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Regulation of Early Events in Cell Cycle Progression by Hedgehog Signaling in CNS Development and Tumorigenesis

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Hedgehog-Gli Signaling in Human Disease

Part of the book series: Molecular Biology Intelligence Unit ((MBIU))

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Abstract

Hedgehog signaling is essential for proliferation of neural precursor populations in the developing central nervous system (CNS) and is etiologic in cerebellar brain tumors. Here we will contrast general strategies of cell cycle regulation by growth factors in the developing CNS with the emerging concept of a noncanonical Hedgehog “proliferative pathway” as suggested by published studies. Mechanisms utilized by Sonic hedgehog signaling to promote cell cycle progression in CNS progenitors during development and in adult stem cell populations also contribute to CNS tumorigenesis.

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  1. Department of Pediatric Oncology, Dana-Farber Cancer Institute, 44 Binney Street, Boston, Massachusetts, 02115, USA

    Anna Marie Kenney & David H. Rowitch

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Kenney, A.M., Rowitch, D.H. (2006). Regulation of Early Events in Cell Cycle Progression by Hedgehog Signaling in CNS Development and Tumorigenesis. In: Hedgehog-Gli Signaling in Human Disease. Molecular Biology Intelligence Unit. Springer, Boston, MA. https://doi.org/10.1007/0-387-33777-6_15

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