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C-Reactive Protein as a Regulator of Autoimmune Disease

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Molecular Autoimmunity

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References

  • Agrawal, A., Shrive, A.K., Greenhough, T.J., and Volanakis, J.E. (2001). Topology and structure of the C1q-binding site on C-reactive protein. J. Immunol., 166, 3998–4004.

    CAS  PubMed  Google Scholar 

  • Ahmed, N., Thorley, R., Xia, D., Samols, D., and Webster, R.O. (1996). Transgenic mice expressing rabbit C-reactive protein exhibit diminished chemotactic factor-induced alveolitis. Am. J. Respir. Crit. Care Med., 153, 1141–1147.

    CAS  PubMed  Google Scholar 

  • Arend, W.P., Malyak, M., Guthridge, C.J., and Gabay, C. (1998). Interleukin-1 receptor antagonist: Role in biology. Annu. Rev. Immunol., 16, 27–55.

    Article  CAS  PubMed  Google Scholar 

  • Ballou, S.P. and Kushner, I. (1992). C-reactive protein and the acute phase response. Adv. Intern. Med., 37, 313–336.

    CAS  PubMed  Google Scholar 

  • Becker, G.J., Waldburger, M., Hughes, G.R., and Pepys, M.B. (1980). Value of serum C-reactive protein measurement in the investigation of fever in systemic lupus erythematosus. Ann. Rheum. Dis., 39, 50–52.

    CAS  PubMed  Google Scholar 

  • Berger, P., McConnell, J.P., Nunn, M., Kornman, KS., Sorrell, J., Stephenson, K., and Duff, G.W. (2002). C-reactive protein levels are influenced by common IL-1 gene variations. Cytokine, 17, 171–174.

    Article  CAS  PubMed  Google Scholar 

  • Bharadwaj, D., Mold, C., Markham, E., and Du Clos, T.W. (2001). Serum amyloid P component binds to Fcγ receptors and opsonizes particles for phagocytosis. J. Immunol., 166, 6735–6741.

    CAS  PubMed  Google Scholar 

  • Bharadwaj, D., Stein, M.P., Volzer, M., Mold, C., and Du Clos, T.W. (1999). The major receptor for C-reactive protein on leukocytes is Fcγ receptor II. J. Exp. Med., 190, 585–590.

    Article  CAS  PubMed  Google Scholar 

  • Bickerstaff, M.C., Botto, M., Hutchinson, W.L., Herbert, J., Tennent, G.A., Bybee, A., Mitchell, D.A., Cook, H.T., Butler, P.J., Walport, M.J., and Pepys, M.B. (1999). Serum amyloid P component controls chromatin degradation and prevents antinuclear autoimmunity. Nat. Med., 5, 694–697.

    CAS  PubMed  Google Scholar 

  • Bodman-Smith, K.B., Gregory, R.E., Harrison, P.T., and Raynes, J.G. (2004). FcγRIIa expression with FcγRI results in C-reactive protein-and IgG-mediated phagocytosis. J. Leukoc. Biol., 75, 1029–1035.

    Article  CAS  PubMed  Google Scholar 

  • Bodman-Smith, K.B., Melendez, A.J., Campbell, I., Harrison, P.T., Allen, J.M., and Raynes, J.G. (2002). C-reactive protein-mediated phagocytosis and phospholipase D signaling through the high-affinity receptor for immunoglobulin G (FcγRI). Immunology, 107, 252–260.

    Article  CAS  PubMed  Google Scholar 

  • Brull, D.J., Serrano, N., Zito, F., Jones, L., Montgomery, H.E., Rumley, A., Sharma, P., Lowe, G.D., World, M.J., Humphries, S.E., and Hingorani, A.D. (2003). Human CRP gene polymorphism influences CRP levels: Implications for the prediction and pathogenesis of coronary heart disease. Arterioscler. Thromb. Vasc. Biol., 23, 2063–2069.

    CAS  PubMed  Google Scholar 

  • Burlingame, R.W., Boey, M.L., Starkebaum, G., and Rubin, R.L. (1994). The central role of chromatin in autoimmune responses to histones and DNA in systemic lupus erythematosus. J. Clin. Invest., 94, 184–192.

    CAS  PubMed  Google Scholar 

  • Burlingame, R.W., Rubin, R.L., Balderas, R.S., and Theofilopoulos, A.N. (1993). Genesis and evolution of antichromatin autoantibodies in murine lupus implicates T-dependent immunization with self antigen. J. Clin. Invest., 91, 1687–1696.

    CAS  PubMed  Google Scholar 

  • Burlingame, R.W., Volzer, M.A., Harris, J., and Du Clos, T.W. (1996). The effect of acute phase proteins on clearance of chromatin from the circulation of normal mice. J. Immunol., 156, 4783–4788.

    CAS  PubMed  Google Scholar 

  • Carroll, M.C. (2000). A protective role for innate immunity in autoimmune disease. Clin. Immunol., 95, S30–S38.

    Article  CAS  PubMed  Google Scholar 

  • Casciola-Rosen, L.A., Anhalt, G., and Rosen, A. (1994). Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes. J. Exp. Med., 179, 1317–1330.

    Article  CAS  PubMed  Google Scholar 

  • Chi, M., Tridandapani, S., Zhong, W., Coggeshall, K.M., and Mortensen, R.F. (2002). C-reactive protein induces signaling through FcγRIIa on HL-60 granulocytes. J. Immunol., 168, 1413–1418.

    CAS  PubMed  Google Scholar 

  • Clynes, R., Dumitru, C., and Ravetch, J.V. (1998). Uncoupling of immune complex formation and kidney damage in autoimmune glomerulonephritis. Science, 279, 1052–1054.

    Article  CAS  PubMed  Google Scholar 

  • Crowell, R.E., Du Clos, T.W., Montoya, G., Heaphy, E., and Mold, C. (1991). C-reactive protein receptors on the human monocytic cell line U-937. Evidence for additional binding to Fc gamma RI. J. Immunol., 147, 3445–3451.

    CAS  PubMed  Google Scholar 

  • Du Clos, T.W. (1989). C-reactive protein reacts with the U1 small nuclear ribonucleoprotein. J. Immunol., 143, 2553–2559.

    PubMed  Google Scholar 

  • Du Clos, T.W. (1996). The interaction of C-reactive protein and serum amyloid P component with nuclear antigens. Mol. Biol. Rep., 23, 253–260.

    Article  PubMed  Google Scholar 

  • Du Clos, T.W. (2000). Function of C-reactive protein. Ann. Med., 32, 274–278.

    PubMed  Google Scholar 

  • Du Clos, T.W. and Mold, C. (2003). C-reactive protein: Structure, synthesis and function. In S.Y. Wong and G. Arsequell (eds), Immunobiology of Carbohydrates. Kluwer Academic/Plenum Publishers, New York. pp. 39–55.

    Google Scholar 

  • Du Clos, T.W., Mold, C., and Stump, R.F. (1990). Identification of a polypeptide sequence that mediates nuclear localization of the acute phase protein C-reactive protein. J. Immunol., 145, 3869–3875.

    PubMed  Google Scholar 

  • Du Clos, T.W., Zlock, L.T., Hicks, P.S., and Mold, C. (1994). Decreased autoantibody levels and enhanced survival of (NZB × NZW) F1 mice treated with C-reactive protein. Clin. Immunol. Immunopathol., 70, 22–27.

    PubMed  Google Scholar 

  • Familian, A., Zwart, B., Huisman, H.G., Rensink, I., Roem, D., Hordijk, P.L., Aarden, L.A., and Hack, C.E. (2001). Chromatin-independent binding of serum amyloid P component to apoptotic cells. J. Immunol., 167, 647–654.

    CAS  PubMed  Google Scholar 

  • Gabay, C., Roux-Lombard, P., de Moerloose, P., Dayer, J.M., Vischer, T., and Guerne, P.A. (1993). Absence of correlation between interleukin 6 and C-reactive protein blood levels in systemic lupus erythematosus compared with rheumatoid arthritis. J. Rheumatol., 20, 815–821.

    CAS  PubMed  Google Scholar 

  • Gerber, J.S. and Mosser, D.M. (2001). Reversing lipopolysaccharide toxicity by ligating the macrophage Fcγ receptors. J. Immunol., 166, 6861–6868.

    CAS  PubMed  Google Scholar 

  • Gershov, D., Kim, S., Brot, N., and Elkon, K.B. (2000). C-reactive protein binds to apoptotic cells, protects the cells from assembly of the terminal complement components, and sustains an antiinflammatory innate immune response: Implications for systemic autoimmunity. J. Exp. Med., 192, 1353–1363.

    Article  CAS  PubMed  Google Scholar 

  • Gitlin, J.D., Gitlin, J.I., and Gitlin, D. (1977). Localization of C-reactive protein in synovium of patients with rheumatoid arthritis. Arthritis Rheum., 20, 1491–1499.

    CAS  PubMed  Google Scholar 

  • Han, K.H., Hong, K.H., Park, J.H., Ko, J., Kang, D.H., Choi, K.J., Hong, M.K., Park, S.W., and Park, S.J. (2004). C-reactive protein promotes monocyte chemoattractant protein-1-mediated chemotaxis through upregulating CC chemokine receptor 2 expression in human monocytes. Circulation, 2566–2571.

    Google Scholar 

  • Heuertz, R.M., Dongyuan, X., Samols, D., and Webster, R.O. (1994). Inhibition of C5a des Arginduced neutrophil alveolitis in transgenic mice expressing C-reactive protein. Am. J. Physiol., 266, L649–L654.

    CAS  PubMed  Google Scholar 

  • Heuertz, R.M., Tricomi, S.M., Ezekieli, U.R., and Webster, R.O. (1999). C-reactive protein inhibits chemotactic peptide-induced p38 mitogen-activated protein kinase activity and human neutrophil movement. J. Biol. Chem., 275, 17968–17974.

    Google Scholar 

  • Hicks, P.S., Saunero-Nava, L., Du Clos, T.W., and Mold, C. (1992). Serum amyloid P component binds to histones and activates the classical complement pathway. J. Immunol., 149, 3689–3694.

    CAS  PubMed  Google Scholar 

  • Kushner, I. and Kaplan, M.H. (1961). Studies of acute phase protein. I. An immunohistochemical method for the localization of Cx-reactive protein in rabbits: Association with necrosis in inflammatory lesions. J. Exp. Med., 114, 961–973.

    Article  CAS  PubMed  Google Scholar 

  • Li, Y.P., Mold, C., and Du Clos, T.W. (1994). Sublytic complement attack exposes C-reactive protein binding sites on cell membranes. J. Immunol., 152, 2995–3005.

    CAS  PubMed  Google Scholar 

  • Marnell, L.L., Mold, C., Volzer, M.A., Burlingame, R.W., and Du Clos, T.W. (1995). C-reactive protein binds to Fc gamma RI in transfected COS cells. J. Immunol., 155, 2185–2193.

    CAS  PubMed  Google Scholar 

  • Mold, C., Baca, R., and Du Clos, T.W. (2002a). Serum amyloid P component and C-reactive protein opsonize apoptotic cells for phagocytosis through Fcγ receptors. J. Autoimmunity, 19, 147–154.

    Article  Google Scholar 

  • Mold, C., Gresham, H.D., and Du Clos, T.W. (2001). Serum amyloid P component and C-reactive protein mediate phagocytosis through murine FcγRs. J. Immunol., 166, 1200–1205.

    CAS  PubMed  Google Scholar 

  • Mold, C., Nakayama, S., Holzer, T.J., Gewurz, H., and Du Clos, T.W. (1981). C-reactive protein is protective against Streptococcus pneumoniae infection in mice. J. Exp. Med., 154, 1703–1708.

    Article  CAS  PubMed  Google Scholar 

  • Mold, C., Rodic-Polic, B., and Du Clos, T.W. (2002b). Protection from Streptococcus pneumoniae infection by C-reactive protein and natural antibody requires complement but not Fcγ receptors. J. Immunol., 168, 6375–6381.

    CAS  PubMed  Google Scholar 

  • Mold, C., Rodriguez, W., Rodic-Polic, B., and Du Clos, T.W. (2002c). C-reactive protein mediates protection from lipopolysaccharide through interactions with FcγR. J. Immunol., 169, 7019–7025.

    CAS  PubMed  Google Scholar 

  • Moore, K.W., Malefyt, R.D.W., Coffman, R.L., and O’Garra, A. (2001). Interleukin-10 and the Interleukin-10 receptor. Annu. Rev. Immunol., 19, 683–765.

    Article  CAS  PubMed  Google Scholar 

  • Mortensen, R.F. and Duszkiewicz, J.A. (1977). Mediation of CRP-dependent phagocytosis through mouse macrophage Fc-receptors. J. Immunol., 119, 1611–1616.

    CAS  PubMed  Google Scholar 

  • Narkates, A.J. and Volanakis, J.E. (1982). C-reactive protein binding specificities: Artificial and natural phospholipid bilayers. Ann. N Y Acad. Sci., 389, 172–181.

    CAS  PubMed  Google Scholar 

  • Paul, A., Ko, K.W., Li, L., Yechoor, V., McCrory, M.A., Szalai, A.J., and Chan, L. (2004). C-reactive protein accelerates the progression of atherosclerosis in apolipoprotein E-deficient mice. Circulation, 109, 647–655.

    Article  CAS  PubMed  Google Scholar 

  • Pepys, M.B., Baltz, M.L., Gomer, K., Davis, J.S., and Doenhoff, M. (1979). Serum amyloid P component is an acute phase reactant in mouse. Nature, 278, 259–261.

    Article  CAS  PubMed  Google Scholar 

  • Pepys, M.B., Booth, S.E., Tennent, G.A., Butler, P.J.G., and Williams, D.G. (1994). Binding of pentraxins to different nuclear structures: C-reactive protein binds to small nuclear ribonucleoprotein particles, serum amyloid P component binds to chromatin and nucleoli. Clin. Exp. Immunol., 97, 152–157.

    CAS  PubMed  Google Scholar 

  • Pepys, M.B., and Butler, P.J.G. (1987). Serum amyloid P component is the major calcium-dependent specific DNA binding protein of the serum. Biochem. Biophys. Res. Commun., 148, 308–313.

    Article  CAS  PubMed  Google Scholar 

  • Ravetch, J.V. and Bolland, S. (2001). IgG Fc receptors. Annu. Rev. Immunol., 19, 275–290.

    Article  CAS  PubMed  Google Scholar 

  • Ravetch, J.V. and Lanier, L.L. (2000). Immune inhibitory receptors. Science, 290, 84–89.

    Article  CAS  PubMed  Google Scholar 

  • Ridker, P.M. (2003). Clinical application of C-reactive protein for cardiovascular disease detection and prevention. Circulation, 107, 363–369.

    PubMed  Google Scholar 

  • Robey, F.A., Jones, K.D., Tanaka, T., and Liu, T.-Y. (1984). Binding of C-reactive protein to chromatin and nucleosome core particles. A possible physiological role of C-reactive protein. J. Biol. Chem., 259, 7311–7316.

    CAS  PubMed  Google Scholar 

  • Rodriguez, W., Mold, C., Kataranovski, M., Marnell, L., Hutt, J., and Du Clos, T.W. (2004). C-reactive protein reverses ongoing nephritis in autoimmune mice. Arthritis Rheum., 52, 642–650

    Google Scholar 

  • Russell, A.I., Cunninghame Graham, D.S., Shepherd, C., Roberton, C.A., Whittaker, J., Meeks, J., Powell, R.J., Isenberg, D.A., Walport, M.J., and Vyse, T.J. (2004). Polymorphism at the C-reactive protein locus influences gene expression and predisposes to systemic lupus erythematosus. Hum. Mol. Genet., 13, 137–147.

    CAS  PubMed  Google Scholar 

  • Soma, M., Tamaoki, T., Kawano, H., Ito, S., Sakamoto, M., Okada, Y., Ozaki, Y., Kanba, S., Hamada, Y., Ishihara, T., and Maeda, S. (2001). Mice lacking serum amyloid P component do not necessarily develop severe autoimmune disease. Biochem. Biophys. Res. Commun., 286, 200–205.

    Article  CAS  PubMed  Google Scholar 

  • Stein, M.P., Mold, C., and Du Clos, T.W. (2000). C-reactive protein binding to murine leukocytes requires Fcγ receptors. J. Immunol., 164, 1514–1520.

    CAS  PubMed  Google Scholar 

  • Sutterwala, F.S., Noel, G.J., Salgame, P., and Mosser, D.M. (1998). Reversal of proinflammatory responses by ligating the macrophage Fcγ receptor type I. J. Exp. Med., 188, 217–222.

    Article  CAS  PubMed  Google Scholar 

  • Szalai, A.J., McCrory, M.A., Cooper, G.S., Wu, J., and Kimberly, R.P. (2002b). Association between baseline levels of C-reactive protein (CRP) and a dinucleotide repeat polymorphism in the intron of the CRP gene. Genes Immun., 3, 14–19.

    Article  CAS  PubMed  Google Scholar 

  • Szalai, A.J., Nataf, S., Hu, X.-Z., and Barnum, S.R. (2002a). Experimental allergic encephalomyelitis is inhibited in transgenic mice expressing human C-reactive protein. J. Immunol., 168, 5792–5797.

    CAS  PubMed  Google Scholar 

  • Szalai, A.J., Weaver, C.T., McCrory, M.A., van Ginkel, F.W., Reiman, R.M., Kearney, J.F., Marion, T.N., and Volanakis, J.E. (2003). Delayed lupus onset in (NZB × NZW)F1 mice expressing a human C-reactive protein transgene. Arthritis Rheum., 48, 1602–1611.

    Article  CAS  PubMed  Google Scholar 

  • Tarzi, R.M., Davies, K.A., Claassens, J.W., Verbeek, J.S., Walport, M.J., and Cook, H.T. (2003). Both Fcγ receptor I and Fcγ receptor III mediate disease in accelerated nephrotoxic nephritis. Am. J. Pathol., 162, 1677–1683.

    CAS  PubMed  Google Scholar 

  • Tarzi, R.M., Davies, K.A., Robson, M.G., Fossati-Jimack, L., Saito, T., Walport, M.J., and Cook, H.T. (2002). Nephrotoxic nephritis is mediated by Fcγ receptors on circulating leukocytes and not intrinsic renal cells. Kidney Int., 62, 2087–2096.

    Article  CAS  PubMed  Google Scholar 

  • Tebo, J.M. and Mortensen, R.F. (1990). Characterization and isolation of a C-reactive protein receptor from the human monocytic cell line U-937. J. Immunol., 144, 231–238.

    CAS  PubMed  Google Scholar 

  • ter Borg, E.J., Horst, G., Limburg, P.C., van Rijswijk, M.H., and Kallenberg, C.G. (1990). C-reactive protein levels during disease exacerbations and infections in systemic lupus erythematosus: A prospective longitudinal study. J. Rheumatol., 17, 1642–1648.

    PubMed  Google Scholar 

  • Theofilopoulos, A.N. and Dixon, F.J. (1985). Murine models of systemic lupus erythematosus. Adv. Immunol., 37, 269–391.

    CAS  PubMed  Google Scholar 

  • Thompson, D., Pepys, M.B., and Wood, S.P. (1999). The physiological structure of human C-reactive protein and its complex with phosphocholine. Structure, 7, 169–177.

    Article  CAS  PubMed  Google Scholar 

  • Tilg, H., Vannier, E., Vachino, G., Dinarello, C.A., and Mier, J.W. (1993). Antiinflammatory properties of hepatic acute phase proteins: Preferential induction of Interleukin 1 (IL-1) receptor antagonist over IL-1b synthesis by human peripheral blood mononuclear cells. J. Exp. Med., 178, 1629–1636.

    Article  CAS  PubMed  Google Scholar 

  • Tillett, W.S. and Francis, T., Jr. (1930). Serological reactions in pneumonia with a non-protein fraction of pneumococcus. J. Exp. Med., 52, 561–571.

    CAS  Google Scholar 

  • Vickers, M.A., Green, F.R., Terry, C., Mayosi, B.M., Julier, C., Lathrop, M., Ratcliffe, P.J., Watkins, H.C., and Keavney, B. (2002). Genotype at a promoter polymorphism of the interleukin-6 gene is associated with baseline levels of plasma C-reactive protein. Cardiovasc. Res., 53, 1029–1034.

    Article  CAS  PubMed  Google Scholar 

  • Volanakis, J.E. (2001). Human C-reactive protein: Expression, structure, and function. Mol. Immunol., 38, 189–197.

    Article  CAS  PubMed  Google Scholar 

  • Volanakis, J.E. and Kaplan, M.H. (1971). Specificity of C-reactive protein for choline phosphate residues of pneumococcal C-polysaccharide. Proc. Soc. Exp. Biol. Med., 136, 612–614.

    CAS  PubMed  Google Scholar 

  • Walport, M.J. (2000). Lupus, DNase and defective disposal of cellular debris. Nat. Genet., 25, 135–136.

    Article  CAS  PubMed  Google Scholar 

  • Whitehead, A.S., Zahedi, K., Rits, M., Mortensen, R.F., and Lelias, J.M. (1990). Mouse C-reactive protein generation of cDNA clones, structural analysis, and induction of mRNA during inflammation. Biochem. J., 266, 283–290.

    CAS  PubMed  Google Scholar 

  • Xia, D. and Samols, D. (1997). Transgenic mice expressing rabbit C-reactive protein are resistant to endotoxemia. Proc. Natl. Acad. Sci. USA., 94, 2575–2580.

    CAS  PubMed  Google Scholar 

  • Zahedi, K., Tebo, J.M., Siripont, J., Klimo, G.F., and Mortensen, R.F. (1989). Binding of human C-reactive protein to mouse macrophages is mediated by distinct receptors. J. Immunol., 142, 2384–2392.

    CAS  PubMed  Google Scholar 

  • Zee, R.Y. and Ridker, P.M. (2002). Polymorphism in the human C-reactive protein (CRP) gene, plasma concentrations of CRP, and the risk of future arterial thrombosis. Atherosclerosis, 162, 217–219.

    Article  CAS  PubMed  Google Scholar 

  • Zein, N., Ganuza, C., and Kushner, I. (1979). Significance of serum C-reactive protein elevation in patients with systemic lupus erythematosus. Arthritis Rheum., 22, 7–12.

    CAS  PubMed  Google Scholar 

  • Zwaka, T.P., Hombach, V., and Torzewski, J. (2001). C-reactive protein-mediated low density lipoprotein uptake by macrophages: Implications for atherosclerosis. Circulation, 103, 1194–1197.

    CAS  PubMed  Google Scholar 

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Du Clos, T.W., Mold, C. (2005). C-Reactive Protein as a Regulator of Autoimmune Disease. In: Zouali, M. (eds) Molecular Autoimmunity. Springer, Boston, MA. https://doi.org/10.1007/0-387-24534-0_3

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