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The TREMS: A Multifaceted Family of Immunoreceptors

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Yearbook of Intensive Care and Emergency Medicine 2005

Part of the book series: EN]Yearbook of Intensive Care and Emergency Medicine ((volume 2005))

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References

  1. Diefenbach A, Raulet DH (2003) Innate immune recognition by stimulatory immunoreceptors. Curr Opin Immunol 15:37–44

    Article  PubMed  Google Scholar 

  2. Kubagawa H, Burrows PD, Cooper MD (1997) A novel pair of immunoglobulin-like receptors expressed by B cells and myeloid cells. Proc Natl Acad Sci USA 94:5261–5266

    Article  PubMed  Google Scholar 

  3. Cantoni C, Bottino C, Vitale M, et al (1999) NKp44, a triggering receptor involved in tumor cell lysis by activated human natural killer cells, is a novel member of the immunoglobulin superfamily. J Exp Med 189:787–796

    Article  PubMed  Google Scholar 

  4. Dietrich J, Cella M, Seiffert M, Buhring HJ, Colonna M (2000) Cutting edge: signal-regulatory protein 1 is a DAP12-associated activating receptor expressed on myeloid cells. J Immunol 164:9–12

    PubMed  Google Scholar 

  5. Bouchon A, Dietrich J, Colonna M (2000) Cutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes. J Immunol 164:4991–4995

    PubMed  Google Scholar 

  6. Daws MR, Lanier LL, Seaman WE, Ryan JC (2001) Cloning and characterization of a novel mouse myeloid DAP12-associated receptor family. Eur J Immunol 31:743–791

    Article  PubMed  Google Scholar 

  7. Chung DH, Seaman WE, Daws MR (2002) Characterization of TREM-3, an activating receptor on mouse macrophages: definition of a family of single Ig domain receptors on mouse chromosome 17. Eur J Immunol 32:59–66

    Article  PubMed  Google Scholar 

  8. Bouchon A, Hernandez-Munain C, Cella M, Colonna M (2001) A DAP12-mediated pathway regulates expression of CC chemokine receptor 7 and maturation of human dendritic cells. J Exp Med 194:1111–1122

    Article  PubMed  Google Scholar 

  9. Lanier LL, Bakker AB (2000) The ITAM-bearing transmembrane adaptor DAP12 in lymphoid and myeloid cell function. Immunol Today 21:611–614

    Article  PubMed  Google Scholar 

  10. Colonna M (2003) TREMs in the immune system and beyond. Nature Rev Immunol 3:1–9

    Article  Google Scholar 

  11. McVicar DW, Taylor LS, Gosselin P, et al (1998) DAP12-mediated signal transduction in natural killer cells. A dominant role for the Syk protein-tyrosine kinase. J Biol Chem 273:32934–32942

    Article  PubMed  Google Scholar 

  12. Radaev S, Kattah M, Rostro B, et al (2004) Crystal structure of the human myeloid cell activating receptor TREM-1. Structure 11:1527–1535

    Google Scholar 

  13. Kelker MS, Foss TR, Peti W, et al (2004) Crystal structure of human triggering receptor expressed on myeloid cells 1 (TREM-1) at 1.47 Å. J Mol Biol 342:1237–1248

    Article  PubMed  Google Scholar 

  14. Colonna M, Fachetti F (2003) TREM-1: a new player in acute inflammatory responses. J Infect Dis 187(suppl 2):S397–S401

    PubMed  Google Scholar 

  15. Bouchon A, Fachetti F, Weigand MA, et al (2001) TREM-1 amplifies inflammation and is a crucial mediator of septic shock. Nature 410:1103–1107

    Article  PubMed  Google Scholar 

  16. Bleharski JR, Kiessler V, Buonsanti C, et al (2003) A role for triggering receptor expressed on myeloid cells-1 in host defense during the early-induced and adaptive phases of the immune response. J Immunol 170:3812–3818

    PubMed  Google Scholar 

  17. Radsak MP, Salih HR, Rammensee HG, et al (2004) Triggering receptor expressed on myeloid cells-1 in neutrophil inflammatory responses: differential regulation of activation and survival. J Immunol 172:4956–4963

    PubMed  Google Scholar 

  18. Lucas M, Lucas M, Daniel L, et al (2002) Massive inflammatory syndrome and lymphocytic immunodeficiency in KARAP/DAP12-transgenic mice. Eur J Immunol 32:2653–2663

    Article  PubMed  Google Scholar 

  19. Gibot S, Kolopp-Sarda MN, Bene MC, et al (2004) Régulation d'expression de TREM-1 au cours du sepsis experimental. Réanimation 13(suppl 1):180 (abst)

    Google Scholar 

  20. Knapp S, Gibot S, de Vos A, et al (2004) Cutting edge: expression patterns of surface and soluble triggering receptor expressed on myeloid cells-1 in human endotoxemia. J Immunol 173:7131–7134

    PubMed  Google Scholar 

  21. Passini N, Mariani M, Biffi M, et al (2004) Expression of TREM-1 ligand on neutrophils provides a potential diagnostic tool in sepsis. Shock 21(suppl 1):418

    Google Scholar 

  22. Gibot S, Kolopp-Sarda MN, Bene MC, et al (2004) Plasma level of a triggering receptor expressed on myeloid cells-1: Its diagnostic accuracy in patients with suspected sepsis. Ann Intern Med 141:9–15

    PubMed  Google Scholar 

  23. Gibot S, Cravoisy A, Levy B, et al (2004) Soluble triggering receptor expressed on myeloid cells and the diagnosis of pneumonia. N Engl J Med 350:451–458

    Article  PubMed  Google Scholar 

  24. Richeldi L, Mariani M, Losi M, et al (2004) Triggering receptor expressed on myeloid cells: role in the diagnosis of lung infections. Eur Respir J 24:247–250

    Article  PubMed  Google Scholar 

  25. Gibot S, Kolopp-Sarda MN, Bene MC, et al (2004) A soluble form of the triggering receptor expressed on myeloid cells-1 modulates the inflammatory response in murine sepsis. J Exp Med 200:1419–1426

    Article  PubMed  Google Scholar 

  26. Gingras MC, Lapillonne H, Margolin JF (2002) TREM-1, MDL-1, and DAP12 expression is associated with a mature stage of myeloid development. Mol Immunol 38:817–824

    PubMed  Google Scholar 

  27. Begun NA, Ishii K, Kurita-Taniguchi M (2004) Mycobacterium bovis BCG cell wall-specific differentially expressed genes identified by differential display and cDNA substraction in human macrophages. Infect Immun 12:937–948

    Article  Google Scholar 

  28. Washington AV, Quigley L., McVicar DW (2002) Initial characterization of TREM-like transcript (TLT)-1: a putative inhibitory receptor within the TREM cluster. Triggering receptors expressed on myeloid cells. Blood 100:3822–3824

    Article  PubMed  Google Scholar 

  29. Barrow AD, Astoul E, Floto A, et al (2004) Cutting edge: TREM-like transcript, a platelet immunoreceptor tyrosine-based inhibition motif encoding costimulatory immunoreceptor that enhances, rather than inhibits, calcium signalling via SHP-2. J Immunol 172:5838–5842

    PubMed  Google Scholar 

  30. Washington AV, Schubert RL, Quigley L, et al (2004) TREM family member, TLT-1, is found exclusively in the a-granules of megakaryocytes and platelets. Blood 104:1042–1047

    Article  PubMed  Google Scholar 

  31. Paloneva J, Manninen T, Christman G, et al (2002) Mutations in two genes encoding different subunits of a receptor signaling complex result in an identical disease phenotype. Am J Hum Genet 71:656–662

    Article  PubMed  Google Scholar 

  32. Schmid CD, Sautkulis LN, Danielson PE, et al (2002) Heterogeneous expression of the triggering receptor expressed on myeloid cells-2 on adult murine microglia. J Neurochem 83:1309–1320

    PubMed  Google Scholar 

  33. Kaifu T, Nakahara J, Inui M, et al (2003) Osteopetrosis and thalamic hypomyelinosis with synaptic degeneration in DAP12-deficient mice. J Clin Invest 111:323–332

    PubMed  Google Scholar 

  34. Cella M, Buonsanti C, Strader C, Kondo T, Salmaggi A, Colonna M (2003) Impaired differentiation of osteoclasts in TREM-2-deficient individuals. J Exp Med 198:645–651

    Article  PubMed  Google Scholar 

  35. Daws MR, Sullam PM, Niemi EC, Chen TT, Tchao NK, Seaman WE (2003) Pattern recognition by TREM-2: binding of anionic ligands. J Immunol 171:594–599

    PubMed  Google Scholar 

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Authors
  1. S. Gibot
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  2. B. Levy
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Editor information

Editors and Affiliations

  1. Department of Intensive Care Erasme Hospital, Free University of Brussels, Route de Lennik 808, B-1070, Brussels, Belgium

    Jean-Louis Vincent (Head) (Head)

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© 2005 Springer-Verlag Berlin Heidelberg

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Gibot, S., Levy, B. (2005). The TREMS: A Multifaceted Family of Immunoreceptors. In: Vincent, JL. (eds) Yearbook of Intensive Care and Emergency Medicine 2005. EN]Yearbook of Intensive Care and Emergency Medicine, vol 2005. Springer, New York, NY. https://doi.org/10.1007/0-387-26272-5_33

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  • DOI: https://doi.org/10.1007/0-387-26272-5_33

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-3-540-23476-0

  • Online ISBN: 978-0-387-26272-7

  • eBook Packages: MedicineMedicine (R0)

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