Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
M. E. Bruce, R. G. Will, J. W. Ironside, I. McConnell, D. Drummond, A. Suttie, L. McCardle, A. Chree, J. Hope, C. Birkett, S. Cousens, H. Fraser and C. J. Bostock, Transmissions to mice indicate that ‘new variant’ CJD is caused by the BSE agent. Nature 389, 498–501. (1997).
M. D. Spencer, R. S. Knight, and R. G. Will, First hundred cases of variant Creutzfeldt-Jakob disease: retrospective case note review of early psychiatric and neurological features. Bmj 324, 1479–1482. (2002).
I. Zerr and S. Poser, Clinical diagnosis and differential diagnosis of CJD and vCJD. With special emphasis on laboratory tests. Apmis 110, 88–98. (2002).
A. Otto, I. Zerr, M. Lantsch, K. Weidehaas, C. Riedemann and S. Poser, Akinetic mutism as a classification criterion for the diagnosis of Creutzfeldt-Jakob disease. J Neurol Neurosurg Psychiatry 64, 524–528. (1998).
M. E. Bruce, I. McConnell, H. Fraser and A. G. Dickinson, The disease characteristics of different strains of scrapie in Sinc congenic mouse lines: implications for the nature of the agent and host control of pathogenesis. J Gen Virol 72, 595–603. (1991).
M. Jeffrey, W. G. Halliday, J. Bell, A. R. Johnston, N. K. MacLeod, C. Ingham, A. R. Sayers, D. A. Brown and J. R. Fraser, Synapse loss associated with abnormal PrP precedes neuronal degeneration in the scrapie-infected murine hippocampus. Neuropathol Appl Neurobiol 26, 41–54. (2000).
S. Betmouni, R. M. J. Deacon, J. N. P. Rawlins and V. H. Perry, Behavioural consequences of prion disease targeted to the hippocampus in a mouse model of scrapie. Psychobiology 27(1), 63–71 (1999).
R. M. Deacon, J. M. Raley, V. H. Perry and J. N. Rawlins, Burrowing into prion disease. Neuroreport 12, 2053–2057. (2001).
K. Guenther, R. M. Deacon, V. H. Perry and J. N. Rawlins, Early behavioural changes in scrapie-affected mice and the influence of dapsone. Eur J Neurosci 14, 401–409. (2001).
C. Cunningham, R. Deacon, H. Wells, D. Boche, S. Waters, C. P. Diniz, H. Scott, J. N. Rawlins and V. H. Perry, Synaptic changes characterize early behavioural changes inthe ME7 modelof murine prion disease. Eur. J. Neurosci. 17, 2147–2155 (2003).
C. J. Gordon, P. Becker and J. S. AIi, Behavioral thermoregulatory responses of single-and group-housed mice. Physiol Behav 65, 255–262. (1998).
J. P. Konsman, P. Parnet, and R. Dantzer, Cytokine-induced sickness behaviour: mechanisms and implications. Trends Neurosci 25, 154–159. (2002).
A. Aubert, G. Goodall, R. Dantzer and G. Gheusi, Differential effects of lipopolysaccharide on pup retrieving and nest building in lactating mice. Brain Behav Immun 11, 107–118. (1997).
G. W. Outram, Changes in drinking and feeding habits of mice with experimental scrapie. J Comp Pathol 82, 415–427. (1972).
A. J. Suckling, S. Bateman, C. B. Waldron, H. E. Webb and R. H. Kimberlin, Motor activity changes in scrapie-affected mice. Br J Exp Pathol 57, 742–746 (1976).
G. DeH’Omo, E. Vannoni, A. L. Vyssotski, M. A. Di Bari, R. Nonno, U. Agrimi and H. P. Lipp, Early behavioural changes in mice infected with BSE and scrapie: automated home cage monitoring reveals prion strain differences. Eur J Neurosci 16, 735–742. (2002).
R. Yirmiya, Endotoxin produces a depressive-like episode in rats. Brain Res 711, 163–174. (1996).
T. Borowski, L. Kokkinidis, Z. Merali, and H. Anisman, Lipopolysaccharide, central in vivo biogenicamine variations, and anhedonia. Neuroreport 9, 3797–3802. (1998).
G. W. Outram, H. Fraser and D. T. Wilson, Scrapie in mice. Some effects on the brain lesion profile of ME7 agent due to genotype of donor, route of injection and genotype of recipient. J Comp Pathol 83, 19–28. (1973).
R. I. Carp, Y. S. Kim, and S. M. Callahan, Scrapie-induced alterations in glucose tolerance in mice. J Gen Virol 70, 827–835. (1989).
G. W. Kreutzberg, Microglia: a sensor for pathological events in the CNS. Trends Neurosci 19, 312–318. (1996).
A. W. Hetherington, and S. W. Ranson,. The spontaneous activity and food intake of rats with hypothalamic lesions. Am J Physiol 136, 609–617 (1942).
R. M. Deacon, A. Croucher and J. N. Rawlins, Hippocampal cytotoxic lesion effects on species-typical behaviours in mice. Behav Brain Res 132, 203–213. (2002).
R. C. Bolles and M. S. Fanselow, A perceptual-defensive recuperative model of fear and pain. Behav Brain Sci 3, 291–323 (1980).
D. T. Walsh, S. Betmouni and V. H. Perry, Absenceof detectable IL-1beta production in murine prion disease: a model of chronic neurodegeneration. J Neuropathol Exp Neurol 60, 173–182. (2001).
C. Cunningham, D. Boche and V. H. Perry, Transforming growth factor betai, the dominant cytokine in murine prion disease: influence on inflammatory cytokine synthesis and alteration of vascular extracellular matrix. Neuropathol Appl Neurobiol 28, 107–119. (2002).
T. Cartmell, G. N. Luheshi and N. J. Rothwell, Brain sites of action of endogenous interleukin-1 in the febrile response to localized inflammation in the rat. J Physiol 518, 585–594. (1999).
R. M. J. Deacon, and J. N. P Rawlins, Hippocampal lesions, species-typical behaviours and anxiety in mice. Behav Brain Res 156, 241–249 (2005).
B. Reisberg, S. Finkel, J. Overall, N. Schmidt-Gollas, S. Kanowski, H. Lehfeld, F. Hulla, S. G. Sclan, H. U. Wilms, K. Heininger, I. Hindmarch, M. Stemmler, L. Poon, A. Kluger, C. Cooler, M. Bergener, L. Hugonot-Diener, P. H. Robert, S. Antipolis and H. Erzigkeit, The Alzheimer’s disease activities of daily living international scale (ADL-IS). Int Psychogeriatr, 13 163–181. (2001).
R. Nitrini, L. S. Teixeira da Silva, S. Rosemberg, P. Caramelli, P. E. Carrilho, P. lughetti, M. R. Passos-Bueno, M. Zatz, S. Albrecht and A. LeBlanc, Prion disease resembling frontotemporal dementia and parkinsonism linked to chromosome 17. Arq Neuropsiquiatr 59, 161–164. (2001).
S. E. Glickman and B. J. Morrison, Some behavioural and neural correlates of predation susceptibility in mice. Commun Behav Biol A 4, 261–267 (1969).
C. Masullo and G. Macchi, Resistance of the hippocampus in Creutzfeldt-Jakob disease. Clin Neuropathol 16, 37–14. (1997).
H. Mizusawa, A. Hirano and J. F. Llena, Involvement of hippocampus in Creutzfeldt-Jakob disease. J Neurol Sci 82, 13–26. (1987).
M. A. Poon, S. Stuckey and E. Storey, MRI evidence of cerebellar and hippocampal involvement in Creutzfeldt-Jakob disease. Neuroradiology 43, 746–749. (2001).
D. McFarland and J. Hotchin, Early behavioral abnormalities in mice due to scrapie virus encephalopathy. Biol Psychiatry 15, 37–44 (1980).
I. Tobler, T. Deboer and M. Fischer, Sleep and sleep regulation in normal and prion protein-deficient mice. J Neurosci 17, 1869–1879. (1997).
E. Choleris, A. W. Thomas, M. Kavaliers and F. S. Prato, A detailed ethological analysis of the mouse open field test: effects of diazepam, chlordiazepoxide and an extremely low frequency pulsed magnetic field. Neurosci Biobehav Rev 25, 235–260. (2001).
A. J. Hunter, M. P. Caulfield and R. H. Kimberlin, Learning ability of mice infected with differentstrains of scrapie. Physiol Behav 36, 1089–1092. (1986).
S. R. Bareggi, D. Braida, M. Gervasoni, G. Carcassola, C. Pollera, C. Verzoni, M. Sala and C. Vergerio, Neurochemical and behavioural modifications induced by scrapie infection in golden hamsters. Brain Res 984, 237–241. (2003).
A. M. Lysons and S. J. Woollard, Spatial reversal learning in preclinical scrapie-inoculated mice. Neuroreport, 7 1087–1091 (1996).
M. Zeidler, R. J. Sellar, D. A. Collie, R. Knight, G. Stewart, M. A. Macleod, J. W. Ironside, S. Cousens, A. C. Colchester, D. M. Hadley, R. G. Will and A. F. Colchester, The pulvinarsign on magnetic resonance imaging in variant Creutzfeldt-Jakob disease. Lancet 355, 1412–1418. (2000).
D. Brown, P. Belichenko, J. Sales, M. Jeffrey and J. R. Fraser, Early loss of dendritic spines in murine scrapie revealed by confocal analysis. Neuroreport 12, 179–183. (2001).
P. V. Belichenko, D. Brown, M. Jeffrey and J. R. Fraser, Dendritic and synaptic alterations of hippocampal pyramidal neurones in scrapie-infected mice. Neuropathol Appl Neurobiol 26, 143–149. (2000).
M. Jeffrey, C. M. Goodsir, M. E. Bruce, P. A. McBride and J. R. Fraser, In vivo toxicity of prion protein in murine scrapie: ultrastructural and immunogold studies. Neuropathol Appl Neurobiol 23, 93–101. (1997).
H. Fraser and A. G. Dickinson, Distribution of experimentally induced scrapie lesions inthebrain. Nature 216, 1310–1311 (1967).
R. M. Ridley and H. F. Baker, To what extent is strain variation evidence for an independent genome in the agent of the transmissible spongiform encephalopathies? Neurodegeneration 5, 219–231. (1996).
C. Cunningham, R. Deacon, K. Chan, D. Boche, J. N. P. Rawlins and V. H. Perry, Neuropathologically distinct strains give rise to similar temporal profiles of behavioural impairments. Neurobiol. Dis. 18, 258–269 (2005).
J. I. Kim, W. K. Ju, J. H. Choi, E. Choi, R. I. Carp, H. M. Wisniewski and Y. S. Kim, Expression of cytokine genes and increased nuclear factor-kappa B activity in the brains of scrapie-infected mice. Brain Res Mol Brain Res 73, 17–27. (1999).
M. A. Macleod, G. E. Stewart, M. Zeidler, R. Will and R. Knight, Sensory features of variant Creutzfeldt-Jakob disease. J Neurol 249, 706–711. (2002).
J. D. Schmahmann, Vascular syndromes of the thalamus. Stroke 34, 2264–2278. Epub 2003 Aug 2221. (2003).
H. Urbach, J. Klisch, H. K. Wolf, D. Brechtelsbauer, S. Gass and L. Solymosi, MRI in sporadic Creutzfeldt-Jakob disease: correlation with clinical and neuropathological data. Neuroradiology 40, 65–70. (1998).
B. Canciani, M. G. Bruzzone and T. Awan, Neuropathological correlatesof magnetic resonance abnormalities in experimental prion disease. J Neuropathol Exp Neurol 58, 560 (1999).
H. J. Tschampa, J. W. Herms, W. J. Schulz-Schaeffer, B. Maruschak, O. Windl, U. Jastrow, I. Zerr, B. J. Steinhoff, S. Poser and H. A. Kretzschmar, Clinical findings in sporadic Creutzfeldt-Jakob disease correlate with thalamic pathology. Brain 125, 2558–2566. (2002).
H. J. Tschampa, P. Murtz, S. Flacke, S. Paus, H. H. Schild and H. Urbach, Thalamic involvement in sporadic Creutzfeldt-Jakob disease: a diffusion-weighted MR imaging study. AJNR Am J Neuroradiol 24, 908–915. (2003).
E. Lugaresi, I. Tobler, P. Gambetti and P. Montagna, The pathophysiology of fatal familial insomnia. Brain Pathol 8, 521–526. (1998).
G. Macchi, G. Rossi, A. L. Abbamondi, G. Giaccone, D. Mancia, F. Tagliavini and O. Bugiani, Diffuse thalamic degeneration in fatal familial insomnia. A morphometric study. Brain Res 771, 154–158. (1997).
M. A. Klein, P. S. Kaeser, P. Schwarz, H. Weyd, I. Xenarios, R. M. Zinkernagel, M. C. Carroll, J. S. Verbeek, M. Botto, M. J. Walport, H. Molina, U. Kalinke, H. Acha-Orbea and A. Aguzzi, Complement facilitates early prion pathogenesis. Nat Med 7, 488–192. (2001).
M. Burwinkel, A. Schwarz, C. Riemer, J. Schultz, F. Van Landeghem and M. Baier, Rapid disease development in scrapie-infected mice deficient for CD40 ligand. EMBO Rep 8, 8 (2004).
L. Manuelidis, W. Fritch and I. Zaitsev, Dapsone to delay symptoms in Creutzfeldt-Jakob disease. Lancet 352, 456. (1998).
S. Supattapone, H. O. Nguyen, F. E. Cohen, S. B. Prusiner and M. R. Scott, Elimination of prions by branched polyamines and implications fortherapeutics. Proc Natl Acad Sci USA 96, 14529–14534. (1999).
A. R. White, P. Enever, M. Tayebi, R. Mushens, J. Linehan, S. Brandner, S. Anstee, J. Collinge and S. Hawke, Monoclonal antibodies inhibit prion replication and delay the development of prion disease. Nature 422, 80–83. (2003).
V. Perrier, J. Solassol, C. Crozet, Y. Frobert, C. Mourton-Gilles, J. Grassi and S. Lehmann, Anti-PrP antibodies block PrPSc replication in prion-infected cell cultures by accelerating PrPC degradation. J Neurochem 89, 454–163. (2004).
S. A. Priola, A. Raines and W. S. Caughey, Porphyrin and phthalocyanine antiscrapie compounds. Science 287, 1503–1506. (2000).
M. W. Head, C. F. Farquhar, N. A. Mabbott and J. R. Fraser, The transmissible spongiform encephalopathies: pathogenic mechanisms and strategies for therapeutic intervention. Expert Opin Ther Targets 5, 569–585. (2001).
G. Mallucci, A. Dickinson, J. Linehan, P. C. Klohn, S. Brandner and J. Collinge, Depleting neuronal PrP in prion infection prevents disease and reverses spongiosis. Science 302, 871–874. (2003).
R. H. Kimberlin, S. Cole and C. A. Walker, Pathogenesis of scrapie is faster when infection is intraspinal instead of intracerebral. Microb Pathog 2, 405–415. (1987).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2005 Springer Science+Business Media, Inc.
About this chapter
Cite this chapter
Cunningham, C. (2005). Mouse Behavioural Studies and What They Can Teach Us about Prion Diseases. In: Brown, D.R. (eds) Neurodegeneration and Prion Disease. Springer, Boston, MA. https://doi.org/10.1007/0-387-23923-5_5
Download citation
DOI: https://doi.org/10.1007/0-387-23923-5_5
Publisher Name: Springer, Boston, MA
Print ISBN: 978-0-387-23922-4
Online ISBN: 978-0-387-23923-1
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)