Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
9. References
A. C. Chan, D. M. Desai and A. Weiss, The role of protein tyrosine kinases and protein tyrosine phosphatases in T cell antigen receptor signal transduction, Annu. Rev. Immunol. 12, 555–592 (1994).
E. H. Palacios and A. Weiss, Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation, Oncogene 23, 7990–8000 (2004).
N. S. van Oers and A. Weiss, The Syk/ZAP-70 protein tyrosine kinase connection to antigen receptor signalling processes, Semin. Immunol. 7, 227–236 (1995).
L. J. Berg, L. D. Finkelstein, J. A. Lucas and P. L. Schwartzberg, Tec family kinases in T lymphocyte development and function, Annu. Rev. Immunol. 23, 549–600 (2005).
X. C. Liao and D. R. Littman, Altered T cell receptor signaling and disrupted T cell development in mice lacking itk, Immunity 3, 757–769 (1995).
E. M. Schaeffer, J. Debnath, G. Yap, D. McVicar, X. C. Liao, D. R. Littman, A. Sher, H. E. Varmus, M. J. Lenardo and P. L. Schwartzberg, Requirement for Tec kinases Rlk and Itk in T cell receptor signaling and immunity, Science 284, 638–641 (1999).
K. Q. Liu, S. C. Bunnell, C. B. Gurniak and L. J. Berg, T cell receptor-initiated calcium release is uncoupled from capacitative calcium entry in Itk-deficient T cells, J. Exp. Med. 187, 1721–1727 (1998).
D. J. Fowell, K. Shinkai, X. C. Liao, A. M. Beebe, R. L. Coffman, D. R. Littman and R. M. Locksley, Impaired NFATc translocation and failure of Th2 development in Itk-deficient CD4+ T cells, Immunity 11, 399–409 (1999).
J. A. Grasis, C. D. Browne and C. D. Tsoukas, Inducible T cell tyrosine kinase regulates actin-dependent cytoskeletal events induced by the T cell antigen receptor, J. Immunol. 170, 3971–3976 (2003).
K. A. Ching, Y. Kawakami, T. Kawakami and C. D. Tsoukas, Emt/Itk associates with activated TCR complexes: role of the pleckstrin homology domain, J. Immunol. 163, 6006–6013 (1999).
H. Mano, Tec family of protein-tyrosine kinases: an overview of their structure and function, Cytokine Growth Factor Rev. 10, 267–280 (1999).
A. Andreotti, S. Bunnell, S. Feng, L. Berg and S. Schreiber, Regulatory intramolecular association in a tyrosine kinase of the Tec family, Nature 385, 93–97 (1997).
W. C. Yang, Y. Collette, J. Nunes and D. Olive, Tec kinases: a family with multiple roles in immunity, Immunity 12, 373–382 (2000).
G. O. Cory, L. MacCarthy-Morrogh, S. Banin, I. Gout, P. M. Brickell, R. J. Levinsky, C. Kinnon and R. C. Lovering, Evidence that the Wiskott-Aldrich syndrome protein may be involved in lymphoid cell signaling pathways, J. Immunol. 157, 3791–3795 (1996).
S. Bunnell, P. Henry, R. Kolluri, T. Kirchhausen, R. Rickles and L. Berg, Identification of Itk/Tsk Src homology 3 domain ligands., J. Biol. Chem. 271, 25646–25656 (1996).
K. A. Ching, J. Grasis, P. Tailor, Y. Kawakami, T. Kawakami and C. D. Tsoukas, TCR/CD3-induced activation and binding of Emt/Itk to LAT complexes; requirement for the SH2 domain, J. Immunol. 165, 256–262 (2000).
M. S. Jordan, A. L. Singer and G. A. Koretzky, Adaptors as central mediators of signal transduction in immune cells, Nat. Immunol. 4, 110–116 (2003).
L. E. Samelson, Signal transduction mediated by the T cell antigen receptor: the role of adapter proteins, Annu. Rev. Immunol. 20, 371–394 (2002).
X. Shan and R. L. Wange, Itk/Emt/Tsk activation in response to CD3 cross-linking in Jurkat T cells requires ZAP-70 and Lat and is independent of membrane recruitment, J. Biol. Chem. 274, 29323–29330 (1999).
Y. W. Su, Y. Zhang, J. Schweikert, G. A. Koretzky, M. Reth and J. Wienands, Interaction of SLP adaptors with the SH2 domain of Tec family kinases, Eur. J. Immunol. 29, 3702–3711 (1999).
D. Yablonski, M. R. Kuhne, T. Kadlecek and A. Weiss, Uncoupling of nonreceptor tyrosine kinases from PLC-gamma1 in an SLP-76-deficient T cell, Science 281, 413–416 (1998).
J. M. Penninger and G. R. Crabtree, The actin cytoskeleton and lymphocyte activation, Cell 96, 9–12 (1999).
L. J. Holsinger, I. A. Graef, W. Swat, T. Chi, D. M. Bautista, L. Davidson, R. S. Lewis, F. W. Alt and G. R. Crabtree, Defects in actin-cap formation in Vav-deficient mice implicate an actin requirement for lymphocyte signal transduction, Curr. Biol. 8, 563–572 (1998).
M. L. Dustin and J. A. Cooper, The immunological synapse and the actin cytoskeleton: molecular hardware for T cell signaling, Nature Immunology 1, 23–29 (2000).
B. Lowin-Kropf, V. S. Shapiro and A. Weiss, Cytoskeletal polarization of T cells is regulated by an immunoreceptor tyrosine-based activation motif-dependent mechanism, J. Cell. Biol. 140, 861–871 (1998).
J. A. Cooper, Effects of cytochalasin and phalloidin on actin, J. Cell. Biol. 105, 1473–1478 (1987).
D. Dombroski, R. A. Houghtling, C. M. Labno, P. Precht, A. Takesono, N. J. Caplen, D. D. Billadeau, R. L. Wange, J. K. Burkhardt and P. L. Schwartzberg, Kinase-independent functions for Itk in TCR-induced regulation of Vav and the actin cytoskeleton, J. Immunol. 174, 1385–1392 (2005).
C. M. Labno, C. M. Lewis, D. You, D. W. Leung, A. Takesono, N. Kamberos, A. Seth, L. D. Finkelstein, M. K. Rosen, P. L. Schwartzberg and J. K. Burkhardt, Itk functions to control actin polymerization at the immune synapse through localized activation of Cdc42 and WASP, Curr. Biol. 13, 1619–1624 (2003).
S. D. Heyeck, H. M. Wilcox, S. C. Bunnell and L. J. Berg, Lck phosphorylates the activation loop tyrosine of the Itk kinase domain and activates Itk kinase activity, J. Biol. Chem. 272, 25401–25408 (1997).
H. M. Wilcox and L. J. Berg, Itk phosphorylation sites are required for functional activity in primary T cells, J. Biol. Chem. 278, 37112–37121 (2003).
A. T. Miller, H. M. Wilcox, Z. Lai and L. J. Berg, Signaling through Itk promotes T helper 2 differentiation via negative regulation of T-bet, Immunity 21, 67–80 (2004).
E. S. Hwang, S. J. Szabo, P. L. Schwartzberg and L. H. Glimcher, T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3, Science 307, 430–433 (2005).
C. D. Tsoukas, J. A. Grasis, K. A. Ching, Y. Kawakami and T. Kawakami, Itk/Emt: a link between T cell antigen receptor-mediated Ca2+ events and cytoskeletal reorganization, Trends in Immunol. 22, 17–20 (2001).
H. N. Higgs and T. D. Pollard, Activation by Cdc42 and PIP(2) of Wiskott-Aldrich syndrome protein (WASp) stimulates actin nucleation by Arp2/3 complex, J. Cell. Biol. 150, 1311–1320. (2000).
A. S. Kim, L. T. Kakalis, N. Abdul-Manan, G. A. Liu and M. K. Rosen, Autoinhibition and activation mechanisms of the Wiskott-Aldrich syndrome protein, Nature 404, 151–158 (2000).
G. O. Cory, R. Garg, R. Cramer and A. J. Ridley, Phosphorylation of tyrosine 291 enhances the ability of WASp to stimulate actin polymerization and filopodium formation. Wiskott-Aldrich Syndrome protein, J. Biol. Chem. 277, 45115–45121 (2002).
K. Badour, J. Zhang, F. Shi, Y. Leng, M. Collins and K. A. Siminovitch, Fyn and PTP-PEST-mediated regulation of Wiskott-Aldrich syndrome protein (WASp) tyrosine phosphorylation is required for coupling T cell antigen receptor engagement to WASp effector function and T cell activation, J. Exp. Med. 199, 99–112 (2004).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2006 Springer Science+Business Media, LLC
About this paper
Cite this paper
Tsoukas, C.D., Grasis, J.A., Browne, C.D., Ching, K.A. (2006). Inducible T Cell Tyrosine Kinase (ITK): Structural Requirements and Actin Polymerization. In: Tsoukas, C. (eds) Lymphocyte Signal Transduction. Advances in Experimental Medicine and Biology, vol 584. Springer, Boston, MA. https://doi.org/10.1007/0-387-34132-3_3
Download citation
DOI: https://doi.org/10.1007/0-387-34132-3_3
Publisher Name: Springer, Boston, MA
Print ISBN: 978-0-387-31335-1
Online ISBN: 978-0-387-34132-3
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)