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Identifying the Mechanisms of Trypanotolerance in Cattle

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The African Trypanosomes

Part of the book series: World Class Parasites ((WCPA,volume 1))

Abstract

Some West African cattle breeds such as N’Dama have survived in tsetse-infected areas for thousands of years and are productive under trypanosome challenge, a trait known as trypanotolerance. Elucidation of the mechanisms of trypanotolerance could lead to new options for disease control. This review describes responses in trypanotolerant and trypanosusceptible breeds of cattle, and compares them with responses in mouse models. It focuses on the roles of haemopoietic tissue, T lymphocytes and antibodies in resistance to trpanosomiasis.

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Authors and Affiliations

  1. International Livestock Research Institute, P.O. Box 30709, Nairobi, Kenya

    J. Naessens

  2. Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, USA

    D.J. Grab

  3. I.W.T., Bischoffsheimlaan 25, 1000, Brussels, Belgium

    M. Sileghem

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  1. J. Naessens
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  2. D.J. Grab
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  3. M. Sileghem
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© 2002 Kluwer Academic Publishers

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Naessens, J., Grab, D., Sileghem, M. (2002). Identifying the Mechanisms of Trypanotolerance in Cattle. In: The African Trypanosomes. World Class Parasites, vol 1. Springer, Boston, MA. https://doi.org/10.1007/0-306-46894-8_8

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  • DOI: https://doi.org/10.1007/0-306-46894-8_8

  • Publisher Name: Springer, Boston, MA

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