Skip to main content
SpringerLink
Log in

Design of Synthetic Branched Chain Polymeric Polypeptides for Targeting/Delivering Bioactive Molecules

  • Chapter
Self-Assembling Peptide Systems in Biology, Medicine and Engineering

  • 240 Accesses

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.00
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Seymour, L. W.: Passive tumour targeting of soluble macromolecules and drug conjugates. Crit. Rev the Drug. Syst. 9 (1992), 135–162.

    CAS  Google Scholar 

  2. Johnson, K. P., Brooks, B. R., Cohen, J. A., Ford, C. C., Goldstein, J., Lisak, R. P., Myers, L. W., Panitch, H. S., Rose, J. W., Schiffer, R. B., Vollmer, T., Weiner, L. P. and Wolinsky, J. S.: Extended use of glatiramer acetate (Copane) is well tolerated and maintains its clinical effect onmultiple sclerosis relapse rate and degreee of disability. Copolymer 1. Multiple Sclerosis Discussion Group. Neurology 50 (1998), 701–708.

    CAS  PubMed  Google Scholar 

  3. Javaherian, K., and McDanal, C.: Random copolymers containing specific ratios of negatively charged and aromatic amino acids bind V3 disulfide loop and neutralize diverse HIV type I isolates. AIDS Res. Hum. Retroviruses 10 (1995) 1163–1168.

    Google Scholar 

  4. Jackson, D.C., O’Brien-Simpson, N., Ede, N.J., and Brown, L.E.: Free radical induced polymerization of synthetic peptides into polymeric immunogens. Vaccine 15 (1997) 1697–1705.

    Article  CAS  PubMed  Google Scholar 

  5. Tsikaris, V., Sakarellos, C., Cung, M.T., Marraud, M., and Sakarellos-Daitsiotis, M. Concept and design of a new class of sequential oligopeptide carriers (SOC) for covalent attachment of multiple antigenic peptides. Biopolymers, 381 (1996) 291–293.

    Google Scholar 

  6. Burnham, N.L.: Polymers for delivering peptides and proteins. Am. J. Hosp. Pharm. 51 (1994) 210–218.

    CAS  PubMed  Google Scholar 

  7. Gombotz, W.R., and Pettit, D.K.: Biodegradable polymers for protein and peptide drug delivery. Bioconjugate Chem. 6 (1995) 332–35I.

    Article  CAS  Google Scholar 

  8. Friend, D. R., and Pangburn, S.: Site-specific drug delivery. Medicinal Research Review 7 (1987) 53

    CAS  Google Scholar 

  9. Duncan, R.: Drug-polymer conjugates; potential for improved chemotherepy. Anti-Cancer Drugs, 3 (1992) 153–156.

    Google Scholar 

  10. Takakura, Y., and Hashida, M., Macromolecular drug carrier systems in cancer chemotherapy: macromolecular prodrugs. Critical Reviews in Oncology/Haematology 18 (I995) 207–23I.

    Google Scholar 

  11. Maeda, H., Seymour, L.W., and Miyamoto, Y.: Conjugates of anticancer agents and polymers: advantages of macromolecular therapeutics in vivo. Bioconjugate Chem., 3 (1992) 351–362.

    Article  CAS  Google Scholar 

  12. Vasey, P.A., Kaye, S.B., Morrison, R., Twelves, C., Wilson, P., Duncan, R., Thomson, A.H., Murray, L.S., Hilditch, T.E., Murray, T., Burtles, S., Fraier, D., Frigerio, E., and Cassidy, J.: Phase I clinical and pharmacokinetic study of PK1 [N-(2-hydroxypropyl)methacrylamide copolymer doxorubicin]: first member of a new class of chemotherapeutic agents — drug-polymer conjugates. Clinical Cancer Research 5 (1999) 83–94.

    CAS  PubMed  Google Scholar 

  13. Julyan, P.J., Seymour, L.W., Ferry. D.R., Daryani, S., Boivin, C.M., Doran, J., David, M.. Anderson, D., Christodoulou, C., Young, A.M., Hesslewood, S., and Kerr, D.J.: Preliminary clinical study of the distribution of HPMA copolymers bearing doxorubicin and galactosamine J. Controlled Release 57 (1999) 281–290.

    Article  CAS  Google Scholar 

  14. Del Giudice, G.: New carriers and adjuvants in the development of vaccines. Current Opinion in Immunology. 4 (1992) 454–459.

    PubMed  Google Scholar 

  15. Hudecz, F., and Toth, G.K. (1994) Synthetic peptide constructs to increase the immunogenicity of B-cell epitopes, in É. Rajnavolgyi (ed.), Synthetic’ peptides in the search for B-and T-cell epitopes R.G.Landes Company, Austin, pp. 97–119.

    Google Scholar 

  16. Gokulan, K., Khare, S., and Rao, D.N.: Increase in the immunogenicity of HIV peptide antigens by chemical linkage to polytuftsin (TKPR40). DNA Cell Biol. 18 (1999) 623–630.

    Article  CAS  PubMed  Google Scholar 

  17. Arnon, R.: Synthetic vaccines based on peptides, oligonucleotides and conjugate anigens. BEHRING Inst. Mitt. 98 (1997) 184–190.

    CAS  PubMed  Google Scholar 

  18. Ben-Yedidia, T., and Arnon, R.: Design of peptide and polypeptide vaccines. Current Opinion in Biotechnology 8 (1997) 442–448.

    Article  CAS  PubMed  Google Scholar 

  19. Hudecz, F., Votavova, H., Gaál, D., Sponar, J., Kajtdr, J., Blaha, K., and Szekerke, M. (1985) Branched polypeptides with a poly(L-lysine) backbone: synthesis, conformation and immunomodulation. in Ch.G. Gebelein, and Ch. E. Carraher (eds.) Polymeric, Materials in Medication Plenum Press, New York. pp. 265–289.

    Google Scholar 

  20. Mezo, G., Kajtdr, J., Hudecz, F. and Szekerke, M.: Carrier design: conformational studies of amino acid (X) and oligopeptide (X-DL-Ala,,,) substituted poly[L-lysine]. Biopolymers, 33 (1993) 873–883.

    CAS  PubMed  Google Scholar 

  21. Hudecz, F.: Design of synthetic branched-chain polypeptides as carriers for bioactive molecules. Anti-Cancer-Drugs 6 (1995) 171–193.

    CAS  PubMed  Google Scholar 

  22. Mezo, G., Kajtar, J., Nagy, I., Majer, Zs., Szekerke, M., and Hudecz, F.: Carrier design: Synthesis and conformational studies of poly[L-lysine] based branched polypeptides with hydroxyl groups. Biopolymers 42 (1997) 719–730.

    CAS  Google Scholar 

  23. Hudecz, F., Ga, D., Kurucz, I., Ldnyi, S., Kovdcs, A.L., Mezó, G., Rajnavélgyi, E., and Szekerke, M.: Carrier design: cytotoxicity and immunogenicity of synthetic branched polypeptides with poly(L-lysine) backbone. J. Controlled Relase 19 (1992) 231–243.

    CAS  Google Scholar 

  24. Clegg, J.A., Hudecz, F., Mezo, G., Pimm, M.V., Szekerke. M., and Baldwin, R.W.: Carrier design: biodistribution of branched polypeptides with poly-(L-lysine) backbone. Bioconjugate Chem., 2 (1990) 425–430.

    Google Scholar 

  25. Hudecz, F. and Szekerke, M.: Investigation of drug-protein interactions and the drug-carrier concept by the use of branched polypeptides as model systems. Synthesis and characterisation of the model peptides. Coll. Czech. Chem. Commun 45 (1980) 933–940.

    CAS  Google Scholar 

  26. Sela, M.: (1980) Chemical synthesis for the understanding of immune response phenomena and for their medical application. in C. Larralde, K. Wills, L. Ortiz-Ortiz. and M. Sela (eds.) Molecules, cells, and parasites in immunology Acad Press, New York, pp. 215–228.

    Google Scholar 

  27. Hudecz, F., and Szekerke, M.: Synthesis of new branched polypeptides with poly-lysine backbone. Coll Czech. Chem. Commun., 50 (1985) 103–113.

    Article  CAS  Google Scholar 

  28. Hudecz, F., Kovdcs, P., Kutassi-Kovdcs, S., and Kajtár, J.: GPC, CD and sedimentation analysis of poly-Lys and branched chain poly-Lys-poly-DL-Ala polypeptides. Colloid and Polymer Sci. 262 (1984) 208–212.

    CAS  Google Scholar 

  29. Hudecz, F., Kojima, Y., Miyamoto, Y., Kajtzr, J., and Maeda, H.: The effect of charge on the biodistribution of synthetic branched polypeptides in tumour bearing mice. J. Controlled Release 28 (1994) 301–302.

    Article  CAS  Google Scholar 

  30. Pimm, M.V., Clegg, J.A., Hudecz, F., and Baldwin, R.W.: In 111 labelling of branched polypeptide drug carrier with poly[L-lysine] backbone. Int. J. Pharmaceutics 79 (1992) 77–80.

    Article  CAS  Google Scholar 

  31. Idei, M., Dibo, G., Bogd‡n, K., Mezó, G., Horvdth, A,, Erchegyi, J., MészÁros, Gy., Teplán, I., Kéri, Gy., and Hudecz, F.: Analysis of macromolecular branched chain polypeptides by capillary electrophoresis and micellar electrokinetic chromatography. Electrophoresis 17 (1996) 1357–1360.

    CAS  PubMed  Google Scholar 

  32. Hudecz, F., Nagy, I.B., Kóczán, G., Alsina, M.A., and Reig, F. (2000) Carrier design: influence of charge on interaction of branched polymeric polypeptides with phospholipid model membranes. in E. Chiellini (ed.) Frontiers in Biomedical Polymers, Plenum Press, New York, (in press)

    Google Scholar 

  33. Kóczán, Gy., Remenyi, J., Hudecz, F.: Novel RP-HPLC analysis and purification of methotrexate-polymeric branched chain polypeptide conjugates. .J. Chromatography (submitted)

    Google Scholar 

  34. Hudecz, F., Pimm, M.V., Rajnavolgyi, E., Mezó, G., Fabra, A,, Gaá, D., Kovács. A.L., Horváth, A., and Szekerke. M.: Carrier design: New generation of polycationic branched polypeptides containing OH groups with prolonged blood survival and diminished in vitro cytotoxicity. Bioconjugate Chem. 10 (1999) 781–790.

    Article  CAS  Google Scholar 

  35. Marfey. P.: Determination of D-amino acids. II. Use of a bifunctional reagent, 1,5-difluoro-2,4-dinitrobenzene. Carlsberg Res. Commun. 49 (1984) 591–596.

    CAS  Google Scholar 

  36. Szokiin, Gy., Mezo, G., and Hudecz, F.: Application of Marfey’s reagent in racemization studies of amino acids and peptides. J.Chromatography 444 (1988) 115–122.

    Google Scholar 

  37. Votavova, H., Hudecz, F., Kajtár, J., Sponar, J., Blaha, K., and Szekerke, M. f Conformation of branched polypeptides based on poly(L-lysine). Effect of the ionic strength and of the presence of alcohols. Coll. Czech. Chem. Commun. 47 (1982) 3437–3446.

    CAS  Google Scholar 

  38. Votavova, H., Hudecz, F., Kajtár, J., Sponar, J., Blaha, K., and Szekerke, M.: Conformation of branched polypeptides based on poly(L-lysine): the effect of terminal amino acids in the branches. Collect. Czech. Chem. Commun. 50 (1985) 228–244.

    Article  CAS  Google Scholar 

  39. Mezo, G., Votavova, H., Hudecz, F., Kajtár, J., Sponar, J., and Szekerke, M.: Conformation of branched polypeptides: The influence of DL-alanine oligomer spacers in the side chains. Coll. Czech Chem. Commun., 53 (1988) 2843–2853.

    Article  CAS  Google Scholar 

  40. Mezo, G., Kajtiir, J., Hudecz, F., and Szekerke, M.: Carrier design: conformational studies of amino acid (X) and oligopeptide (X-DL-Alam) substituted poly[L-lysine] Biopolymers 33 (1993) 873–885.

    CAS  PubMed  Google Scholar 

  41. Nagy, I.B., Haro, I., Alsina, A., Reig, F., and Hudecz, F.: Interaction of branched chain polymeric polypeptides with phospholipid model membranes. Biopolymers 46 (1998) 169–179.

    Article  CAS  Google Scholar 

  42. Goupil, D. W., and Goodrich, F. C.: Interfacial conformational modifictions in a polypeptide. .J. Coll.Interf. Sci. 62 (1977) 142–148.

    Article  CAS  Google Scholar 

  43. Winterhalter, M., Byrner, H., Marzinka, S., Benz, R., and Kasianowicz, J. J.: 1995, Interaction of poly(ethylene-glycols) with air-water interfaces and lipid monolayers: investigation on surface pressure and surface potential. Biophys. J. 69 (1995) 1372–1381.

    Article  CAS  PubMed  Google Scholar 

  44. Van Deenen, L. L. M., Demel. R. A., Geurtz van Kessel. W. S. H., Kamp, H. H., Roelfsen, B., Veerkelij, A. J., Wirtz, K. W. A., and Zwall, R. F. A. (1976) in The structural basis of membrane function Y. Hatefi and L. Djavadi-Ohaniance (eds.) Academic Press, New York, pp. 21–38.

    Google Scholar 

  45. Cajal, Y., Alsina, M. A., Rabanal, F., and Reig, F.: A tluorescence and CD study on the interaction of synthetic lipophilic Hepatitis B virus preS(120–145) peptide analogues with phospholipid vesicles. Biopolymers 38 (1996) 607–618.

    Article  CAS  PubMed  Google Scholar 

  46. Chu, B.C.F., and Howell, S.B.: Differential toxicity of carrier bound methotrexate toward human lymphocytes,marrow and tumor cells. Biochem. Phamacol. 30 (1981) 2545–2552.

    CAS  Google Scholar 

  47. Gaál, D., Hudecz, F., Kov‡fcs, A.L., and Szekerke, M.: Immunomodulatory effect of synthetic branched polypeptides. II. J.Biol.Response Modifiers 5 (1986) 148–159.

    Google Scholar 

  48. Hudecz, F., Kajtár, J., Kurucz, I., Kovács, A.L., and Szekerke, M.: Investigation of the carrier function of polypeptides. Synthesis, conformation and cytotoxicity of oxazolone conjugates of poly(Lys) and poly[Lys-(DL-Alam )]. Makromol. Chem.. Macromol. Symp. 19 (1988) 107–124.

    CAS  Google Scholar 

  49. Arnold, L.J. Jr. Gutheil, I., and Kaplan, N.O.: Antineoplastic activity of poly(L-lysine) with some ascites tumor cells. Proc.Natl.Acad. Sci USA 76 (1979) 3246–3250.

    CAS  PubMed  Google Scholar 

  50. Chu, B.C.F.. and Howell, S.B.: Differential toxicity of carrier bound methotrexate toward human lymphocytes,marrow and tumor cells. Biochem Pharmocol. 30 (1981) 2545–2552.

    Article  CAS  Google Scholar 

  51. Rajnavolgyi, E., Hudecz, F., Mezo, G., Szekerke, M., and Gergely, J.: Isotype distribution and fine specificity of the antibody response of inbred mouse strains to four compounds belonging to a new group of synthetic branched polypeptides. Mol Immunol. 23 (1986) 27–37.

    Article  CAS  PubMed  Google Scholar 

  52. Gaal, D., Hudecz, F.. and Szekerke, M.: Immunomodulatory effect of synthetic branched polypeptides. I. .J. Biol. Response Modifiers 3 (1984) 174–184.

    CAS  Google Scholar 

  53. Bolton, A.E., and Hunter, W.M.: The labelling of proteins to high specific radioactivities by conjugation to a 125I-containing acylating agent. Biochem.J. 133 (1973) 529–538.

    CAS  PubMed  Google Scholar 

  54. Pimm, M.V., Gribben, S.J., Mezo, G., and Hudecz, F.: Strategies for labelling branched polypeptides with a poly(L-lysine) backbone with radioiodines (123I, 125I, 131I) and radiometals (111In, 51Cr) for biodistribution studies and radiopharmaceutical development. .J. Labelled Compounds 36 (1995) 157–172.

    CAS  Google Scholar 

  55. Pimm. M.V., Perkins, A.C., and Hudecz, F.: Scintigraphic evaluation of the pharmacokinetics of a soluble polymeric drug carrier. Eur.J. Nuclear Medicine 19 (1992) 449–452.

    CAS  Google Scholar 

  56. Pimm, M.V., Perkins, A.C., and Hudecz, F.: Gamma scintigraphy for evaluating the biodistribution of synthetic polymeric drug carriers. Nuclear Medicine Communications 13 (1992) 230–231.

    Google Scholar 

  57. Frier, M., Perkins, A.C., Pimm, M.V., and Hudecz, F.: Genetically engineered and synthetic macromolecules as radiopharmaceuticals with potential for liver, lung, blood pool and tumour imaging. Nuclear Medicine Communications 16 (1995) 240–241.

    Google Scholar 

  58. Perkins, A.C., Frier, M., Pimm, M.V., Hudecz, F., and Duncan, R.: Synthetic polymers as potential designer. Eur../. Nucl. Med. 23 (1996) 1134.

    Google Scholar 

  59. Perkins, A.C., Frier, M., Pimm, M.V., and Hudecz, F.: Tc99m-branched chain polypeptide (BCP): a potential synthetic radiopharmaceutical. J. Labelled Compounds 41 (1998) 631–638.

    CAS  Google Scholar 

  60. Hnatowich, D.J., Layne, W.W., Childs, R.L., Lanteigne, D., Davis, M.A., Griffin, T.W., and Doherty, P.W.: Radioactive labeling of antibody: a simple and efficient method. Science, 220 (1983) 613–615.

    CAS  PubMed  Google Scholar 

  61. Hudecz. F., Clegg, J.A., Kajtár, J., Embleton, M.J., Szekerke, M., and Baldwin, R.W.: Synthesis, conformation, biodistribution and in vitro cytotoxicity of daunomycin-branched polypeptide conjugates. Bioconjugate Chem. 3 (1992) 49–57.

    Article  CAS  Google Scholar 

  62. Hudecz, F., Clegg, J.A., Kajtir, J., Embleton, M.J., Pimm, M.V., Szekerke. M., and Baldwin, R.W.: Influence of carrier on biodistribution and in vitro cytotoxicity of methotrexate-branched polypeptide conjugates. Bioconjugate Chem. 4 (1993) 25–33.

    Article  CAS  Google Scholar 

  63. Mezo. G., Mezo, I., Seprodi, A., Teplán, I., Kovács, M., Vincze, B.. Pályi, I., Kajtár, J., Szekerke, M., and Hudecz. F.: Synthesis, conformation, biodistribution and hormon related in vitro anti-tumor effect of a GnRH antagonist-branched polypeptide conjugate. Bioconjugate Chem. 7 (1996) 642–650.

    Article  CAS  Google Scholar 

  64. Pimm, M.V.. Gribben, S.J., Bogd‡n, K., and Hudecz, F.: The effect of charge on the biodistribution in mice of branched polypeptides with poly(L-lysine) backbone labeled with 125I, 111In or 51Cr in mice. J Controlled Release 37 (1995) 161–172.

    Article  CAS  Google Scholar 

  65. Vincze, B.. Pdlyi, I., Daubner, D., Kdlnay, A., Mezo, G., Hudecz, F., Szekerke, M.. Teplán, I., and Mezo, I.: Antitumor effect of a GnRH antagonist and its conjugate on human breast cancer cells and their xenografts. .J. Cancer Res. Clin. Oncol. 120 (1994) 578–584.

    Article  CAS  PubMed  Google Scholar 

  66. Mezo, G., Mezó, I., Vincze, B., Kálnay, A., and Hudecz, F.: Synthesis and antitumour activity of new GnRH analogue-branched polypeptide conjugates. Cancer Detect.Prev. 22(S) (1998) 239–240

    Google Scholar 

  67. Pató, J., Ulbrich, K., Baker, P., Mezo, G., and Hudecz, F.: Synthesis of macromolecular conjugates of a urokinase inhibitor. J. Bioactive and Compatible Polymers 14 (1999) 99–121.

    Google Scholar 

  68. Mezó, G., Sármay, G., Hudecz, F., Kajtár, J., Nagy, Zs., Gergely, J., and Szekerke, M.: Synthesis and characterization of p-borono-Phe-branched polypeptide-monoclonal antibody ternary systems for potential use in boron neutron capture therapy (BNCT) J. Bioactive and Compatible Polymers 11 (1996) 263–285.

    Google Scholar 

  69. Gaál, D., and Hudecz, F.: Low toxicity and high antitumour activity of daunomycin by conjugation to immunpotential amphoteric branched polypeptide. Eur J. Cancer 34 (1998) 155–161

    PubMed  Google Scholar 

  70. Hudecz. F.: Alteration of immunogenicity and antibody recognition of B-cell epitopes by synthetic branched polypeptide carriers with poly[L-lysine Backbone. Biomed. Peptides, Proteins and Nucleic. Acids 1 (1995) 213–220.

    CAS  Google Scholar 

  71. Garcia, M., Nagy, I.B., Alsina, A., Mezo, G., Reig, F., Hudecz, F., and Haro, I.: Analysis of the interaction with biomembrane models of HAV-VP3(101–121) sequence conjugated to synthetic branched polypeptide carriers with poly[L-lysine] backbone. Langmuir 14 (1998) 1861–1869.

    Article  CAS  Google Scholar 

  72. Sospedra, P., Nagy, I.B., Haro, I., Mestres, C., Hudecz, F., and Reig, F.: Physicochemical behaviour of polylysine[HAV-VP3 peptide] constructs at the air-water interface. Langmuir 15 (1999) 5111–5117.

    CAS  Google Scholar 

  73. Nagy, I.B., Alsina, M.A.. Haro, I., Reig, F., and Hudecz, F.: Phospholipid — model membrane interactions with branched polypeptide conjugates of a hepatitis a virus peptide epitope. Bioconjugate Chemistry. 11 (2000) 30–38.

    Article  CAS  PubMed  Google Scholar 

  74. Hudecz, F., Hilbert, Á., Mezo, G., Mucsi, I., Kajtár, J. Bósze, Sz., Kurucz, I., and Rajnavolgyi, E. (1994) The use of branched polypeptide carrier based conjugates for the design of synthetic vaccine against HSV infection. in R. Epton (ed.) Innovation and Perspectives in Solid Phase Synthesis — Peptides, Polypeptides and Oligonucleotides — 1994 Intercept, Andover, pp. 315–320.

    Google Scholar 

  75. Hudecz, F., Hilbert, Á, Mezó, G., Kajtiir, J. and Rajnavolgyi, E.: B-cell epitopes in Herpes simplex Virus-(HSV-1) glycoprotein D (gD). In Synthetic peptides in the search for B-and T-cell epitopes. (Rajnavolgyi, E. ed.) R.G.Landes Company, Austin, pp. 157–169., 1994.

    Google Scholar 

  76. Venkataprasad, N., Coombes, A.G.A., Singh, M., Rhode, M., Wilkinson, K.A., Davies, S.S., Hudecz, F., and Vordermeier, M.H.: Resorbable lamellar subtrates of lactide polymers induce potent cellular immunity to an adsorbed mycobacterial antigen. Vaccine, 17 (1999) 1814–1819.

    Article  CAS  PubMed  Google Scholar 

  77. Wilkinson, K.A., Hudecz, F., Vordermeier, H.M., Ivanyi, J., and Wilkinson R.J.: Enhancement of the T cell response to a mycobacterial peptide by conjugation to synthetic branched polypeptide Eur. J.Immunol. 29 (1999) 2788–2796.

    Article  CAS  PubMed  Google Scholar 

  78. Wilkinson, K.A., Vordermeier, M.H., Wilkinson, R., Ivanyi, J. and Hudecz, F.: Synthesis and in vitro T cell immunogenicity of conjugates with dual specificities: attachment of epitope peptides of I6 kDa and 38 kDa proteins from M.tuberculosis to branched polypeptide. Bioconjugate Chem., 9 (1998) 539–547.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Research Group of Peptide Chemistry, Hungarian Academy of Science, Eötvös L.University, P.O. Box 32, Budapest 112, Hungary, H-1518

    F. Hudecz

Authors
  1. F. Hudecz
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

Copyright information

© 2002 Kluwer Academic Publishers

About this chapter

Cite this chapter

Hudecz, F. (2002). Design of Synthetic Branched Chain Polymeric Polypeptides for Targeting/Delivering Bioactive Molecules. In: Self-Assembling Peptide Systems in Biology, Medicine and Engineering. Springer, Dordrecht. https://doi.org/10.1007/0-306-46890-5_11

Download citation

  • DOI: https://doi.org/10.1007/0-306-46890-5_11

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-0-7923-7090-1

  • Online ISBN: 978-0-306-46890-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation