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Chlamydia pneumoniae Infection and Diseases: Immunity to Chlamydia pneumoniae

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Chlamydia pneumoniae Infection and Disease

Part of the book series: Infectious Agents and Pathogenesis ((IAPA))

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Conclusion

C. pneumoniae has excited considerable attention during the last decade, not only as a respiratory pathogen but because of its association with a number of acute and chronic diseases, including atherosclerosis. The true linkage and causality of C. pneumoniae infection in the development of chronic manifestations remain puzzling. Efficient activation of type 1 T cell responses and secretion of IFN- γ mediates immune defense and provides improved recovery from reinfection. However, the factors that expose some individuals to impaired clearance of Chlamydia or drive immune responses to pathogenic ones are not known. The role of host genetic background, HLA molecules and cytokine gene polymorphism, environmental and epidemiological factors, mixed infections, and species or dose of the infecting agent probably all interact in a final balance of the immune defense mechanisms. A better understanding of the immunoregulatory processes during chlamydial infections in humans is necessary to furnish a novel immunotherapeutic strategy for treatment of acute C. pneumoniae infection and thereby to prevent development of disease manifestations that are associated with chronic or repeated infections. The understanding is facilitated by answering to the question whether the susceptibility for repeated infections is due to impaired type 1 response or activation of type 2 responses. The impact of primary host cells into developing immunity is a question of major importance and should be studied in humans.

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References

  1. Kuo, C.-C., Jackson, L. A., Campbell, L. A., and Grayston, J. T., 1995, Chlamydia pneumoniae (TWAR), Clin. Microbiol. Rev. 8:451.

    CAS  PubMed  Google Scholar 

  2. Grayston, J. T., 2002, Background and current knowledge of Chlamydia pneumoniae and atherosclerosis, J. Infect. Dis. 181:S402.

    Google Scholar 

  3. Coombes, B. K., and Mahony, J. B., 2001, cDNA array analysis of altered gene expression in human endothelial cells in response to Chlamydia pneumoniae infection, Infect. Immun. 69:1420.

    Article  CAS  PubMed  Google Scholar 

  4. Rasmussen, S.J., Eckmann, L., Quayle, A.J., Shen, L., Zhang, Y. X., Anderson, D.J., Fierer, J., Stephens, R. S., and Kagnoff, M. F., 1997, Secretion of proinflammatory cytokines by epithelial cells in response to Chlamydia infection suggests a central role for epithelial cells in chlamydial pathogenesis, J. Clin. Invest. 99:77.

    CAS  PubMed  Google Scholar 

  5. Jahn, H. U., Krull, M., Wuppermann, F. N., Klucken, A. C., Rosseau, S., Seybold, J., Hegemann, J. H., Jantos, C. A., and Suttorp, N., 2000, Infection and activation of airway epithelial cells by Chlamydia pneumoniae, J. Infect. Dis. 182:1678.

    Article  CAS  PubMed  Google Scholar 

  6. Molestina, R. E., Miller, R. D., Ramirez, J. A., and Summersgill, J. T., 1999, Infection of human endothelial cells with Chlamydia pneumoniae stimulates transendothelial migration of neutrophils and monocytes, Infect. Immun. 67:1323.

    CAS  PubMed  Google Scholar 

  7. Yang, J., Hooper, W. C., Phillips, D. J., Tondella, M. L., and Talkington, D. F., 2003, Induction of proinflammatory cytokines in human lung epithelial cells during Chlamydia pneumoniae infection, Infect. Immun. 71:614.

    CAS  PubMed  Google Scholar 

  8. Yang, Z. P., Kuo, C. C., and Grayston, J. T., 1993, A mouse model of Chlamydia pneumoniae strain TWAR pneumonitis, Infect. Immun. 61:2037.

    CAS  PubMed  Google Scholar 

  9. Yang, Z. P., Cummings, P. K., Patton, D. L., and Kuo, C. C., 1994, Ultrastructural lung pathology of experimental Chlamydia pneumoniae pneumonitis in mice, J. Infect. Dis. 170:464.

    CAS  PubMed  Google Scholar 

  10. Lipscomb, M. F., Bice, D. E., Lyons, C. R., Schuyler, M. R., and Wilkes, D., 1995, The regulation of pulmonary immunity, Adv. Immunol. 59:369.

    CAS  PubMed  Google Scholar 

  11. Prebeck, S., Kirschning, C., Durr, S., da Costa, C., Donath, B., Brand, K., Redecke, V., Wagner, H., and Miethke, T., 2001, Predominant role of toll-like receptor 2 versus 4 in Chlamydia pneumoniae-induced activation of dendritic cells, J. Immunol. 167:3316.

    CAS  PubMed  Google Scholar 

  12. Nakajo, M. N., Roblin, P. M., Hammerschlag, M. R., Smith, P., and Nowakowski, M., 1990, Chlamydicidal activity of human alveolar macrophages, Infect. Immun. 58:3640.

    CAS  PubMed  Google Scholar 

  13. Redecke, V., Dalhoff, K., Bohnet, S., Braun, J., and Maass, M., 1998, Interaction of Chlamydia pneumoniae and human alveolar macrophages: Infection and inflammatory response, Am. J. Resp. Cell. Mol. Biol. 19:721.

    CAS  Google Scholar 

  14. Hackstadt, T., Fischer, E. R., Scidmore, M. A., Rockey, D. D., and Heinzen, R. A., 1997, Origins and functions of the chlamydial inclusion [Review] [46 refs], Trends Microbiol. 5:288.

    CAS  PubMed  Google Scholar 

  15. Al-Younes, H. M., Rudel, T., and Meyer, T. F., 1999, Characterization and intracellular trafficking pattern of vacuoles containing Chlamydia pneumoniae in human epithelial cells, Cell Microbiol. 1:237.

    Article  CAS  PubMed  Google Scholar 

  16. Hackstadt, T., 2000, Redirection of host vesicle trafficking pathways by intracellular parasites, Traffic 1:93.

    Article  CAS  PubMed  Google Scholar 

  17. Scidmore, M. A., Fischer, E. R., and Hackstadt, T., 2003, Restricted fusion of Chlamydia trachomatis vesicles with endocytic compartments during the initial stages of infection, Infect. Immun. 71:973.

    Article  CAS  PubMed  Google Scholar 

  18. Gaydos, C. A., Summersgill, J. T., Sahney, N. N., Ramirez, J. A., and Quinn, T. C., 1996, Replication of Chlamydia pneumoniae in vitro in human macrophages, endothelial cells, and aortic artery smooth muscle cells, Infect. Immun. 64:1614.

    CAS  PubMed  Google Scholar 

  19. Kaukoranta-Tolvanen, S.-S. E., Teppo, A.-M., Laitinen, K., Saikku, P., Linnavuori, K., and Leinonen, M., 1996, Growth of Chlamydia pneumoniae in cultured human peripheral blood mononuclear cells and induction of a cytokine response, Microb. Pathog. 21:215.

    CAS  PubMed  Google Scholar 

  20. Airenne, S., Surcel, H. M., Alakärppä, H. Laitinen, K., Paavonen, J., Saikku, P., and Laurila, A., 1999, Chlamydia pneumoniae infection in human monocytes, Infect. Immun. 67:1445.

    CAS  PubMed  Google Scholar 

  21. Kuo Cc, C. C., Puolakkainen, M., Lin, T. M., Witte, M., and Campbell, L. A., 2002, Mannose-receptor positive and negative mouse macrophages differ in their susceptibility to infection by Chlamydia species, Microb. Pathog. 32:43.

    PubMed  Google Scholar 

  22. Moazed, T. C., Kuo, C. C., Grayston, J. T., and Campbell, L. A., 1998, Evidence of systemic dissemination of Chlamydia pneumoniae via macrophages in the mouse, J. Infect. Dis. 177:1322.

    CAS  PubMed  Google Scholar 

  23. Yang, Z. P., Kuo, C. C., and Grayston, J. T., 1995, Systemic dissemination of Chlamydia pneumoniae following intranasal inoculation in mice, J. Infect. Dis. 171:736.

    CAS  PubMed  Google Scholar 

  24. Kaukoranta-Tolvanen, S. S., Laurila, A. L., Saikku, P., Leinonen, M., Liesirova, L., and Laitinen, K., 1993, Experimental infection of Chlamydia pneumoniae in mice, Microb. Pathog. 15:293.

    CAS  PubMed  Google Scholar 

  25. Penttilä, J. M., Anttila, M., Puolakkainen, M., Laurila, A., Varkila, K., Sarvas, M., Mäkelä, P. H., and Rautonen, N., 1998, Local immune responses to Chlamydia pneumoniae in the lungs of BALB/c mice during primary infection and reinfection, Infect. Immun. 66:5113.

    PubMed  Google Scholar 

  26. Rottenberg, M. E., Gigliotti Rothfuchs, A. C., Gigliotti, D., Svanholm, C., Bandholtz, L., and Wigzell, H., 1999, Role of innate and adaptive immunity in the outcome of primary infection with Chlamydia pneumoniae, as analyzed in genetically modified mice, J. Immunol. 162:2829.

    CAS  PubMed  Google Scholar 

  27. Erkkilä, L., Laitinen, K., Laurila, A., Saikku, P., and Leinonen, M., 2002, Experimental Chlamydia pneumoniae infection in NIH/S mice: Effect of reinoculation with chlamydial or cell preparation on culture, PCR and histological findings of lung tissue, Vaccine 20:2318.

    PubMed  Google Scholar 

  28. Moazed, T. C., Kuo, C., Grayston, J. T., and Campbell, L. A., 1997, Murine models of Chlamydia pneumoniae infection and atherosclerosis, J. Infect. Dis. 175:883.

    CAS  PubMed  Google Scholar 

  29. Lin, T. M., Campbell, L. A., Rosenfeld, M. E., and Kuo, C. C., 2000, Monocyte-endothelial cell coculture enhances infection of endothelial cells with Chlamydia pneumoniae, J. Infect. Dis. 181:1096.

    CAS  PubMed  Google Scholar 

  30. Puolakkainen, M., Campbell, L. A., Lin, T. M., Richards, T., Patton, D. L., and Kuo, C. C., 2003, Cell-to-cell contact of human monocytes with infected arterial smooth-muscle cells enhances growth of Chlamydia pneumoniae, J. Infect. Dis. 187:435.

    Article  CAS  PubMed  Google Scholar 

  31. Kaukoranta-Tolvanen, S. E., Laurila, A. L., Saikku, P., Leinonen, M., and Laitinen, K., 1995, Experimental Chlamydia pneumoniae infection in mice: Effect of reinfection and passive immunization, Microb. Pathog. 18:279.

    CAS  PubMed  Google Scholar 

  32. Heinemann, M., Susa, M., Simnacher, U., Marre, R., and Essig, A., 1996, Growth of Chlamydia pneumoniae induces cytokine production and expression of CD 14 in a human monocytic cell line, Infect. Immun. 64:4872.

    CAS  PubMed  Google Scholar 

  33. Kaukoranta-Tolvanen, S. S., Ronni, T., Leinonen, M., Saikku, P., and Laitinen, K., 1996, Expression of adhesion molecules on endothelial cells stimulated by Chlamydia pneumoniae, Microb. Pathog. 21:407.

    CAS  PubMed  Google Scholar 

  34. Halme, S., Latvala, J., Karttunen, R., Palatsi, I., Saikku, P., and Surcel, H. M., 2000, Cell-mediated immune response during primary Chlamydia pneumoniae infection, Infect. Immun. 68:7156.

    Article  CAS  PubMed  Google Scholar 

  35. Maksymowych, W. P., and Kane, K. P., 2000, Bacterial modulation of antigen processing and presentation, Microb. Infect. 2:199.

    CAS  Google Scholar 

  36. Halme, S., Saikku, P., and Surcel, H. M., 1997, Characterization of Chlamydia pneumoniae antigens using human T cell clones, Scand. J. Immunol. 45:378.

    Article  CAS  PubMed  Google Scholar 

  37. Stephens, R. S., Kalman, S., Lammel, C., Fan, J., Marathe, R., Aravind, L., Mitchell, W., Olinger, L., Tatusov, R. L., Zhao, Q., Koonin, E. V., and Davis, R. W., 1998, Genome sequence of an obligate intracellular pathogen of humans: Chlamydia trachomatis [see comments], Science 282:754.

    Article  CAS  PubMed  Google Scholar 

  38. Kalman, S., Mitchell, W., Marathe, R., Lammel, C., Fan, J., Hyman, R. W., Olinger, L., Grimwood, J., Davis, R. W., and Stephens, R. S., 1999, Comparative genomes of Chlamydia pneumoniae and C. trachomatis, Nat. Genet. 21:385.

    CAS  PubMed  Google Scholar 

  39. Fan, P., Dong, F., Huang, Y, and Zhong, G., 2002, Chlamydia pneumoniae secretion of a protease-like activity factor for degrading host cell transcription factors is required for major histocompatibility complex antigen expression, Infect. Immun. 70:345.

    Article  CAS  PubMed  Google Scholar 

  40. Shaw, A. C., Vandahl, B. B., Larsen, M. R., Roepstorff, P., Gevaert, K., Vandekerckhove, J., Christiansen, G., and Birkelund, S., 2002, Characterization of a secreted Chlamydia protease, Cell Microbiol. 4:411.

    Article  CAS  PubMed  Google Scholar 

  41. Nadareishvili, Z. G., Koziol, D. E., Szekely, B., Ruetzler, C., LaBiche, R., McCarron, R., and DeGraba, T. J., 2001, Increased CD8(+) T cells associated with Chlamydia pneumoniae in symptomatic carotid plaque, Stroke 32:1966.

    CAS  PubMed  Google Scholar 

  42. Bandholtz, L., Kreuger, M. R., Svanholm, C., Wigzell, H., and Rottengerg, M. E., Adjuvant modulation of the immune responses and the outcome of infection with Chlamydia pneumoniae, Clin.Exp. Immunol. 130:393.

    Google Scholar 

  43. Svanholm, C., Bandholtz, L., Castanos-Velez, E., Wigzell, H., and Rottenberg, M. E., 2000, Protective DNA immunization against Chlamydia pneumoniae, Scand. J. Immunol. 51:345.

    Article  CAS  PubMed  Google Scholar 

  44. Yang, X., HayGlass, K. T., and Brunham, R. C., 1996, Genetically determined differences in IL-10 and IFN-gamma responses correlate with clearance of Chlamydia trachomatis mouse pneumonitis infection, J. Immunol. 156:4338.

    CAS  PubMed  Google Scholar 

  45. Perry, L. L., Feilzer, K., and Caldwell, H. D., 1997, Immunity to Chlamydia trachomatis is mediated by T helper 1 cells through IFN-gamma-dependent and-independent pathways, J.Immunol. 158:3344.

    CAS  PubMed  Google Scholar 

  46. Wang, S., Fan, Y., Brunham, R. C., and Yang, X., 1999, IFN-gamma knockout mice show Th2-associated delayed-type hypersensitivity and the inflammatory cells fail to localize and control chlamydial infection, Eur. J. Immunol. 29:3782.

    CAS  PubMed  Google Scholar 

  47. Vuola, J. M., Puurula, V., Anttila, M., Mäkelä, P. H., and Rautonen, N., 2000, Acquired immunity to Chlamydia pneumoniae is dependent on gamma interferon in two mouse strains that initially differ in this respect after primary challenge, Infect. Immun. 68:960.

    Article  CAS  PubMed  Google Scholar 

  48. Rottenberg, M. E., Gigliotti Rothfuchs, A., Gigliotti, D., Ceausu, M., Une, C., Levitsky, V., and Wigzell, H., 2000, Regulation and role of IFN-gamma in the innate resistance to infection with Chlamydia pneumoniae, J. Immunol. 164:4812.

    CAS  PubMed  Google Scholar 

  49. Geng, Y., Shane, R. B., Berencsi, K., Gonczol, E., Zaki, M. H., Margolis, D.J., Trinchieri, G., and Rook, A. H., 2000, Chlamydia pneumoniae inhibits apoptosis in human peripheral blood mononuclear cells through induction of IL-10, J. Immunol. 164:5522.

    CAS  PubMed  Google Scholar 

  50. Byrne, G. I., Grubbs, B., Marshall, T. J., Schachter, J., and Williams, D. M., 1988, Gamma interferon-mediated cytotoxicity related to murine Chlamydia trachomatis infection, Infect. Immun. 56:2023.

    CAS  PubMed  Google Scholar 

  51. Rottenberg, M. E., Gigliotti-Rothfuchs, A., and Wigzell, H., 2002, The role of IFN-gamma in the outcome of chlamydial infection, Curr. Opin. Immunol. 14:444.

    Article  CAS  PubMed  Google Scholar 

  52. Yang, X., 2001, Distinct function of Th1 and Th2 type delayed type hypersensitivity: Protective and pathological reactions to chlamydial infection, Microsc. Res. Tech. 53:273.

    Article  CAS  PubMed  Google Scholar 

  53. Holland, M.J., Bailey, R. L., Conway, D.J., Culley, F., Miranpuri, G., Byrne, G. I., Whittle, H. C., and Mabey, D. C., 1996, T helper type-1 (Th1)/Th2 profiles of peripheral blood mononuclear cells (PBMC): Responses to antigens of Chlamydia trachomatis in subjects with severe trachomatous scarring, Clin. Exp. Immun. 105:429.

    CAS  PubMed  Google Scholar 

  54. Kinnunen, A. H., Surcel, H. M., Lehtinen, M., Karhukorpi, J., Tiitinen, A., Halttunen, M., Bloigu, A., Morrison, R. P., Karttunen, R., and Paavonen, J., 2002, HLA DQ alleles and interleukin-10 polymorphism associated with Chlamydia trachomatis-related tubal factor infertility: A case-control study, Hum. Reprod. 17:2073.

    Article  CAS  PubMed  Google Scholar 

  55. Mosmann, T. R., and Coffman, R. L., 1989, TH1 and TH2 cells: Different patterns of lymphokine secretion lead to different functional properties, Ann. Rev. Immun. 7:145.

    CAS  Google Scholar 

  56. Romagnani, S., Parronchi, P., D’Elios, M. M., Romagnani, P., Annunziato, F., Piccinni, M. P., Manetti, R., Sampognaro, S., Mavilia, C., De Carli, M., Maggi, E., and Del Prete, G. F., 1997, An update on human Th1 and Th2 cells, Int. Arch. Allerg. Immun. 113:153.

    CAS  Google Scholar 

  57. Tseng, C. T., and Rank, R. G., 1998, Role of NK cells in early host response to chlamydial genital infection, Infect. Immun. 66:5867.

    CAS  PubMed  Google Scholar 

  58. Fenton, M. J., Vermeulen, M. W., Kim, S., Burdick, M., Strieter, R. M., and Kornfeld, H., 1997, Induction of gamma interferon production in human alveolar macrophages by Mycobacterium tuberculosis, Infect. Immun. 65:5149.

    CAS  PubMed  Google Scholar 

  59. Rothfuchs, A. G., Gigliotti, D., Palmblad, K., Andersson, U., Wigzell, H., and Rottenberg, M. E., 2001, IFN-alpha beta-dependent, IFN-gamma secretion by bone marrow-derived macrophages controls an intracellular bacterial infection, J. Immunol. 167:6453.

    CAS  PubMed  Google Scholar 

  60. Frucht, D. M., Fukao, T., Bogdan, C., Schindler, H., O’Shea, J.J., and Koyasu, S., 2001, IFN-gamma production by antigen-presenting cells: Mechanisms emerge, Trends Immunol. 22:556.

    Article  CAS  PubMed  Google Scholar 

  61. Stagg, A.J., Stackpoole, A., Elsley, W.J., and Knight, S. C., 1993, Acquisition of chlamydial antigen by dendritic cells and monocytes, Adv. Exp. Med. Biol. 329:581.

    CAS  PubMed  Google Scholar 

  62. Ojcius, D. M., Bravo de Alba, Y., Kanellopoulos, J. M., Hawkins, R. A., Kelly, K. A., Rank, R. G., and Dautry-Varsat, A., 1998, Internalization of Chlamydia by dendritic cells and stimulation of Chlamydia-specific T cells, J. Immunol. 160:1297.

    CAS  PubMed  Google Scholar 

  63. Airenne, S., Surcel, H. M., Bloigu, A., Laitinen, K., Saikku, P., and Laurila, A., 2000, The resistance of human monocyte-derived macrophages to Chlamydia pneumoniae infection is enhanced by interferon-gamma, Apmis. 108:139.

    Article  CAS  PubMed  Google Scholar 

  64. Airenne, S., Kinnunen, A., Leinonen, M., Saikku, P., and Surcel, H.-M., 2002, Secretion of IL-10 and IL-12 in Chlamydia pneumoniae infected human monocytes, presented at Chlamydial Infections Proceedings of the Tenth International Symposium on Human Chlamydial Infections, Antalya, Turkey.

    Google Scholar 

  65. Nicod, L. P., Cochand, L., and Dreher, D., 2000, Antigen presentation in the lung: Dendritic cells and macrophages, Sarc. Vasc. Diff. Lung Dis. 17:246.

    CAS  Google Scholar 

  66. Igietseme, J. U., Smith, K., Simmons, A., and Rayford, P. L., 1995, Effect of gamma-irradiation on the effector function of T lymphocytes in microbial control, Int. J. Rad. Biol. 67:557.

    CAS  PubMed  Google Scholar 

  67. Su, H., and Caldwell, H. D., 1995, CD4+ T cells play a significant role in adoptive immunity to Chlamydia trachomatis infection of the mouse genital tract, Infect. Immun. 63:3302.

    CAS  PubMed  Google Scholar 

  68. Morrison, R. P., Feilzer, K., and Tumas, D. B., 1995, Gene knockout mice establish a primary protective role for major histocompatibility complex class II-restricted responses in Chlamydia trachomatis genital tract infection, Infect. Immun. 63:4661.

    CAS  PubMed  Google Scholar 

  69. Penttilä, J. M., Anttila, M., Varkila, K., Puolakkainen, M., Sarvas, M., Mäkelä, P. H., and Rautonen, N., 1999, Depletion of CD8+ cells abolishes memory in acquired immunity against Chlamydia pneumoniae in BALB/c mice, Immunology 97:490.

    PubMed  Google Scholar 

  70. Rank, R. G., 1999, Models of immunity, in: Chlamydia: Intracellular Biology, Pathogenesis and Immunity (R. S. Stephens, ed.), American society for Microbiology, Washington, p. 239.

    Google Scholar 

  71. Li, L., Sad, S., Kagi, D., and Mosmann, T. R., 1997, CD8T c1 and T c2 cells secrete distinct cytokine patterns in vitro and in vivo but induce similar inflammatory reactions, J. Immunol. 158:4152.

    CAS  PubMed  Google Scholar 

  72. Mosmann, T. R., Li, L., and Sad, S., 1997, Functions of CD8 T-cell subsets secreting different cytokine patterns, Semin. Immunol. 9:87.

    Article  CAS  PubMed  Google Scholar 

  73. Mayer, L., 1997, Review article: Local and systemic regulation of mucosal immunity, Aliment. Pharmacol. Ther. 11(Suppl. 3):81.

    PubMed  Google Scholar 

  74. Hingorani, M., Metz, D., and Lightman, S. L., 1997, Characterisation of the normal conjunctival leukocyte population, Exp. Eye Res. 64:905.

    Article  CAS  PubMed  Google Scholar 

  75. Surcel, H. M., Syrjälä, H., Leinonen, M., Saikku, P., and Herva, E., 1993, Cell-mediated immunity to Chlamydia pneumoniae measured as lymphocyte blast transformation in vitro, Infect. Immun. 61:2196.

    CAS  PubMed  Google Scholar 

  76. Braun, J., Laitko, S., Treharne, J., Eggens, U., Wu, P., Distler, A., and Sieper, J., 1994, Chlamydia pneumoniae —A new causative agent of reactive arthritis and undifferentiated oligoarthritis, Ann. Rheum. Dis. 53:100.

    CAS  PubMed  Google Scholar 

  77. Halme, S., von Hertzen, L., Bloigu, A., Kaprio, J., Koskenvuo, M., Leinonen, M., Saikku, P., and Surcel, H. M., 1998, Chlamydia pneumoniae-specific cell-mediated and humoral immunity in healthy people, Scand. J. Immun. 47:517.

    CAS  Google Scholar 

  78. Hanna, L., Schmidt, L., Sharp, M., Stites, D. P., and Jawetz, E., 1979, Human cell-mediated immune responses to chlamydial antigens, Infect. Immun. 23:412.

    CAS  PubMed  Google Scholar 

  79. Brunham, R. C., Martin, D. H., Kuo, C. C., Wang, S. P., Stevens, C. E., Hubbard, T., and Holmes, K. K., 1981, Cellular immune response during uncomplicated genital infection with Chlamydia trachomatis in humans, Infect. Immun. 34:98.

    CAS  PubMed  Google Scholar 

  80. Halme, S., Syrjälä, H., Bloigu, A., Saikku, P., Leinonen, M., Airaksinen, J., and Surcel, H. M., 1997, Lymphocyte responses to Chlamydia antigens in patients with coronary heart disease, Eur. Heart J. 18:1095.

    CAS  PubMed  Google Scholar 

  81. Mabey, D. C., Holland, M. J., Viswalingam, N. D., Goh, B. T., Estreich, S., Macfarlane, A., Dockrell, H. M., and Treharne, J. D., 1991, Lymphocyte proliferative responses to chlamydial antigens in human chlamydial eye infections, Clin. Exp. Immunol. 86:37.

    CAS  PubMed  Google Scholar 

  82. von Hertzen, L., Surcel, H. M., Kaprio, J., Koskenvuo, M., Bloigu, A., Leinonen, M., and Saikku, P., 1998, Immune responses to Chlamydia pneumoniae in twins in relation to gender and smoking, J. Med. Microbiol. 47:441.

    Google Scholar 

  83. File, T. M., 2000, The epidemiology of respiratory tract infections, Semin. Respir. Infect. 15:184.

    CAS  PubMed  Google Scholar 

  84. Smieja, M., Leigh, R., Petrich, A., Chong, S., Kamada, D., Hargreave, F. E., Goldsmith, C. H., Chernesky, M., and Mahony, J. B., 2002, Smoking, season, and detection of Chlamydia pneumoniae DNA in clinically stable COPD patients, BMC Infect. Dis. 2:12.

    PubMed  Google Scholar 

  85. Sopori, M. L., and Kozak, W., 1998, Immunomodulatory effects of cigarette smoke, J. Neuroimmunol. 83:148.

    Article  CAS  PubMed  Google Scholar 

  86. Caspar-Bauguil, S., Puissant, B., Nazzal, D., Lefevre, J. C., Thomsen, M., Salvayre, R., and Benoist, H., 2000, Chlamydia pneumoniae induces interleukin-10 production that down-regulates major histocompatibility complex class I expression, J. Infect. Dis. 182:1394.

    Article  CAS  PubMed  Google Scholar 

  87. Zhong, G., Fan, T., and Liu, L., 1999, Chlamydia inhibits interferon gamma-inducible major histocompatibility complex class II expression by degradation of upstream stimulatory factor 1, J. Exp. Med. 189:1931.

    Article  CAS  PubMed  Google Scholar 

  88. Zhong, G., Liu, L., Fan, T., Fan, P., and Ji, H., 2000, Degradation of transcription factor RFX5 during the inhibition of both constitutive and interferon gamma-inducible major histocompatibility complex class I expression in chlamydia-infected cells, J. Exp. Med. 191:1525.

    CAS  PubMed  Google Scholar 

  89. Zhong, G., Fan, P., Ji, H., Dong, F., and Huang, Y., 2001, Identification of a chlamydial protease-like activity factor responsible for the degradation of host transcription factors, J. Exp. Med. 193:935.

    Article  CAS  PubMed  Google Scholar 

  90. Rodel, J., Groh, A., Vogelsang, H., Lehmann, M., Hartmann, M., and Straube, E., 1998, Beta interferon is produced by Chlamydia trachomatis-infected fibroblast-like synoviocytes and inhibits gamma interferon-induced HLA-DR expression, Infect. Immun. 66:4491.

    CAS  PubMed  Google Scholar 

  91. Grayston, J. T., Kuo, C.-C., Campbell, L. A., and Wang, S.-P., 1989, Chlamydia pneumoniae sp. nov. for Chlamydia sp. strain TWAR, Int. J. Syst. Bact. 39:88.

    Google Scholar 

  92. Saikku, P., Wang, S. P., Kleemola, M., Brander, E., Rusanen, E., and Grayston, J. T., 1985, An epidemic of mild pneumoniae due to an unusual strain of Chlamydia psittaci, J. Infect. Dis. 151:832.

    CAS  PubMed  Google Scholar 

  93. Grayston, J. T., Kuo, C.-C., Wang, S.-P., and Altman, J., 1986, A new Chlamydia psittaci strain, TWAR, isolated in acute respiratory tract infection, New Eng. J. Med. 315:161.

    CAS  PubMed  Google Scholar 

  94. Wang, S.-P., and Grayston, J. T., 1970, Immunologic relationship between genital TRIC, lymphogranuloma venereum, and organisms in a new microtiter indirect immunofluo-rescence test, Am. J. Ophthal. 70:367.

    CAS  PubMed  Google Scholar 

  95. Wang, S., 2000, The microimmunofluorescence test for Chlamydia pneumoniae infection: Technique and interpretation, J. Infect. Dis. 181:S421.

    Article  CAS  PubMed  Google Scholar 

  96. Dowell, S. F., Peeling, R. W., Boman, J., Carlone, G. M., Fields, B. S., Guarner, J., Hammerschlag, M. R., Jackson, L. A., Kuo, C. C., Maass, M., Messmer, T. O., Talkington, D. F., Tondella, M. L., and Zaki, S. R., 2001, Standardizing Chlamydia pneumoniae assays: Recommendations from the Centers for Disease Control and Prevention (USA) and the Laboratory Centre for Disease Control (Canada), Clin. Infect. Dis. 33:492.

    CAS  PubMed  Google Scholar 

  97. Grayston, J. T., Campbell, L. A., Kuo, C. C., Mordhorst, C. H., Saikku, P., Thom, D. H., and Wang, S. P., 1990, A new respiratory tract pathogen: Chlamydia pneumoniae strain TWAR, J. Infect. Dis. 161:618.

    CAS  PubMed  Google Scholar 

  98. Ekman, M. R., Leinonen, M., Syrjälä, H., Linnanmäki, E., Kujala, P., and Saikku, P., 1993, Evaluation of serological methods in the diagnosis of Chlamydia pneumoniae pneumonia during an epidemic in Finland, Eur. J. Clin. Microbiol. Infect. Dis. 12:756.

    Article  CAS  PubMed  Google Scholar 

  99. Ekman, M. R., Grayston, J. T., Visakorpi, R., Kleemola, M., Kuo, C. C., and Saikku, P., 1993, An epidemic of infections due to Chlamydia pneumoniae in military conscripts, Clin. Infect. Dis. 17:420.

    CAS  PubMed  Google Scholar 

  100. Kauppinen, M., and Saikku, P., 1995, Pneumonia due to Chlamydia pneumoniae: Prevalence, clinical features, diagnosis, and treatment, Clin. Infect. Dis. 21(Suppl. 3):5244.

    Google Scholar 

  101. Block, S., Hedrick, J., Hammerschlag, M. R., Cassell, G. H., and Craft, J. C., 1995, Mycoplasma pneumoniae and Chlamydia pneumoniae in pediatric community-acquired pneumonia: Comparative efficacy and safety of clarithromycin vs. erythromycin ethylsuccinate, Pediatr. Infect. Dis. J. 14:471.

    CAS  PubMed  Google Scholar 

  102. Harris, J. A., Kolokathis, A., Campbell, M., Cassell, G. H., and Hammerschlag, M. R., 1998, Safety and efficacy of azithromycin in the treatment of community-acquired pneumonia in children, Pediatr. Infect. Dis. J. 17:865.

    CAS  PubMed  Google Scholar 

  103. Kutlin, A., Roblin, P. M., and Hammerschlag, M. R., 1998, Antibody response to Chlamydia pneumoniae infection in children with respiratory illness, J. Infect. Dis. 177:720.

    CAS  PubMed  Google Scholar 

  104. Gnarpe, J., Gnarpe, H., and Sundelof, B., 1991, Endemic prevalence of Chlamydia pneumoniae in subjectively healthy persons, Scand. J. Infect. Dis. 23:387.

    CAS  PubMed  Google Scholar 

  105. Hyman, C. L., Roblin, P. M., Gaydos, C. A., Quinn, T. C., Schachter, J., and Hammerschlag, M. R., 1995, Prevalence of asymptomatic nasopharyngeal carriage of Chlamydia pneumoniae in subjectively healthy adults: Assessment by polymerase chain reaction-enzyme immunoassay and culture, Clin. Infect. Dis. 20:1174.

    CAS  PubMed  Google Scholar 

  106. Miyashita, N., Fukano, H., Niki, Y., Matsushima, T., and Okimoto, N., 2001, Etiology of community-acquired pneumonia requiring hospitalization in Japan, Chest 119:1295.

    Article  CAS  PubMed  Google Scholar 

  107. Dalhoff, K., and Maass, M., 1996, Chlamydia pneumoniae pneumonia in hospitalized patients. Clinical characteristics and diagnostic value of polymerase chain reaction detection in BAL, Chest 110:351.

    CAS  PubMed  Google Scholar 

  108. Thom, D. H., Grayston, J. T., Campbell, L. A., Kuo, C. C., Diwan, V. K., and Wang, S. P., 1994, Respiratory infection with Chlamydia pneumoniae in middle-aged and older adult outpatients, Eur. J. Clin. Microbiol. Infect. Dis. 13:785.

    Article  CAS  PubMed  Google Scholar 

  109. Aldous, M. B., Grayston, J. T., Wang, S. P., and Foy, H. M., 1992, Seroepidemiology of Chlamydia pneumoniae TWAR infection in Seattle families, 1966–1979, J. Infect. Dis. 166:646.

    CAS  PubMed  Google Scholar 

  110. Patnode, D., Wang, S.-P., and Grayston, J. T., 1990, Persistence of Chlamydia pneumoniae, Strain TWAR Micro-Immunofluorescent Antibody, Cambridge.

    Google Scholar 

  111. Grayston, J. T., Campbell, L. A., Kuo, C.-C., Mordhorst, C. H., Saikku, P., Thom, D. H., and Wang, S.-P., 1990, A new respiratory tract pathogen: Chlamydia pneumoniae strain TWAR, J.Infect. Dis. 161:618.

    CAS  PubMed  Google Scholar 

  112. Karvonen, M., Tuomilehto, J., Pitkäniemi, J., Naukkarinen, A., and Saikku, P., 1994, Importance of smoking for Chlamydia pneumoniae seropositivity, Int. J. Epidemiol. 23:1315.

    CAS  PubMed  Google Scholar 

  113. Kawa, D. E., and Stephens, R. S., 2002, Antigenic topology of chlamydial PorB protein and identification of targets forimmune neutralization of infectivity, J. Immunol. 168:5184.

    CAS  PubMed  Google Scholar 

  114. Wiedmann-Al-Ahmad, M., Schuessler, P., and Freidank, H. M., 1997, Reactions of polyclonal and neutralizing anti-p54 monoclonal antibodies with an isolated, species-specific 54-kilodalton protein of Chlamydia pneumoniae, Clin. Diag. Lab. Immunol. 4:700.

    CAS  Google Scholar 

  115. Peterson, E. M., Cheng, X., Qu, Z., and de La Maza, L. M., 1996, Characterization of the murine antibody response to peptides representing the variable domains of the major outer membrane protein of Chlamydia pneumoniae, Infect. Immun. 64:3354.

    CAS  PubMed  Google Scholar 

  116. Donati, M., Rumpianesi, F., Pavan, G., D’Apote, L., and Cevenini, R., 1996, Detection of serum antibodies against Chlamydia pneumoniae by in vitro neutralization and microimmunofluorescence assays, Zentralblatt fur Bakteriologie 284:52.

    CAS  PubMed  Google Scholar 

  117. Qu, Z., Cheng, X., de la Maza, L. M., and Peterson, E. M., 1993, Characterization of a neutralizing monoclonal antibody directed at variable domain I of the major outer membrane protein of Chlamydia trachomatis C-complex serovars, Infect. Immun. 61:1365.

    CAS  PubMed  Google Scholar 

  118. Peterson, E. M., Cheng, X., Markoff, B. A., Fielder, T. J., and de la Maza, L. M., 1991, Functional and structural mapping of Chlamydia trachomatis species-specific major outer membrane protein epitopes by use of neutralizing monoclonal antibodies, Infect. Immun. 59:4147.

    CAS  PubMed  Google Scholar 

  119. Peterson, E. M., de La Maza, L. M., Brade, L., and Brade, H., 1998, Characterization of a neutralizing monoclonal antibody directed at the lipopolysaccharide of Chlamydia pneumoniae, Infect. Immun. 66:3848.

    CAS  PubMed  Google Scholar 

  120. Rank, R. G., and Batteiger, B. E., 1989, Protective role of serum antibody in immunity to chlamydial genital infection, Infect. Immun. 57:299.

    CAS  PubMed  Google Scholar 

  121. Cotter, T. W., Meng, Q., Shen, Z. L., Zhang, Y. X., Su, H., and Caldwell, H. D., 1995, Protective efficacy of major outer membrane protein-specific immunoglobulin A (IgA) and IgG monoclonal antibodies in a murine model of Chlamydia trachomatis genital tract infection, Infect. Immun. 63:4704.

    CAS  PubMed  Google Scholar 

  122. Su, H., Feilzer, K., Caldwell, H. D., and Morrison, R. P., 1997, Chlamydia trachomatis genital tract infection of antibody-deficient gene knockout mice, Infect. Immun. 65:1993.

    CAS  PubMed  Google Scholar 

  123. Morrison, S. G., Su, H., Caldwell, H. D., and Morrison, R. P., 2000, Immunity to murine Chlamydia trachomatis genital tract reinfection involves B cells and CD4(+) T cells but not CD8(+) T cells, Infect. Immun. 68:6979.

    CAS  PubMed  Google Scholar 

  124. Byrne, G. I., and Moulder, J. W., 1978, Parasite-specified phagocytosis of Chlamydia psittaci and Chlamydia trachomatis by L and HeLa cells, Infect. Immun. 19:598.

    CAS  PubMed  Google Scholar 

  125. Su, H., and Caldwell, H. D., 1991, In vitro neutralization of Chlamydia trachomatis by monovalent Fab antibody specific to the major outer membrane protein, Infect. Immun. 59:2843.

    CAS  PubMed  Google Scholar 

  126. Wyrick, P. B., Brownridge, E. A., and Ivins, B. E., 1978, Interaction of Chlamydia psittaci with mouse peritoneal macrophages, Infect. Immun. 19:1061.

    CAS  PubMed  Google Scholar 

  127. Caldwell, H. D., and Perry, L. J., 1982, Neutralization of Chlamydia trachomatis infectivity with antibodies to the major outer membrane protein, Infect. Immun. 38:745.

    CAS  PubMed  Google Scholar 

  128. Moore, T., Ananaba, G. A., Bolier, J., Bowers, S., Belay, T., Eko, F. O., and Igietseme, J. U., 2002, Fc receptor regulation of protective immunity against Chlamydia trachomatis, Immunology 105:213.

    Article  CAS  PubMed  Google Scholar 

  129. Geng, Y., Berencsi, K., Gyulai, Z., Valyi-Nagy, T., Gonczol, E., and Trinchieri, G., 2000, Roles of interleukin-12 and gamma interferon in murine Chlamydia pneumoniae infection, Infect. Immun. 68:2245.

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Microbiology, National Public Health Institute, 90101, Oulu, Finland

    Heljä-Marja Surcel

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  1. University of South Florida College of Medicine, Tampa, Florida

    Herman Friedman

  2. Osaka University, Osaka, Japan

    Yoshimasa Yamamoto

  3. University of Pisa, Pisa, Italy

    Mauro Bendinelli

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Surcel, HM. (2005). Chlamydia pneumoniae Infection and Diseases: Immunity to Chlamydia pneumoniae. In: Friedman, H., Yamamoto, Y., Bendinelli, M. (eds) Chlamydia pneumoniae Infection and Disease. Infectious Agents and Pathogenesis. Springer, Boston, MA. https://doi.org/10.1007/0-306-48741-1_7

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  • DOI: https://doi.org/10.1007/0-306-48741-1_7

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