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Molecular Basis of Muscle Structure

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Muscle Development in Drosophila

Part of the book series: Molecular Biology Intelligence Unit ((MBIU))

Abstract

The flight muscle myofibril is a precisely assembled cytoskeletal network of contractile proteins that produces high power to sustain flight. This chapter will focus on myofibrillar assembly during development of the indirect flight muscles. Studies in Drosophila melanogaster have combined genetics with microscopy to elucidate the series of steps that lead to the formation of the sarcomere and the role that individual myofibrillar proteins may play in this process. Despite much progress, the broad characterization of many of the mutants’ effects has yet to uncover the mechanisms that regulate and dictate the assembly of the myofibril.

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  1. Department of Biology, University of Vermont, Burlington, Vermont, 05405, USA

    Jim O. Vigoreaux

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Vigoreaux, J.O. (2006). Molecular Basis of Muscle Structure. In: Muscle Development in Drosophila. Molecular Biology Intelligence Unit. Springer, New York, NY. https://doi.org/10.1007/0-387-32963-3_12

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