Abstract
Among neoplasms, the severity and relevance of metastasis is perhaps most striking in the case of melanoma where surgical resection would conduce cure if not for the subsequent complications of distant metastatic foci. Compounding this notion are statistics revealing that the number of cases of malignant melanoma have doubled each of the last four decades (1) and autopsies of patients presenting with melanoma reveal lung invasion in approximately ninety percent of cases (2). Thus, a clear understanding of the mechanisms governing melanoma metastasis and the role of metastasis suppressor genes in controlling this cascade is essential. The KiSS1 metastasis suppressor gene, identified and functional in melanoma models, provides us with just such an opportunity. As we endeavor to elucidate the role of KiSS1, an understanding of melanomametastasis suppression mediated by chromosome 6, which provided the platform for the discovery of KiSS1, similarly proffers important clues to understanding the mechanism of KiSS1 metastasis suppression.
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Harms, J.F., Welch, D.R. (2002). The Role of KISS1 in Melanoma Metastasis Suppression. In: Welch, D.R. (eds) Cancer Metastasis — Related Genes. Cancer Metastasis — Biology and Treatment, vol 3. Springer, Dordrecht. https://doi.org/10.1007/0-306-47821-8_12
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DOI: https://doi.org/10.1007/0-306-47821-8_12
Publisher Name: Springer, Dordrecht
Print ISBN: 978-1-4020-0522-0
Online ISBN: 978-0-306-47821-5
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