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Brain-Derived Neurotrophic Factor (BDNF) and the Dentate Gyrus Mossy Fibers: Implications for Epilepsy

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Synaptic Plasticity and Transsynaptic Signaling

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11. References

  • Acsady, L., Kamondi, A., Sik, A., Freund, T., and Buzsaki, G., 1998, GABAergic cells are the major postsynaptic targets of mossy fibers in the rat hippocampus. J Neurosci, 18, 3386.

    PubMed  CAS  Google Scholar 

  • Bauer, J., 2001, Interactions between hormones and epilepsy in female patients. Epilepsia, 42, 20.

    Article  PubMed  Google Scholar 

  • Bibel, M. and Barde, Y. A., 2000, Neurotrophins: key regulators of cell fate and cell shape in the vertebrate nervous system. Genes Dev., 14, 2919.

    Article  PubMed  CAS  Google Scholar 

  • Binder, D. K., Croll, S. D., Gall, C. M., and Scharfman, H. E., 2001, BDNF and epilepsy: too much of a good thing? Trends Neurosci, 24, 47.

    Article  PubMed  CAS  Google Scholar 

  • Binder, D. K., Routbort, M. J., Ryan, T. E., Yancopoulos, G. D., and McNamara, J. O., 1999, Selective inhibition of kindling development by intraventricular administration to TrkB receptor body. J Neurosci., 19, 1424.

    PubMed  CAS  Google Scholar 

  • Black, I. B., 1999, Trophic regulation of synaptic plasticity. J Neurobiol, 41, 108.

    Article  PubMed  CAS  Google Scholar 

  • Blum, R., Kafitz, K. W., and Konnerth, A., 2002, Neurotrophin-evoked depolarization requires the sodium channel Na(V)I.9. Nature, 419, 687.

    Article  PubMed  CAS  Google Scholar 

  • Blurton-Jones, M., Kuan, P. N., and Tuszynski, M. H., 2004, Anatomical evidence for transsynaptic influences of estrogen on brain-derived neurotrophic factor expression. J Comp Neurol., 468, 347.

    Article  PubMed  CAS  Google Scholar 

  • Brake, W. G., Alves, S. E., Dunlop, J. C., Lee, S. J., Bulloch, K., Allen, P. B., Greengard, P., and McEwen, B. S., 2001, Novel target sites for estrogen action in the dorsal hippocampus: an examination of synaptic proteins. Endocrinology, 142, 1284.

    Article  PubMed  CAS  Google Scholar 

  • Buckmaster, P. S., Zhang, G. F., and Yamawaki, R., 2002, Axon sprouting in a model of temporal lobe epilepsy creates a predominantly excitatory feedback circuit. J Neurosci., 22, 6650.

    PubMed  CAS  Google Scholar 

  • Chao, M. V., 2003, Neurotrophins and their receptors: a convergence point for many signalling pathways. Nat Rev Neurosci., 4, 299.

    Article  PubMed  CAS  Google Scholar 

  • Cirulli, F., Berry, A., Chiarotti, F., and Alleva, E., 2004, Intrahippocampal administration of BDNF in adult rats affects short-term behavioral plasticity in the Morris water maze and performance in the elevated plus-maze. Hippocampus, 14, 802.

    Article  PubMed  CAS  Google Scholar 

  • Conner, J. M., Lauterborn, J. C., Yan, Q., Gall, C. M., and Varon, S., 1997, Distribution of brain-derived neurotrophic factor (BDNF) protein and mRNA in the normal adult rat CNS: evidence for anterograde axonal transport. J. Neurosci., 17, 2295.

    PubMed  CAS  Google Scholar 

  • Croll, S. D., Suri, C., Compton, D. L., Simmons, M. V., Yancopoulos, G. D., Lindsay, R. M., Wiegand, S. J., Rudge, J. S., and Scharfman, H. E., 1999, Brain-derived neurotrophic factor transgenic mice exhibit passive avoidance deficits, increased seizure severity and in vitro hyperexcitability in the hippocampus and entorhinal cortex. Neuroscience, 93, 1491.

    Article  PubMed  CAS  Google Scholar 

  • Danzer, S. C., Pan, E., Nef, S., Parada, L. F., and McNamara, J. O., 2004, Altered regulation of brain-derived neurotrophic factor protein in hippocampus following slice preparation. Neuroscience, 126, 859.

    Article  PubMed  CAS  Google Scholar 

  • Deisz, R. A. and Prince, D. A., 1989, Frequency-dependent depression of inhibition in guinea-pig neocortex in vitro by GABAB receptor feed-back on GABA release. J Physiol., 412, 513.

    PubMed  CAS  Google Scholar 

  • Drake, C. T., Milner, T. A., and Patterson, S. L., 1999, Ultrastructural localization of full-length trkB immunoreactivity in rat hippocampus suggests multiple roles in modulating activity-dependent synaptic plasticity. J Neurosci, 19, 8009.

    PubMed  CAS  Google Scholar 

  • Frerking, M., Malenka, R. C., and Nicoll, R. A., 1998, Brain-derived neurotrophic factor (BDNF) modulates inhibitory, but not excitatory, transmission in the CA1 region of the hippocampus. J Neurophysiol, 80, 3383.

    PubMed  CAS  Google Scholar 

  • Galanopoulou, A. S., Kyrozis, A., Claudio, O. I., Stanton, P. K., and Moshe, S. L., 2003, Sex-specific KCC2 expression and GABA(A) receptor function in rat substantia nigra. Exp Neurol., 183, 628.

    Article  PubMed  CAS  Google Scholar 

  • Gall, C. M., 1993, Seizure-induced changes in neurotrophin expression: implications for epilepsy. Exp Neurol., 124, 150.

    Article  PubMed  CAS  Google Scholar 

  • He, X. P., Kotloski, R., Nef, S., Luikart, B. W., Parada, L. F., and McNamara, J. O., 2004, Conditional deletion of TrkB but not BDNF prevents epileptogenesis in the kindling model. Neuron., 43, 31.

    Article  PubMed  CAS  Google Scholar 

  • Herzog, A. G., Klein, P., and Ransil, B. J., 1997, Three patterns of catamenial epilepsy. Epilepsia, 38, 1082.

    Article  PubMed  CAS  Google Scholar 

  • Jovanic, J. N., Benfenati, F., Siow, Y. L., Sihra, T. S., Sanghera, J. S., Pelech, S. L., Greengard, P., and Czernik, A. J., 1996, Neurotrophins stimulate phosphorylation of synapsin I by MAP kinase and regulate synapsin I actin interactions. Proc Natl Acad Sci USA, 93, 367.

    Article  Google Scholar 

  • Kafitz, K. W., Rose, C. R., Thoenen, H., and Konnerth, A., 1999, Neurotrophin-evoked rapid excitation through TrkB receptors. Nature, 401, 918.

    Article  PubMed  CAS  Google Scholar 

  • Kanemoto, K., Kawasaki, J., Tarao, Y., Kumaki, T., Oshima, T., Kaji, R., and Nishimura, M., 2003, Association of partial epilepsy with brain-derived neurotrophic factor (BDNF) gene polymorphisms. Epilepsy Res., 53, 255.

    Article  PubMed  CAS  Google Scholar 

  • Kang, H. and Schuman, E. M., 1995, Long-lasting neurotrophin-induced enhancement of synaptic transmission in the adult hippocampus. Science, 267, 1658.

    PubMed  CAS  Google Scholar 

  • Koponen, E., Voikar, V., Riekki, R., Saarelainen, T., Rauramaa, T., Rauvala, H., Taira, T., and Castern, E., 2004, Transgenic mice overexpressing the full-length neurotrophin receptor trkB exhibit increased activation of the trkB-PLCgamma pathway, reduced anxiety, and facilitated learning. Mol Cell Neurosci., 26, 166.

    Article  PubMed  CAS  Google Scholar 

  • Korte, M., Staiger, V., Griesbeck, O., Thoenen, H., and Bonhoeffer, T., 1996, The involvement of brain-derived neurotrophic factor in hippocampal long-term potentiation revealed by gene targeting experiments. J. Physiol., 90, 157.

    CAS  Google Scholar 

  • Kotti, T., Riekkinen Sr., P. J., and Miettinen, R., 1997, Characterization of target cells for aberrant mossy fiber collaterals in the dentate gyrus of epileptic rat. Exp Neurol., 146, 323.

    Article  PubMed  CAS  Google Scholar 

  • Kovalchuk, Y., Hanse, E., Kafitz, K. W., and Konnerth, A., 2002, Postsynaptic induction of BDNF-mediated long-term potentiation. Science, 295, 1729.

    Article  PubMed  CAS  Google Scholar 

  • Lahteinen, S., Pitkanen, A., Knuuttila, J., Toronen, P., and Castren, E., 2004, Brain-derived neurotrophic factor signaling modifies hippocampal gene expression during epileptogenesis in transgenic mice. Eur J Neurosci., 19, 3245.

    Article  PubMed  Google Scholar 

  • Lahteinen, S., Pitkanen, A., Koponen, E., Saarelainen, T., and Castren, E., 2003, Exacerbated status epilepticus and acute cell loss, but no changes in epileptogenesis, in mice with increased brain-derived neurotrophic factor signaling. Neuroscience, 122, 1081.

    Article  PubMed  CAS  Google Scholar 

  • Lahteinen, S., Pitkanen, A., Saarelainen, T., Nissinen, J., Koponen, E., and Castren, E., 2002, Decreased BDNF signalling in transgenic mice reduces epileptogenesis. Eur J Neurosci., 15, 721.

    Article  PubMed  Google Scholar 

  • Larmet, Y., Reibel, S., Carnahan, J., Nawa, H., Marescaux, C., and Depaulis, A., 1995, Protective effects of brain-derived neurotrophic factor on the development of hippocampal kindling in the rat. NeuroReport, 6, 1937.

    Article  PubMed  CAS  Google Scholar 

  • Lohof, A. M., Ip, N. Y., and Poo, M. M., 1993, Potentiation of developing neuromuscular synapses by the neurotrophins NT-3 and BDNF. Nature, 363, 350.

    Article  PubMed  CAS  Google Scholar 

  • Lynch M, Sutula T., 2000, Recurrent excitatory connectivity in the dentate gyrus of kindled and kainic acid-treated rats. J Neurophysiol. 83, 693.

    PubMed  CAS  Google Scholar 

  • MacLuksy N. J., Mercurio T. C., Wilson M. A., Scharfman H. E., 2003, Changes in mossy fiber transmission across the female rat estrous cycle: role of BDNF and α7 nicotinic cholinergic receptors (α7nAChRS). Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience, Online.

    Google Scholar 

  • Marmigere, F., Givalois, L., Rage, F., Arancibia, S., and Tapia-Arancibia, L., 2003, Rapid induction of BDNF expression in the hippocampus during immobilization stress challenge in adult rats. Hippocampus, 13, 646.

    Article  PubMed  CAS  Google Scholar 

  • Mathern, G. W., Babb, T. L., Micevych, P. E., Blanco, C. E., and Pretorius, J. K., 1997, Granule cell mRNA levels for BDNF, NGF, and NT-3 correlate with neuron losses or supragranular mossy fiber sprouting in the chronically damaged and epileptic human hippocampus. Mol Chem Neuropathol, 30, 53.

    PubMed  CAS  Google Scholar 

  • Messaoudi, E., Bardsen, K., Srebro, B., and Bramham, C. R., 1998, Acute intrahippocampal infusion of BDNF induces lasting potentiation of synaptic transmission in the rat dentate gyrus. J Neurophysiol., 79, 496.

    PubMed  CAS  Google Scholar 

  • Milner, T. A., McEwen, B. S., Hayashi, S., Li, C. J., Reagan, L. P., and Alves, S. E., 2001, Ultrastructural evidence that hippocampal alpha estrogen receptors are located at extranuclear sites. J Comp Neurol, 429, 355.

    Article  PubMed  CAS  Google Scholar 

  • Mitrovic, A. D., Maddison, J. E., and Johnston, G. A., 1999, Influence of the oestrous cycle on L-glutamate and L-aspartate transport in rat brain synaptosomes. Neurochem Int, 34, 101.

    Article  PubMed  CAS  Google Scholar 

  • Monteggia, L. M., Barrot, M., Powell, C. M., Berton, O., Galanis, V., Gemelli, T., Meuth, S., Nagy, A., Greene, R. W., and Nestler, E.J., 2004, Essential role of brain-derived neurotrophic factor in adult hippocampal function. Proc Natl Acad Sci USA, 101, 10827.

    Article  PubMed  CAS  Google Scholar 

  • Murray, K. D., Isackson, P. J., Eskin, T. A., King, M. A., and Montesinos, S. P., 2000, Altered mRNA expression for brain-derived neurotrophic factor and type II calcium/calmodulin-dependent protein kinase in the hippocampus of patients with intractable temporal lobe epilepsy. J Comp Neurol, 18, 411.

    Article  Google Scholar 

  • Nadler, J. V., 2003, The recurrent mossy fiber pathway of the epileptic brain. Neurochem Res., 28, 1649.

    Article  PubMed  CAS  Google Scholar 

  • Olofsdotter, K., Lindvall, O., and Asztely, F., 2000, Increased synaptic inhibition in dentate gyrus of mice with reduced levels of endogenous brain-derived neurotrophic factor. Neuroscience, 101, 531.

    Article  PubMed  CAS  Google Scholar 

  • Oschobo, P., Adams, B., Sazgar, M., Xu, Y., Racine, R. J., and Fahnestock, M., 1999, Brain-derived neurotrophic factor infusion delays amygdala and perforant path kindling without affecting paired-pulse measures of neuronal inhibition in adult rats. Neurosci, 92, 1367.

    Article  Google Scholar 

  • Patterson, S. L., Abel, T., Deuel, T. A., Martin, K. C., Rose, J. C., and Kandel, E. R., 1996, Recombinant BDNF rescues deficits in basal synaptic transmission and hippocampal LTP in BDNF knockout mice. Neuron, 16, 1137.

    Article  PubMed  CAS  Google Scholar 

  • Reibel, S., Larmet, Y., Carnahan, J., Marescaux, C., and Depaulis, A., 2000, Endogenous control of hippocampal epileptogenesis: a molecular cascade involving brain-derived neurotrophic factor and neuropeptide Y. Epilepsia, 41, S127.

    Article  PubMed  Google Scholar 

  • Rivera, C., Voipio, J., Payne, J. A., Ruusuvuori, E., Lahtinen, H., Lamsa, K., Pirvola, U., Saarma, M., and Kaila, K., 1999, The K+/Cl-co-transporter KCC2 renders GABA hyperpolarizing during neuronal maturation. Nature, 397, 251.

    Article  PubMed  CAS  Google Scholar 

  • Rivera, C., Voipio, J., Thomas-Crusells, J., Li, H., Emri, Z., Sipila, S., Payne, J. A., Minichiello, L., Saarma, M., and Kaila, K., 2004, Mechanism of activity-dependent downregulation of the neuron-specific K-Cl cotransporter KCC2. J Neurosci., 24, 4683.

    Article  PubMed  CAS  Google Scholar 

  • Rose, C. R., Blum, R., Pichler, B., Lepier, A., Kafitz, K. W., and Konnerth, A., 2003, Truncated TrkB-T1 mediates neurotrophin-evoked calcium signalling in glia cells. Nature, 426, 74.

    Article  PubMed  CAS  Google Scholar 

  • Rudge, J. S., Mather, P. E., Pasnikowski, E. M., Cai, N., Corcoran, T., Acheson, A., Anderson, K., Lindsay, R. M., and Wiegand, S. J., 1998, Endogenous BDNF protein is increased in adult rat hippocampas after a kainic acid induced excitotoxic insult but exogenous BDNF is not protective. Expl Neurol., 149, 398.

    Article  CAS  Google Scholar 

  • Schaaf, M. J., deJong, J., deKloet, E. R., and Vreugdenhil, E., 1998, Downregulation of BDNF mRNA and protein in the rat hippocampus by corticosterone. Brain Res., 813, 112.

    Article  PubMed  CAS  Google Scholar 

  • Scharfman, H. E., 1997, Hyperexcitability in combined entorhinal/hippocampal slices of adult rat after exposure to brain-derived neurotrophic factor. J Neurophysiol, 78, 1082.

    PubMed  CAS  Google Scholar 

  • Scharfman, H. E., Goodman, J. H., Solas, A. L., and Croll, S. D., 2002a, Spontaneous limbic seizures after intrahippocampal infusion of brain-derived neurotrophic factor. Exp Neurol., 174, 201.

    Article  PubMed  CAS  Google Scholar 

  • Scharfman, H. E., Goodman, J. H., and Sollas, A. L., 1999, Actions of brain-derived neurotrophic factor in slices from rats with spontaneous seizures and mossy fiber sprouting in the dentate gyrus. J Neurosci, 19, 5619.

    PubMed  CAS  Google Scholar 

  • Scharfman, H. E., Goodman, J. H., and Sollas, A. L., 2000, Granule-like neurons at the hilar/CA3 border after status epilepticus and their synchrony with area CA3 pyramidal cells: functional implications of seizure-induced neurogenesis. J Neurosci, 20, 6144.

    PubMed  CAS  Google Scholar 

  • Scharfman, H. E., Kunkel, D. D., and Schwartzkroin, P. A., 1990, Synaptic connections of dentate granule cells and hilar neurons: results of paired intracellular recordings and intracellular horseradish peroxidase injections. Neuroscience, 37, 693.

    Article  PubMed  CAS  Google Scholar 

  • Scharfman, H. E., Mercurio, T. C., Goodman, J. H., Wilson, M. A., and MacLusky, N. J., 2003, Hippocampal excitability increases during the estrous cycle in the rat: a potential role for brain-derived neurotrophic factor. J Neurosci., 23, 11641.

    PubMed  CAS  Google Scholar 

  • Scharfman, H. E. and Schwartzkroin, P. A., 1990, Consequences of prolonged afferent stimulation of the rat fascia dentata: epileptiform activity in area CA3 of hippocampus. Neuroscience, 35, 505.

    Article  PubMed  CAS  Google Scholar 

  • Scharfman, H. E., Smith, K. L., Goodman, J. H., and Sollas, A. L., 2001, Survival of dentate hilar mossy cells after pilocarpine-induced seizures and their synchronized burst discharges with area CA3 pyramidal cells. Neuroscience, 104, 741.

    Article  PubMed  CAS  Google Scholar 

  • Scharfman, H. E., Solas, A. L., Smith, K. L., Jackson, M. B., and Goodman, J. H., 2002b, Structural and functional asymmetry in the normal and epileptic rat dentate gyrus. J Comp Neurol., 454, 424.

    Article  PubMed  Google Scholar 

  • Schinder, A. F., Berninger, B., and Poo, M., 2000, Postsynaptic target specificity of neurotrophin-induced presynaptic potentiation. Neuron., 25, 151.

    Article  PubMed  CAS  Google Scholar 

  • Schratt, G. M., Nigh, E. A., Chen, W. G., Hu, L., and Greenberg, M. E., 2004, BDNF regulates the translation of a select group of mRNAs by a mammalian target of rapamycin-phosphatidylinositol 3-kinase-dependent pathway during neuronal development. J. Neurosci., 24, 7366.

    Article  PubMed  CAS  Google Scholar 

  • Singh, M., Meyer, E. M., and Simpkins, J. W., 1995, The effect of ovariectomy and estradiol replacement on brain-derived neurotrophic factor messenger ribonucleic acid expression in cortical and hippocampal brain regions of female Sprague-Dawley rats. Endocrinology, 136, 2320.

    Article  PubMed  CAS  Google Scholar 

  • Sloviter, R. S., 1992, Possible functional consequences of synaptic reorganization in the dentate gyrus of kainate-treated rats. Neurosci Lett., 137, 91.

    Article  PubMed  CAS  Google Scholar 

  • Smith, M. A., Makino, S., Kvetnansky, R., and Post, R. M., 1995, Stress and glucocorticoids affect the expression of brain-derived neurotrophic factor and neurotrophin-3 mRNAs in the hippocampus. J Neurosci., 15, 1768.

    PubMed  CAS  Google Scholar 

  • Sohrabji, F., Miranda, R. C., and Toran-Allerand, C. D., 1995, Identification of a putative estrogen response element in the gene encoding brain-derived neurotrophic factor. Proc Natl Acad Sci USA, 92, 11110.

    Article  PubMed  CAS  Google Scholar 

  • Sperk, G., Bellmann, R., Gruber, B., Greber, S., Marksteiner, J., Roder, C., and Rupp, E., 1996, Neuropeptide Y expression in animal models of temporal lobe epilepsy. Epilepsy Res Suppl., 12, 197.

    PubMed  CAS  Google Scholar 

  • Tanaka, T., Saito, H., and Matsuki, N., 1997, Inhibition of GABAA synaptic responses by brain-derived neurotrophic factor (BDNF) in rat hippocampus. J Neurosci, 17, 2959.

    PubMed  CAS  Google Scholar 

  • Tartaglia, N., Tyler, W. J., Neale, E., Pozzo-Miller, L., and Lu, B., 2001, Protein synthesis-dependent and-independent regulation of hippocampal synapses by brain-derived neurotrophic factor. J Biol Chem., 276, 37585.

    Article  PubMed  CAS  Google Scholar 

  • Tauck, D. L. and Nadler, J. V., 1985, Evidence of functional mossy fiber sprouting in hippocampal formation of kainic acid-treated rats. J Neurosci., 5, 1016.

    PubMed  CAS  Google Scholar 

  • Thompson, S. M. and Gahwiler, B. H., 1989, Activity-dependent disinhibition. I. Repetivitve stimulation reduces IPSP driving force and conductance in the hippocampus in vitro. J Neurophysiol., 61, 501.

    PubMed  CAS  Google Scholar 

  • Tongiorgi, E., Armellin, M., Giulianini, P. G., Bregola, G., Zucchini, S., Paradiso, B., Steward, O., Cattaneo, A., and Simonato, M., 2004, Brain-derived neurotrophic factor mRNA and protein are targeted to discrete dendritic laminas by events that trigger epileptogenesis. J Neurosci., 24, 6824.

    Article  CAS  Google Scholar 

  • Turski, W. A., Cavalheiro, E. A., Schwarz, M., Czuczwar, S. J., Kleinrok, Z., and Turski, L., 1983, Limbic seizures produced by pilocarpine in rats: behavioural, electroencephalographic and neuropathological study. Behav Brain Res., 9, 315.

    Article  PubMed  CAS  Google Scholar 

  • Tyler, W. J., Perrett, S. P., and Pozzo-Miller, L. D., 2002, The role of neurotrophins in neurotransmitter release. The Neuroscientist, 8, 524.

    Article  PubMed  CAS  Google Scholar 

  • Vicario-Abejon, C., Owens, D., McKay, R., and Segal, M., 2002, Role of neurotrophins in central synapse formation and stabilization. Nature Reviews Neurosci, 3, 965.

    Article  CAS  Google Scholar 

  • von Kitzing E., Jonas P., Sakmann B., 1994, 1994, Quantal analysis of excitatory postsynaptic currents at the hippocampal mossy fiber-CA3 pyramidal cell synapse. Adv Second Messenger Phosphoprotein Res. 29, 235.

    Google Scholar 

  • Wenzel, H. J., Woolley, C. S., Robbins, C. A., and Schwartzkroin, P. A., 2000, Kainic acid-induces mossy fiber sprouting and synapse formation in the dentate gyrus of rats. Hippocampus, 10, 244.

    Article  PubMed  CAS  Google Scholar 

  • Wong, R. K. and Watkins, D. J., 1982, Cellular factors influencing GABA response in hippocampal pyramidal cells. J Neurophysiol., 48, 938.

    PubMed  CAS  Google Scholar 

  • Xu, B., Michalski, B., Racine, R. J., and Fahnestock, M., 2004, The effects of brain-derived neurotrophic factor (BDNF) administration on kindling induction, Trk expression and seizure-related morphological changes. Neuroscience, 126, 521.

    Article  PubMed  CAS  Google Scholar 

  • Yan, Q., Rosenfeld, R. D., Matheson, C. R., Hawkins, N., Lopez, O. T., Bennett, L., and Welcher, A. A., 1997, Expression of brain-derived neurotrophic factor (BDNF) protein in the adult rat central nervous system. Neuroscience, 78, 431.

    Article  PubMed  CAS  Google Scholar 

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Scharfman, H.E. (2005). Brain-Derived Neurotrophic Factor (BDNF) and the Dentate Gyrus Mossy Fibers: Implications for Epilepsy. In: Stanton, P.K., Bramham, C., Scharfman, H.E. (eds) Synaptic Plasticity and Transsynaptic Signaling. Springer, Boston, MA. https://doi.org/10.1007/0-387-25443-9_13

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