7. Concluding Remarks
The discovery that TLR9 can promote the production of autoantibodies by synergistically activating B cells in conjunction with BCR raises the intriguing possibility that self-DNA is immunostimulatory in a T cell-independent manner. Furthermore, TLRs can no longer be regarded as recognition systems in the innate immune system that shows exclusive selectivity for pathogen-associated molecules. TLR9 compromises the capacity for absolute distinction between self and nonself. Our current molecular appreciation of the TLR9 signaling pathway provides hope for therapeutic manipulation and the design of novel strategies for treating autoimmune diseases.
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Moynagh, P.N. (2005). Toll-like Receptor 9 and Autoimmunity. In: Zouali, M. (eds) Molecular Autoimmunity. Springer, Boston, MA. https://doi.org/10.1007/0-387-24534-0_2
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