5. Conclusion
In this study, we developed a promising antiatherogenic antioxidant, TX-2012 based on isoprenomics. The inhibitory potency of our artepillin C analogues for LDL oxidation depends not only on the lipophilicity and free radical scavenging activity, but also on the topological properties such as linearity and compactness required for LDL interaction.
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Uto, Y., Ae, S., Hotta, A., Terao, J., Nagasawa, H., Hori, H. (2006). Artepillin C Isoprenomics: Design and Synthesis of Artepillin C Analogues as Antiatherogenic Antioxidants. In: Cicco, G., Bruley, D.F., Ferrari, M., Harrison, D.K. (eds) Oxygen Transport to Tissue XXVII. Advances in Experimental Medicine and Biology, vol 578. Springer, Boston, MA . https://doi.org/10.1007/0-387-29540-2_18
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