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Regulation of DNA Replication by the Retinoblastoma Tumor Suppressor Protein

  • Chapter
Rb and Tumorigenesis

Part of the book series: Molecular Biology Intelligence Unit ((MIUN))

Summary

RB is a critical tumor suppressor targeted at high frequency in human cancers. As part of its mode of action RB participates in the regulation of DNA replication. In the absence of functional RB aberrant replication cycles occur and genotoxic stresses are compromised for inhibiting of DNA replication. Varied mechanisms through which RB inhibits S-phase have been described and provide evidence for temporally regulated stalling of replication initiation followed by a stable replicative exit.

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  1. Department of Cell Biology, University of Cincinnati College of Medicine, Vontz Center for Molecular Studies, Cincinnati, Ohio, 45267, USA

    Erik S. Knudsen

  2. Department of Molecular Genetics and Microbiology Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina, USA

    Steven P. Angus

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Knudsen, E.S., Angus, S.P. (2006). Regulation of DNA Replication by the Retinoblastoma Tumor Suppressor Protein. In: Rb and Tumorigenesis. Molecular Biology Intelligence Unit. Springer, Boston, MA. https://doi.org/10.1007/0-387-33915-9_3

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