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Model Systems for Assessing Cognitive Function: Implications for HIV-1 Infection and Drugs of Abuse

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Neuroimmune Circuits, Drugs of Abuse, and Infectious Diseases

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 493))

Abstract

Memory deficits are common among drug abusers and in those with chronic neurodegenerative disorders. Currently, the mechanisms through which diverse neurophysiologic processes alter memory are not known. This review describes the current systems and rationale for studying memory formation, consolidation, and recall. Special attention is given to physiologic (hippocampal long-term potentiation) and behavioral animal models. The principles and methods described can be applied to studies of diverse clinical disorders.

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Authors and Affiliations

  1. The Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, NE, 68198-5215, USA

    Walter E. Zink, Jeffrey Boyle, Yuri Persidsky, Huangui Xiong & Howard E. Gendelman

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  1. Walter E. Zink
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  2. Jeffrey Boyle
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  3. Yuri Persidsky
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  4. Huangui Xiong
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  5. Howard E. Gendelman
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Editors and Affiliations

  1. College of Medicine, University of South Florida, Tampa, Florida

    Herman Friedman  & Thomas W. Klein  & 

  2. Georgia Mental Health Institute, Emory University, Atlanta, Georgia

    John J. Madden

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Zink, W.E., Boyle, J., Persidsky, Y., Xiong, H., Gendelman, H.E. (2002). Model Systems for Assessing Cognitive Function: Implications for HIV-1 Infection and Drugs of Abuse. In: Friedman, H., Klein, T.W., Madden, J.J. (eds) Neuroimmune Circuits, Drugs of Abuse, and Infectious Diseases. Advances in Experimental Medicine and Biology, vol 493. Springer, Boston, MA. https://doi.org/10.1007/0-306-47611-8_2

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