Conclusion
The present study demonstrated that interactions of the thermosensitive polymer-modified liposomes with model membranes and cells were suppressed by the hydrated polymer chains attached to the liposome surface below the LCST. However, the hydrophilic-to-hydrophobic change of the tethered polymer chains above the LCST enhanced their interactions. As a result, efficient control of these interactions was achieved in response to ambient temperature. The information obtained in this study might be useful for the design of site-specific delivery systems for biologically active molecules, such as anti-cancer drugs, DNA, and oligonucleotides.
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Kono, K., Henmi, A., Nakai, R., Takagishi, T. (2002). Temperature-Control of Interactions of Thermosensitive Polymer Modified Liposomes with Model Membranes and Cells. In: Chiellini, E., Sunamoto, J., Migliaresi, C., Ottenbrite, R.M., Cohn, D. (eds) Biomedical Polymers and Polymer Therapeutics. Springer, Boston, MA. https://doi.org/10.1007/0-306-46842-5_20
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