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The Mitochondrial Protein Import Machinery

  • Chapter
Protein Movement Across Membranes

Part of the book series: Molecular Biology Intelligence Unit ((MBIU))

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Abstract

Mitochondria are surrounded by a double-membrane system that defines four intra-organelle compartments: the outer membrane, the inner membrane, the intermembrane space and the matrix. Hundreds of nuclear-encoded mitochondrial proteins are synthesized as precursor proteins in the cytosol and have to be targeted to and imported into the mitochondria. To facilitate this import process, precursor proteins contain targeting and sorting sequences which are recognized and decoded by mitochondrial translocation machineries. This chapter describes the mechanisms by which mitochondrial precursor proteins are targeted to the mitochondria, and sorted into the correct sub-mitochondrial compartment.

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    Doron Rapaport

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Rapaport, D. (2005). The Mitochondrial Protein Import Machinery. In: Protein Movement Across Membranes. Molecular Biology Intelligence Unit. Springer, Boston, MA. https://doi.org/10.1007/0-387-30871-7_9

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