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Impact of Hemorheological and Endothelial Factors on Microcirculation

  • Conference paper
Oxygen Transport to Tissue XXVII

Part of the book series: Advances in Experimental Medicine and Biology ((volume 578))

1. Abstract

Previous studies showed that endothelial alterations caused by physical stress worsened the hemorheological parameters mainly in patients affected by ischemic vascular diseases: major vascular alterations have been found in patients with very high endothelial dysfunction indexes: these indexes are given by the various substances produced by the endothelium, but it is very difficult to have a value which clearly identifies the real state of the endothelial alteration. The function of the NO, an endogenous vasodilator whose synthesis is catalyzed by NOs, can be determined by the Citrulline/Arginine ratio, which represents the level of activity of the enzyme. A very good index of the endothelial dysfunction is asymmetric dimethylarginine (ADMA), a powerful endogenous inhibitor of NOs; in fact several studies have demonstrated a strong relationship between ischemic vascular disease and high levels of plasmatic ADMA. Our recent studies on heart failure and on ischemic cerebrovascular diseases evaluate endothelial dysfunctions and hemorheological parameters.

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Author information

Authors and Affiliations

  1. Dipartimento di Medicina Interna, Cardiovascolare e Geriatrica -Università degli Studi di Siena, Policlinico Santa Maria alle Scotte, 53100, Siena, Italy

    Vera Turchetti

Authors
  1. Vera Turchetti
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  2. Letizia Boschi
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  3. Giovanni Donati
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  4. Luca Trabalzini
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  5. Sandro Forconi
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Editor information

Editors and Affiliations

  1. C.E.M.O.T.—Centro Interdipantimentale di Ricerca in Emoreologia, Microcircolazione, Transporto di Ossigeno e Tecnologie Ottiche non Invasive, Università di Bari, Bari, Italy, 70124

    Giuseppe Cicco

  2. College of Engineering, University of Maryland Baltimore County, Baltimore, MD, 21250, USA

    Duane F. Bruley

  3. Dip. Di Scienze e Tecnologie Biomediche, Università de L’Aquila, L’Aquila, Italy, 67100

    Marco Ferrari

  4. Regional Medical Physics Department, University Hospital of North Durham, Durham, UK, DH1 5TW

    David K. Harrison

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Turchetti, V., Boschi, L., Donati, G., Trabalzini, L., Forconi, S. (2006). Impact of Hemorheological and Endothelial Factors on Microcirculation. In: Cicco, G., Bruley, D.F., Ferrari, M., Harrison, D.K. (eds) Oxygen Transport to Tissue XXVII. Advances in Experimental Medicine and Biology, vol 578. Springer, Boston, MA . https://doi.org/10.1007/0-387-29540-2_17

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