Summary
Transgenic plants have proved to be a highly promising biofactory for production of recombinant proteins. “Plantibodies” have been among the first to be extensively worked on and today constitute a competitive field of commercial interest, especially for therapeutic antibodies to be produced expectedly around 10–100kg per year for an individual antibody.
A first non-therapeutic tumor imaging antibody has been produced in transgenic maize by Monsanto in cooperation with NeoRx providing the antibody. First clinical trials have been successfully completed and orally communicated so far at several conferences. Another “plantibody” having been brought to successful clinical trials is an anti-caries active agent [20]. These two plant produced antibodies are the first examples of a new commercial technology with a huge economic potential. Transgenic plants as bioreactors will allow the development of a large number of potential therapeutic proteins into successful pharmaceuticals by enabling large scale production at low cost. Therefore, they will have signific t implications on the future development of the pharmaceutical industry.
Furthermore, plant bioreators for production of a variety of different peptides are under development and will dramatically change the cost and availability of these new materials.
In addition, peptides also are important as active agents in plant resistance engineering
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© 2002 Kluwer Academic Publishers
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Düring, K. (2002). Transgenic Plants for Large Scale Production of Peptides and Proteins. In: Self-Assembling Peptide Systems in Biology, Medicine and Engineering. Springer, Dordrecht. https://doi.org/10.1007/0-306-46890-5_6
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DOI: https://doi.org/10.1007/0-306-46890-5_6
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