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c-Myc Deregulation Promotes a Complex Network of Genomic Instability

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Hormonal Carcinogenesis IV

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Conclusions

c-Myc is a versatile protein that has many different functions. With respect to genomic instability, it affects many endpoints that include gene amplification, translocation, deletions, insertions, long-range rearrangements, DNA breakage, and point mutations. This overall promotion of genomic instability suggests that c-Myc may have a central role in destabilizing the genome. We propose that c-Myc is a structural modifier of the genome and an important initiator and progressor molecule in neoplastic transformation.

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Authors and Affiliations

  1. Manitoba Institute of Cell Biology, CancerCare Manitoba, The University of Manitoba, Winnipeg, MB, Canada

    Sabine Mai

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  1. Sabine Mai
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  2. Amanda Guffei
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  3. Thierry Fest
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  4. J. Frederic Mushinski
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Editors and Affiliations

  1. Division of Etiology and Prevention of Hormonal Cancers, The University of Kansas Medical Center, 3901 Rainbow Boulevard, 2010 Breidenthal, Kansas City, KS, 66160-7417

    Jonathan J. Li (Profesor of Pharmacology, Toxicology and Therapeutics and Director) & Sara A. Li (Associate Research Professor of Pharmacology, Toxicology and Therapeutics) (Profesor of Pharmacology, Toxicology and Therapeutics and Director) &  (Associate Research Professor of Pharmacology, Toxicology and Therapeutics)

  2. Departmento de Patologia, Facultad de Medicina y Odontologia, Camino de Vera s/n, Valencia, 46071, Spain

    Antonio Llombart-Bosch (Director) (Director)

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Mai, S., Guffei, A., Fest, T., Mushinski, J.F. (2005). c-Myc Deregulation Promotes a Complex Network of Genomic Instability. In: Li, J.J., Li, S.A., Llombart-Bosch, A. (eds) Hormonal Carcinogenesis IV. Springer, Boston, MA. https://doi.org/10.1007/0-387-23761-5_7

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  • DOI: https://doi.org/10.1007/0-387-23761-5_7

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-387-23783-1

  • Online ISBN: 978-0-387-23761-9

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