cell death in skin fibroblasts, but not keratinocytes, exposed to sulfur mustard. J Invest Dermatol 2001; 117(6):1566–73.

    Article  PubMed  CAS  Google Scholar 

  106. Pardo J, Perez-Galan P, Gamen S et al. A role of the mitochondrial apoptosis-inducing factor in granulysin-induced apoptosis. J Immunol 2001; 167(3):1222–9.

    PubMed  CAS  Google Scholar 

  107. Yamamoto T, Ueta E, Osaki T. Apoptosis induction by interleukin-2-activated cytotoxic lymphocytes in a squamous cell carcinoma cell line and Daudi cells-involvement of reactive oxygen species-dependent cytochrome c and reactive oxygen species-independent apoptosis-inducing factors. Immunology 2003; 110(2):217–24.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

    Suk Jin Hong, Ted M. Dawson & Valina L. Dawson

  2. Departments of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

    Suk Jin Hong

  3. Departments of Neurology and Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

    Ted M. Dawson

  4. Departments of Neurology, Neuroscience and Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

    Valina L. Dawson

Authors
  1. Suk Jin Hong
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ted M. Dawson
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Valina L. Dawson
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

Copyright information

© 2006 Landes Bioscience and Springer Science+Business Media

About this chapter

Cite this chapter

Hong, S.J., Dawson, T.M., Dawson, V.L. (2006). PARP and the Release of Apoptosis-Inducing Factor from Mitochondria. In: Poly(ADP-Ribosyl)ation. Molecular Biology Intelligence Unit. Springer, Boston, MA. https://doi.org/10.1007/0-387-36005-0_10

Download citation

Publish with us

Policies and ethics

Search

Navigation