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A Hippocampal-Based Biosensor for Neurotoxins Detection and Classification Using a Novel Short-Term Plasticity Quantification Method

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Advances in Network Electrophysiology

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References

  • Abbot, L.F., Varela, J.A., Sen, K., and Nelson, S.B. (1997). Synaptic depression and cortical gain control. Science 275: 220–224.

    Article  Google Scholar 

  • Alberston, T.E., Walby, W.F., Stark, L.G., and Joy, R.M. (1996). The effect of propofol on the CA1 pyramidal cell excitability and GABA-A mediated inhibition in the rat hippocampal slice. Life Sci. 58(26): 2397–2407.

    Article  Google Scholar 

  • Alger, B.E. and Teyler, T.J. (1976). Long-term and short-term plasticity in the CA1, CA3, and dentate regions of the rat hippocampal slice. Brain Res. 110(3): 463–480.

    Article  PubMed  CAS  Google Scholar 

  • Ameri, A., Wilhelm, A., and Simmet, T. (1999). Effects of the endogenous cannbinoid anadamide on neuronal activity in rat hippocampal slices. Brit. J. Pharmacol. 126(8): 1831–1839.

    Article  CAS  Google Scholar 

  • Andersen, P., Bliss, T.V.P., and Skrede, K.K. (1971). Lamellar organization of hippocampal excitatory pathways. Exp. Brain Res. 13: 208–211.

    PubMed  CAS  Google Scholar 

  • Andreasen, M., Lambert, J.D., and Jensen, M.S. (1989). Effects of new non-N-methyl-Daspartate antagonists on synaptic transmission in the in vitro rat hippocampus. J. Physiol. 414: 317–336.

    Article  PubMed  CAS  Google Scholar 

  • Augustine, G.J., and Charlton, M.P. (1986). Calcium dependence of presynaptic calcium current and post-synaptic response at the squid giant synapse. J. Physiology. 381: 619–640.

    CAS  Google Scholar 

  • Augustine, G.J., Charlton, M.P., and Smith, S.J. (1985). Calcium entry and transmitter release at voltage-clamped nerve terminals of squid. J. Physiology. 367: 163–181.

    CAS  Google Scholar 

  • Bahr, B.A. (1995). Long-term hippocampal slices: A model system for investigating synaptic mechanisms and pathologic processes. J. Neurosci. Res. 42(3): 294–305, Oct 15.

    Article  PubMed  CAS  Google Scholar 

  • Baudry, M., Arst, D., Oliver, M., and Lynch, G. (1981). Development of glutamate binding sites and their regulation by calcium in rat hippocampus. Brain Res. 227(1): 37–48.

    PubMed  CAS  Google Scholar 

  • Berger, T.W., Eriksson, J.L., Ciarolla, D.A., and Scalabassi, R.J. (1988a). Nonlinear systems analysis of the hippocampal perforant path-dentate projection. II Effects of random train stimulation. J. Neurophsiol. 60: 1077–1094.

    Google Scholar 

  • Berger, T.W., Eriksson, J.L., Ciarolla, D.A., and Scalabassi, R.J. (1988b). Nonlinear systems analysis of the hippocampal perforant path-dentate projection. III Comparison of random train and paired impulse stimulation. J. Neurophsiol. 60: 1095–1109.

    CAS  Google Scholar 

  • Berger, T.W., Harty, T.P., Barrionuevo, G., and Scalabassi, R.J. (1989). Modeling of neuronal networks through experimental decomposition In: Maramarelis, V.Z., ed., Advanced Methods of Physiological System Modeling, Vol. II. Plenum Press, New York, pp. 113–128.

    Google Scholar 

  • Berger, T.W., Robinson, G.B., Port, R.L., and Scalabassi, R.J. (1987). Nonlinear systems analysis for the functional properties of the hippocampal formation. In: Maramarelis, V.Z., ed., Advanced Methods of Physiological System Modeling, Vol. I., Biomedical Simulation Resource, Los Angeles, 73–103.

    Google Scholar 

  • Bliss, T.V.P. and Lomo, T. (1973). Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path. J. Neurophysiol. 232: 331–356.

    CAS  Google Scholar 

  • Buonomano, D.V. (1999). Distinct functional types of associative long-term potentiation in the neocortical and hippocampal pyramidal neurons. J. Neurosci. 19(16): 6748–6754.

    PubMed  CAS  Google Scholar 

  • Buonomano, D.V. (2000). Decoding temporal information: A model based on short-term synaptic plasticity. J. Neurosci. 20(3): 1129–1141.

    PubMed  CAS  Google Scholar 

  • Castellucci, V.F. and Kandel, E.R. (1974). A quantal analysis of the synaptic depression underlying habituation of the gill-withdrawal reflex in Aplysia. Proc. Natl. Acad. Sci. U. S. A. 71(12): 5004–5008.

    Article  PubMed  CAS  Google Scholar 

  • Castro-Alamancos, M.A., and Connors, B.W. (1997). Distinct forms of short-term plasticity at excitatory synapses of hippocampus and neocortex. Proc. Natl. Acad. Sci. U. S. A. 94: 4161–4166.

    Article  PubMed  CAS  Google Scholar 

  • Colmers, W.F., Lukowiak, K., and Pittman, Q.J. (1985). NeuropeptideYreduces orthidromically evoked population spike in rat hippocampal CA1 by a possibly presynaptic mechanism. Brain Res. 346(2): 404–408.

    Article  PubMed  CAS  Google Scholar 

  • Courellis, S.H., Marmarelis, V.Z., and Berger, T.W. (2000). Modeling event-driven nonlinear dynamics in neuronal systems with multiple inputs, Annual Conference Biomedical Engineering Society, Seattle, WA.

    Google Scholar 

  • Creager, R., Dunwiddie, T., and Lynch, G. (1980). Paired-pulse and frequency facilitation in the CA1 region of the in vitro rat hippocampus. J. Neurophysiol. 299: 409–424.

    CAS  Google Scholar 

  • Davies, C.H., Davies, S.N., and Collingridge, G.L. (1990). Paired pulse depression of monosynaptic GABA-mediated inhibitory postsynaptic responses in rat hippocampus. J. Neurophysiol. 424: 513–31.

    CAS  Google Scholar 

  • Dobrunz, L.E., Huang, E.P., and Stevens, C.F. (1997). Very short-term plasticity in hippocampal synapses. Proc. Natl. Acad. Sci. U. S. A. 94: 14843–14847.

    Article  PubMed  CAS  Google Scholar 

  • Egert, U., Schlosshauer, B., Fennrich, S., Nisch, W., Fejtl, M., Knott, T., Muller, T., and Hammerle, H. (1998). A novel organotypic long-term culture of the rat hippocampus on substrate-integrated multielectrode arrays. Brain Res. Protocols 2: 229–242.

    Article  CAS  Google Scholar 

  • Fortune, E.S. and Rose, G.R. (2000). Short-term synaptic plasticity contributes to the temporal filtering of electrosensory information. J. Neurosci. 20(18): 7122–7130.

    PubMed  CAS  Google Scholar 

  • Fountain, S.B. and Teyler, T.J. (1995). Brain slice techniques in neurotoxicology. In Chang, L.W. and Slikker, W., eds., Neurotoxicology: Approaches and Methods. Academic Press, New York, pp. 517–535.

    Google Scholar 

  • Franceschetti, S., Hamon, B., and Heinemann, U. (1986). The action of valproate on spontaneous epileptiform activity in the absence of synaptic transmission and on evoked changes in [Ca2+]o and [K+]o in the hippocampal slice. Brain Res. 386(1–2): 1–11.

    Article  PubMed  CAS  Google Scholar 

  • Fueta, Y., Ohno, K., and Mita, T. (1998). Large frequency potentiation induced by 2 Hz stimulation in the hippocampus of epileptic El mice. Brain Res. 792(1): 79–88.

    Article  PubMed  CAS  Google Scholar 

  • Gahwiler, B.H. (1981). Organotypic monolayer cultures of nervous tissue. J. Neurosci. Meth. 4, 329–342.

    Article  CAS  Google Scholar 

  • Galarreta, M. and Hestrin, S. (1998). Frequency-dependent synaptic depression and the balance of excitation and inhibition in the neocortex. Natl. Am. 1(7): 587594.

    Google Scholar 

  • Gholmieh, G., Courellis, S., Dimoka, A., Marmarelis, V.Z., and Berger, T.W. (2004). A real time EPSP and spike amplitude extraction method. J. Neurosci. Meth. 136(2): 111–121.

    Article  Google Scholar 

  • Gholmieh, G., Courellis, S., Fakheri, S., Cheung, E., Marmarelis, V.Z., Baudry, M., and Berger, T.W. (2003). Detection and classification of neurotoxins using a novel short-term plasticity quantification method. Biosens. Bioelectron. 18(12): 1467–1478.

    Article  PubMed  CAS  Google Scholar 

  • Gholmieh, G., Courellis, S., Marmarelis, V.Z., and Berger, T.W. (2002). An efficient method for studying short-term plasticity with random impulse train stimuli. J. Neurosci. Meth. 121(2): 111–127.

    Article  Google Scholar 

  • Gholmieh, G., Courellis, S., Marmarelis, V.Z., and Berger, T.W. (2005). Detecting CA1 short-term plasticity variations associated with changes in stimulus intensity and extracellular medium composition. J. Neurocomput.

    Google Scholar 

  • Gholmieh, G., Soussou, W., Courellis, S., Marmarelis, V.Z., Berger, T.W, and Baudry, M. (2001). A biosensor for detecting changes in cognitive processing based on non-linear system analysis. Biosens. Bioelectron. 16(7–8): 491–50.

    Article  PubMed  CAS  Google Scholar 

  • Gross, G.W., Rhoadas, B.K., Reust, D.L., and Schwalm F.U. (1993). Stimulation of monolayer networks in culture through thin film indium-tin oxide recording electrodes. J. Neurosci. Meth. 50 131–143.

    Article  CAS  Google Scholar 

  • Harris, K.M. and Teyler, T.J. (1983). Age differences in a circadian influence on hippocampal LTP. Brain Res. 261(1): 69–73.

    Article  PubMed  CAS  Google Scholar 

  • Harris, E.W., Ganong, A.H., and Cotman, C.W. (1984). Long-term potentiation in the hippocampus involves activation of N-methyl-D-aspartate receptors. Brain Res. 323(1): 132–137.

    Article  PubMed  CAS  Google Scholar 

  • Hesen, W., Karten, Y.J., van de Witte, S.V., and Joels, M. (1998). Serotonin and carbachol induced suppression of synaptic excitability in rat CA1 hippocampal area: Effects of corticosteroid receptor activation. J. Neuroendocrinol. 10(1): 9–19.

    Article  PubMed  CAS  Google Scholar 

  • Higgins, G.M. and Gardier, R.W. (1990). Gamma-Aminobutyric acid antagonism produced by an organophosphate-containing combustion product. Toxicol. Appl. Pharmacol. 105(1): 103–112.

    Article  PubMed  CAS  Google Scholar 

  • Huang, Y.Y. and Malenka, R.C. (1993). Examination of TEA-induced synaptic enhancement in area CA1 of the hippocampus: The role of voltage-dependent Ca2+ channels in the induction of LTP. J. Neurosci. 13(2): 568–576.

    PubMed  CAS  Google Scholar 

  • Igelmund, P. and Heinemann, U. (1995). Synaptic transmission and paired pulse behaviour of CA1 pyramidal cells in hippocampal slices from a hibernator at low temperature: Importance of ionic environment. Brain Res. 689(1): 9–20.

    Article  PubMed  CAS  Google Scholar 

  • Kao, W.Y., Liu, Q.Y., Ma, W., Ritchie, G.D., Lin, J., Nordholm, A.F., Rossi, J., 3rd, Barker, J.L., Stenger, D.A., and Pancrazio, J.J. (1999). Inhibition of spontaneous GABAergic transmission by trimethylolpropane phosphate. Neurotoxicology 20(5): 843–849.

    PubMed  CAS  Google Scholar 

  • Katz, B. and Miledi, R. (1968). The role of calcium in neuromuscular facilitation. J. Physiol. 195(2): 481–92.

    PubMed  CAS  Google Scholar 

  • Keefer, E.W., Gramowski, A., Stenger, D.A., Pancrazio, J.J., and Gross, G.W. (2001). Characterization of acute neurotoxic effects of trimethylolpropane phosphate via neuronal network biosensors. Biosens. Bioelectron. 16(7–8): 513–525.

    Article  PubMed  CAS  Google Scholar 

  • Konig, P., Engel, A.K., and Singer, W. (1996). Integrator or coincidence detector? The role of the cortical neuron revisited. Trends Neurosci. 19: 130–137.

    Article  PubMed  CAS  Google Scholar 

  • Krausz, H.I. and Friesen, W.O. (1975). Identification of nonlinear systems using random impulse train inputs. Biol. Cybern. 19: 217–230.

    Article  Google Scholar 

  • Krugers, H.J., Mulder, M., Korf, J., Havekes, L., DeKloet, E.R., and Joels, M. (1997). Altered synaptic plasticity in hippocampal CA1 area of apolipoprotein E deficient mice. Neuroreport 8(11): 2505–2510.

    PubMed  CAS  Google Scholar 

  • Landfield, P.W., Pitler, T.A., and Applegate, M.D. (1986). The effects of high Mg2+−to-Ca2+ ratios on frequency potentiation in hippocampal slices of young and aged rats. J. Neurophysiol. 56(3): 797–811.

    PubMed  CAS  Google Scholar 

  • Lee, Y.W. and Schetzen, M. (1965). Measurement of the kernels of a non-linear system by cross-correlation. Int. J. Control 2: 237–254.

    Google Scholar 

  • Leung, L.S. and Fu, X.W. (1994). Factors affecting paired-pulse facilitation in the hippocampal CA1 neurons in vitro. Brain Res. 650: 75–84.

    Article  PubMed  CAS  Google Scholar 

  • Lin, J., Cassell, J., Ritchie, G.D., Rossi, J., 3rd, and Nordholm, A.F. (1998). Repeated exposure to trimethylolpropane phosphate induces central nervous system sensitization and facilitates electrical kindling. Physiol. Behav. 65(1): 51–58.

    Article  PubMed  CAS  Google Scholar 

  • Lin, J., Ritchie, G.D., Stenger, D.A., Nordholm, A.F., Pancrazio, J.J., and Rossi, J., 3rd, Ritchie (2001). Trimethylolpropane phosphate induces epileptiform discharges in the CA1 region of the rat hippocampus. Toxi. Appl. Pharmacol. 171(2): 126–134.

    Article  CAS  Google Scholar 

  • Marmarelis, V.Z. (1993). Identification of nonlinear biological systems using Laguerre expansions of kernels. Ann. Biomed. Eng. 21: 573–589.

    Article  PubMed  CAS  Google Scholar 

  • Meyer, J.H., Lee, S., Wittenberg, G.F., Randall, R.D., and Gruol, D.L. (1999). Neurosteroid regulation of inhibitory synaptic transmission in the rat hippocampus. Neuroscience 90(4): 1177–1183.

    Article  PubMed  CAS  Google Scholar 

  • Muller, D. and Lynch, G. (1990). Synaptic modulation of N-Methyl-D-aspartate receptor mediated responses in hippocampus. Synapse 5: 94–103.

    Article  PubMed  CAS  Google Scholar 

  • Nelson, T.E., Ur, C.L., and Gruol, D.L. (1999). Chronic intermittent ethanol exposure alters CA1 synaptic transmission in rat hippocampal slices. Neuroscience 94(2): 431–442.

    Article  PubMed  CAS  Google Scholar 

  • Novak, J.L. and Wheeler, B.C. (1988). Multisite hippocampal slice recording and stimulation using a 32 element microelectrode array. J. Neurosci. Meth. 23: 149–159.

    Article  CAS  Google Scholar 

  • Oka, H., Shimono, K., Ogawa R., Sugihara, H., and Taketani, M. (1999). A new planar multielectrode array for extracellular recording: Application to hippocampal acute slice. J. Neurosci. Meth. 93: 61–67.

    Article  CAS  Google Scholar 

  • Pananceau, M., Chen, H., and Gustafsson, B. (1998). Short-term facilitation evoked during brief afferent tetani is not altered by long-term potentiation in the guinea-pig hippocampal CA1 region. J. Physiol. 508.2: 503–514.

    Article  Google Scholar 

  • Pancrazio, J.J., Gray, S.A., Shubin, Y.S., Kulagina, N., Cuttino, D.S., Shaffer, K.M., Eisemann, K., Curran, A., Zim, B., Gross, G.W., and O’Shaughnessy, T.J. (2003). A portable microelectrode array recording system incorporating cultured neuronal networks for neurotoxin detection. Biosens. Bioelectron. (18)11: 1339–1347.

    Article  PubMed  CAS  Google Scholar 

  • Papatheodoropoulos, C. and Kostopoulos, G. (2000). Dorsal-ventral differentiation of short-term synaptic plasticity in rat CA1 hippocampal region. Neurosci. Lett. 286(1):57–60.

    Article  PubMed  CAS  Google Scholar 

  • Perrett, S., Dudek, S., Eagleman, D., Montague, P., and Friedlander, M. (2001). LTD induction in adult visual cortex: Role of stimulus timing and inhibition. J. Neurosci. 21(7): 2308–2319.

    PubMed  CAS  Google Scholar 

  • Rausche, G., Igelmund, P., and Heinemann, U. (1990). Effects of changes in extracellular potassium, magnesium and calcium concentration on synaptic transmission in area CA1 and the dentate gyrus of rat hippocampal slices. Euro. J. Physiol. 415(5): 588–593.

    CAS  Google Scholar 

  • Rossi, J., 3rd, Ritchie, G.D., McInturf, S., and Nordholm, A.F. (2001). Reduction of motor seizures in rats induced by the ethyl bicyclophosphate trimethylolpropane phosphate (TMPP). Prog. Neuro-Psychopharmacol. Biol. Psychiatry 25(11.6): 1323–1340.

    Article  CAS  Google Scholar 

  • Sagratella, S., Proietti, M.L., Frank, C., and de Carolis, A.S. (1991). Effects of some calcium antagonists and of calcium concentration changes on CA1 paired pulse inhibition in rat hippocampal slices. Gen. Pharmacol. 22(2): 227–230.

    PubMed  CAS  Google Scholar 

  • Scalabassi, R.J., Eriksson, J.L, Port, R., Robinson, G., and Berger, T.W (1988). Nonlinear systems analysis of the hippocampal perforant path-dentate projection. i. Theoretical and interpretational considerations. J. Neurophysiol. 60: 1066–1076.

    Google Scholar 

  • Song, D., Xiaping, X., Wang, Z., and Berger, T.W. (2001). Differential effect of TEA on longterm synaptic modification in hippocampal CA1 and dentate gyrus in vitro. Neurobiol. Learn. Memory 76: 357–387.

    Google Scholar 

  • Southan, A.P. and Owen, D.G. (1997). The contrasting effects of dendrotoxins and other potassium channel blockers in the CA1 and dentate gyrus regions of rat hippocampal slices. Brit. J. Pharmacol. 122(2): 335–343.

    Article  CAS  Google Scholar 

  • Stanford, I.M, Wheal, H.V., and Chad, J.E. (1995). Bicuculline enhances the late GabaB receptor-mediated paired pulse inhibition observed in the rat hippocampal slices. Euro. J. Pharmacol. 277(2–3): 229–234.

    Article  CAS  Google Scholar 

  • Stringer, J.L., and Lothman, E.W. (1998). In vitro effects of extracellular calcium concentrations on hippocampal pyramidal cell responses. Exp. Neurol. 101(1): 132–146.

    Article  Google Scholar 

  • Turner, RW. and Miller J.J. (1982). Effects of extracellular calcium on lowfrequency induced potentiation and habituation in the in vitro hippocampal slice preparation. Canad. J. Physiol. Pharmacol. 60(3): 266–267.

    CAS  Google Scholar 

  • Wheal, H.V., Lancaster, B., and Bliss, T.V. (1983). Long-term potentiation in Schaffer collateral and commissural systems of the hippocampus: In vitro study in rats pretreated with kainic acid. Brain Res. 272(2): 247–253.

    Article  PubMed  CAS  Google Scholar 

  • Wheeler, B.C. and Novak, J.L. (1986). Current source density estimation using microelectrode array data from the hippocampal slice preparation. IEEE Trans. Biomed. Eng. 33(12): 1204–1212.

    PubMed  CAS  Google Scholar 

  • Xie, X., Liaw, J.S., Baudry, M., and Berger, T.W. (1997). Novel expression mechanism for synaptic potentiation: Alignment of presynaptic release site and postsynaptic receptor. Proc. Natl. Acad. Sci. U. S. A. 94(13): 6983–6988.

    Article  PubMed  CAS  Google Scholar 

  • Yajeya, J., De La Fuente, A., Criado, J.M., Bajo, V., Sanchez-Riolobos, A., and Heredia, M. (2000). Muscarinic agonist carbachol depresses excitatory synaptic transmission in the rat basolateral amygdala in vitro. Synapse 38(2): 151–160.

    Article  PubMed  CAS  Google Scholar 

  • Yamamoto, C., Matsumoto, K., and Takagi, M. (1980). Potentiation of excitatory postsynaptic potentials during and after repetitive stimulation in thin hippocampal sections. Exp. Brain Res. 38(4): 469–477.

    Article  PubMed  CAS  Google Scholar 

  • Zucker, R.S. (1989). Short-term synaptic plasticity. Ann. Rev. Neurosci. 12: 13–31.

    Article  PubMed  CAS  Google Scholar 

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Gholmieh, G., Courellis, S., Marmarelis, V., Baudry, M., Berger, T.W. (2006). A Hippocampal-Based Biosensor for Neurotoxins Detection and Classification Using a Novel Short-Term Plasticity Quantification Method. In: Taketani, M., Baudry, M. (eds) Advances in Network Electrophysiology. Springer, Boston, MA . https://doi.org/10.1007/0-387-25858-2_12

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