Conclusion
The immediate decrease in red cell dATP and increase in ADA activity post BMT, correlates with the contribution of the non-engrafted donor haematopoietic cells to clearing circulating dAdo by providing functional ADA activity. It has been established that erythrocyte precursors are not normally engrafted. Consequently, as these cells reach the end of their life span their contribution falls and a steady state is attained with red cell ADA falling to almost undetectable levels accompanied by a slight rise in dATP.
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© 2002 Kluwer Academic Publishers
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Fairbanks, L.D., Simmonds, H.A., Duley, J.A., Gaspar, H.B., Flood, T., Steward, C.A. (2002). ADA Activity and dATP Levels in Erythrocytes after Bone Marrow Transplantation. In: Zoref-Shani, E., Sperling, O. (eds) Purine and Pyrimidine Metabolism in Man X. Advances in Experimental Medicine and Biology, vol 486. Springer, Boston, MA. https://doi.org/10.1007/0-306-46843-3_10
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