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Interactions of Microbial Glycoconjugates with Collectins

Implications for Pulmonary Host Defense

  • Chapter
Glycomicrobiology

Conclusions

The surfactant-associated proteins, SP-A and SP-D, are members of a family of collagenous host defense lectins. There is increasing evidence that these pulmonary epithelial-derived proteins are important components of the innate immune response to microbial challenge. The lung collectins bind to glycoconjugates expressed by a wide variety of microorganisms in vitro. Such binding may cause microbial aggregation with resulting enhancement of mucociliary or leukocyte-mediated clearance. However, SP-A and SP-D also have the capacity to opsonize microorganisms with enhancement of phagocytosis and killing. Complementary or cooperative interactions between SP-A and SP-D and other lectins such as the macrophage mannose receptor could contribute to the efficiency of this defense system. Environmental or growth-phase-dependent modulation of glycoconjugates expressed on the surface of microorganisms could influence the mechanism or effectiveness of lectin-mediated clearance. Collectins may play particularly important roles in settings of inadequate or impaired specific immunity. Studies are needed to examine the possibility that acquired deficiencies of the lung collectins in certain hospitalized patients may render them susceptible to pathogens that otherwise are harmless to healthy individuals.

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References

  • Aarson, G. L., 1996, Lectins as defence molecules in vertebrates and invertebrates, Fish Shellfish Immunol. 6:277–289.

    Google Scholar 

  • Aderibigbe, A. O., Thomas, R. F., Mercer, R. R., Auten, R. L., 1999, Briefexposure to 95% oxygen alters surfactant protein D and mRNA in adult rat alveolar and bronchiolar epithelium, Am. J. Respir. Cell Mol Biol. 20:219–227.

    PubMed  CAS  Google Scholar 

  • Athamna, A., Ofek, I., Keisari, Y, Markowitz, S., Dutton, G. S., and Sharon, N., 1998, Lectinophagocytosis of encapsulated Klebsiella pneumoniae mediated by surface lectin of guinea pig alveolar macrophages and human-monocyte-derived macro-phages, Infect. Immun. 59:1673–1682.

    Google Scholar 

  • Blau, H., Riklis, S., Kravtsov, V., and Kalina, M., 1994, Secretion of cytokines by rat alveolar epithelial cells: Possible regulatory role for SP-A, Am. J. Physiol. 266:Pt1:L1L148–155.

    Google Scholar 

  • Brown-Augsburger, P., Hartshorn, K., Chang, D., Rust, K., Fliszar, C., Welgus, H. G., and Crouch, E. C. 1996, Site-directed mutagenesis of Cys-15 and Cys-20 of pulmonary surfactant protein D. Expression of a trimeric protein with altered anti-viral properties, J. Biol. Chem. 271:13724–13730.

    PubMed  CAS  Google Scholar 

  • Caton, A., Brownlee, G., Yewdell, J., and Gerhard, W., 1982, The antigenic structure of influenza virus A/PR/8/34 hemagglutinin (H1 subtype), Cell 31:417–427.

    PubMed  CAS  Google Scholar 

  • Chroneos, Z., and Shepherd, V. L., 1995, Differential regulation of the mannose and SP-A receptors on macrophages, Am. J. Physiol. 269:L721–726.

    PubMed  CAS  Google Scholar 

  • Chroneos, Z. C., Abdolrasulnia, R., Whitsett, J. A., Rice, W. R., and Shepherd, V. L., 1996, Purification of a cell-surface receptor for surfactant protein A, J. Biol. Chem. 271:16375–16383.

    PubMed  CAS  Google Scholar 

  • Crawford, S. W., Mecham, R. P., and Sage, H., 1986, Structural characteristics and inter-molecular organization of human pulmonary-surfactant-associated proteins, Biochem. J. 240:107–114.

    PubMed  CAS  Google Scholar 

  • Crouch, E. C., 1998, Collectins and pulmonary host defense, Am. J. Respir. Cell Mol. Biol. 19:177–201.

    PubMed  CAS  Google Scholar 

  • Crouch, E., Persson, A., Chang, D., and Parghi, D., 1991, Surfactant protein D. Increased accumulation in silica-induced pulmonary lipoproteinosis, Am. J. Pathol. 139:765–776.

    PubMed  CAS  Google Scholar 

  • Crouch, E., Persson, A., Chang, D., and Heuser, J., 1994a, Molecular structure of pulmonary surfactant protein D (SP-D), J. Biol. Chem. 269:17311–17319.

    PubMed  CAS  Google Scholar 

  • Crouch, E., Chang, D., Rust, K., Persson, A., and Heuser, J., 1994b, Recombinant pulmonary surfactant protein D. Post-translational modification and molecular assembly, J. Biol. Chem. 269:15808–15813.

    PubMed  CAS  Google Scholar 

  • Crouch, E. C., Persson, A., Griffin, G. L., Chang, D., and Senior, R. M., 1995, Interactions of pulmonary surfactant protein D (SP-D) with human blood leukocytes, Am. J. Respir. Cell Mol. Biol. 12:410–415.

    PubMed  CAS  Google Scholar 

  • Drickamer, K., and McCreary, V., 1987, Exon structure of a mannose-binding protein gene reflects its evolutionary relationship to the asialoglycoprotein receptor and nonfibrillar collagens, J. Biol. Chem. 262:2582–2589.

    PubMed  CAS  Google Scholar 

  • Eggleton, P., Ghebrehiwet, B., Sastry, K. N., Coburn, J. P., Zaner, K. S., Reid, K. B., and Tauber, A. I., 1995, Identification of a gC1q-binding protein (gC1q-R) on the surface of human neutrophils. Subcelluiar localization and binding properties in comparison with the cC1q-R, J. Clin. Invest. 95:1569–1578.

    PubMed  CAS  Google Scholar 

  • Gaynor, C. D., McCormack, F. X., Voelker, D. R., McGowan, S. E., and Schlesinger, L. S., 1995, Pulmonary surfactant protein A mediates enhanced phagocytosis of Mycobacterium tuber culosis by a direct interaction with human macrophages, J. Immunol. 155:5343–5351.

    PubMed  CAS  Google Scholar 

  • Haas, C., Voss, T., and Engel, J., 1991, Assembly and disulfide rearrangement of recombinant surfactant protein A in vitro. Eur. J. Biochem. 197:799–803.

    PubMed  CAS  Google Scholar 

  • Haller, E. M., Shelley, S. A., Montgomery, M. R., and Balis, J. U., 1992, Immunocyto-chemical localization of lysozyme and surfactant protein A in rat type II cells and extracellular surfactant forms, J. Histochem. Cytochem. 40:1491–1500.

    PubMed  CAS  Google Scholar 

  • Hartshorn, K. L., Sastry, K., Brown, D., White, M. R., Okarma, T. B., Lee, Y. M., and Tauber, A. I., 1993a, Conglutinin acts as an opsonin for influenza A viruses, J. Immunol. 151:6265–6273.

    PubMed  CAS  Google Scholar 

  • Hartshorn, K. L., Sastry, K., White, M. R., Anders, E. M., Super, M., Ezekowitz, R. A., and Tauber, A. I., 1993b, Human mannose-binding protein functions as an opsonin for influenza A viruses, J. Clin. Invest. 91:1414–1420.

    PubMed  CAS  Google Scholar 

  • Hartshorn, K. L., Crouch, E. C., White, M. R., Eggleton, P., Tauber, A. I., Chang, D., and Sastry, K., 1994, Evidence for a protective role of pulmonary surfactant protein D (SP-D) against influenza A viruses, J. Clin. Invest. 94:311–319.

    PubMed  CAS  Google Scholar 

  • Hartshorn, K., Chang, D., Rust, K., and Crouch, E. C., 1996a, Interactions of recombinant human pulmonary surfactant protein D and SP-D multimers with influenza A, Am. J. Physiol. (Lung Cell. Mol. Physiol.) 271:L753–L762

    CAS  Google Scholar 

  • Hartshorn, K. L., Reid, K. B., White, M. R., Jensenius, J. C., Morris, S. M., Tauber, A. I., and Crouch, E., 1996b, Neutrophil deactivation by influenza A viruses: Mechanisms of protection after viral opsonization with collectins and hemagglutination-inhibiting antibodies, Blood 87:3450–3461.

    PubMed  CAS  Google Scholar 

  • Hartshorn, K. L., Crouch, E., White, M. R., Colamussi, M. I., Kakkanatt, A., Tauber, B., Shepherd, V., and Sastry, K., 1998, Pulmonary surfactant proteins A and D enhance neutrophil uptake of bacteria, Am. J. Physiol. 274:L958–L969.

    PubMed  CAS  Google Scholar 

  • Hattori, A., Kuroki, Y., Katoh, T., Takahashi, H., Shen, H. Q., Suzuki, Y., and Akino, T., 1996a, Surfactant protein A accumulating in the alveoli of patients with pulmonary alveolar proteinosis-Oligomeric structure and interaction with lipids, Am. J. Respir. Cell Mol. Biol. 14:608–619.

    PubMed  CAS  Google Scholar 

  • Hattori, A., Kuroki, Y., Sohma, H., Ogasawara, Y., and Akino, T., 1996b, Human surfactant protein A with two distinct oligomeric structures which exhibit different capacities to interact with alveolar type II cells, Biochem. J. 317:939–944.

    PubMed  CAS  Google Scholar 

  • Hickling, T. P., Malhotra, R., and Sim, R. B. 1998, Human lung surfactant protein A exists in several different oligomeric states: Oligomer size distribution varies between patient groups, Mol. Med. 4:266–275.

    PubMed  CAS  Google Scholar 

  • Holmskov, U., and Jensenius, J. C., 1993, Structure and function of collectins: Humoral C-type lectins with collagenous regions, Behring Inst. Mitt. 93:224–235.

    PubMed  CAS  Google Scholar 

  • Holmskov, U., Malhotra, R., Sim, R. B., and Jensenius, J. C., 1994, Collectins: Collagenous C-typelectins of the innate immune defense system, Immunol. Today 15:67–74.

    PubMed  CAS  Google Scholar 

  • Holmskov, U., Laursen, S. B., Malhotra, R., Wiedemann, H., Timpl, R., Stuart, G. R., Tornoe, I., Madsen, P. S., Reid, K. B., and Jensenius, J. C., 1995, Comparative study of the structural and functional properties of a bovine plasma C-type lectin, collectin-43, with other collectins, Biochem. J. 305:889–896.

    PubMed  CAS  Google Scholar 

  • Holmskov, U., Lawson, P., Teisner, B., Tornoe, I., Willis, A. C., Morgan, C., Koch, C., and Reid, K. B. M., 1997, Isolation and characterization of a new member of the scavenger receptor superfamily, glycoprotein-340 (gp-340), as a lung surfactant protein-D binding molecule, J. Biol. Chem. 272:13743–13749.

    PubMed  CAS  Google Scholar 

  • Honda, Y., Takshashi, H., Kuroki, Y., Akino, T., and Abe, S., 1996, Decreased contents of surfactant proteins A and D in BAL fluids of healthy smokers, Chest 109:1006–1009.

    PubMed  CAS  Google Scholar 

  • Hoppe, H. J., and Reid, K. B., 1994a, Collectins-Soluble proteins containing collagenous regions and lectin domains-and their roles in innate immunity, Protein Sci. 3:1143–1158.

    Article  PubMed  CAS  Google Scholar 

  • Hoppe, H. J., and Reid, K. B., 1994b, Trimeric C-type lectin domains in host defence, Structure 2:1129–1133.

    PubMed  CAS  Google Scholar 

  • Horowitz, S., Watkins, R. H., Auten, R. L., Jr., Mercier, C. E., and Cheng, E. R., 1991, Differential accumulation of surfactant protein A, B, and C mRNAs in two epithelial cell types of hyperoxic lung, Am. J. Respir. Cell Mol. Biol. 5:511–515.

    PubMed  CAS  Google Scholar 

  • Ikegami, M., Korhagen, T. R., Bruno, M. D., Whitsett, J. A., and Jobe, A. H., 1997, Surfactant metabolism in surfactant protein A-deficient mice, Am. J. Physiol. (Lung Cell. Mol. Physiol.) 272:L479–L485.

    CAS  Google Scholar 

  • Kabha, K., Schmegner, J., Keisari, Y, Parolis, H., Schlepper-Schaefer, J., and Ofek, L, 1997, SP-A enhances phagocytosis of Klebsiella by interaction with capsular polysaccharides and alveolar macrophages, Am. J. Physiol. (Lung Cell. Mol. Physiol.) 272:L344–L352.

    CAS  Google Scholar 

  • Kalina, M., Blau, H., Riklis, S., and Kravtsov, V, 1995, Interaction of surfactant protein A with bacterial lipopolysaccharide may affect some biological functions, Am. J. Physiol. 268:L144–151.

    PubMed  CAS  Google Scholar 

  • Kasper, M., Albrecht, S., Grossmann, H., Grosser, M., Schuh, D., and Muller, M., 1995, Monoclonal antibodies to surfactant protein D: Evaluation of immunoreactivity in normal rat lung and in a radiation-induced fibrosis model, Exp. Lung Res. 21:577–588.

    Article  PubMed  CAS  Google Scholar 

  • Kishore, U., Wang, J. Y, Hoppe, H. J., and Reid, K. B. M., 1996, The alpha-helical neck region of human surfactant protein D is essential for the binding of the carbohydrate recognition domains to lipopolysaccharides and phospholipids, Biochem. J. 318:505–511.

    PubMed  CAS  Google Scholar 

  • Korfhagen, T. R., Bruno, M. D., Ross, G. E, Huelsman, K. M., Ikegami, M., Jobe, A. H., Wert, S. E., Stripp, B. R., Morris, R. E., Glasser, S. W., Bachurski, C. J., Iwamoto, H. S., and Whitsett, J. A., 1996, Altered surfactant function and structure in SP-A gene targeted mice, Proc. Natl. Acad. Sci. U.S.A. 93:9594–9599.

    PubMed  CAS  Google Scholar 

  • Kuan, S. F., Rust, K., and Crouch, E., 1992, Interactions of surfactant protein D with bacterial lipopolysaccharides. Surfactant protein D is an Escherichia coli-binding protein in bronchoalveolar lavage, J. Clin. Invest. 90:97–106.

    PubMed  CAS  Google Scholar 

  • Kuan, S. F., Persson, A., Parghi, D., and Crouch, E., 1994, Lectin-mediated interactions of surfactant protein D with alveolar macrophages, Am. J. Respir. Cell Mol. Biol. 10:430–436.

    PubMed  CAS  Google Scholar 

  • Kuroki, Y, Gasa, S., Ogasawara, Y, Shiratori, M., Makita, A., and Akino, T., 1992, Binding specificity of lung surfactant protein SP-D for glucosylceramide, Biochem. Biophys. Res. Commun. 187:963–969.

    PubMed  CAS  Google Scholar 

  • Kuroki, Y., Mason, R. J., and Voelker, D. R., 1988, Alveolar type II cells express a high-affinity receptor for pulmonary surfactant protein A, Proc. Natl. Acad. Sci. USA 85:5566–5570.

    PubMed  CAS  Google Scholar 

  • LeVine, A. M., Bruno, M., Whitsett, J., and Korfhagen, T. R., 1997, Surfactant protein-A in pulmonary host defense against bacterial pathogens in vivo, Am. J. Respir. Cell Mol. Biol. 155:A214.

    Google Scholar 

  • Lim, B. L., Wang, J. Y., Holmskov, U., Hoppe, H. J., and Reid, K. B., 1994, Expression of the carbohydrate recognition domain of lung surfactant protein D and demonstration of its binding to lipopolysaccharides of gram-negative bacteria, Biochem. Biophys. Res. Commun. 202:1674–1680.

    PubMed  CAS  Google Scholar 

  • Limper, A. H., O’Riordan, D. M., Vuk-Pavlovic, Z., and Crouch, E. C., 1994, Accumulation of surfactant protein D in the lung during Pneumocystis carinii pneumonia, J. Euk. Microbiol. 41:S98.

    Google Scholar 

  • Limper, A. H., Crouch, E. C., O’Riordan, D. M., Chang, D., Vuk-Pavlovic, Z., Standing, J. E., Kwon, K. Y, and Adlakha, A., 1995, Surfactant protein D modulates interaction of Pneumocystis carinii with alveolar macrophages, J. Lab. Clin. Med. 126:416–422.

    PubMed  CAS  Google Scholar 

  • Lu, J., Willis, A. C., and Reid, K. B., 1992, Purification, characterization and cDNA cloning of human lung surfactant protein D, Biochem, J. 284:795–802.

    CAS  Google Scholar 

  • Lu, J., Wiedemann, H., Holmskov, U., Thiel, S., Timpl, R., and Reid, K. B., 1993, Structural similarity between lung surfactant protein D and conglutinin. Two distinct, C-type lectins containing collagen-like sequences, Eur. J. Biochem. 215:793–799.

    PubMed  CAS  Google Scholar 

  • Madan, T., Eggleton, P., Kishore, U., Strong, P., Aggrawal, S. S., Sarma, P. U., and Reid, K. B. M., 1997, Binding of pulmonary surfactant proteins A and D to Aspergillus fumigatus conidia enhances phagocytosis and killing by human neutrophils and aleveolar macrophages, Infect. Immun. 65:3171–3179.

    PubMed  CAS  Google Scholar 

  • Malhotra, R., and Sim, R. B., 1995, Collectins and viral infection, Trends Microbiol. 3:240–244.

    PubMed  CAS  Google Scholar 

  • Malhotra, R., Thiel, S., Reid, K. B., and Sim, R. B., 1990, Human leukocyte C1q receptor binds other soluble proteins with collagen domains, J. Exp. Med. 172:955–959.

    PubMed  CAS  Google Scholar 

  • Malhotra, R., Haurum, J., Thiel, S., and Sim, R. B., 1992, Interaction of C1q receptor with lung surfactant protein A, Eur. J. Immunol. 22:1437–1445.

    PubMed  CAS  Google Scholar 

  • Malhotra, R., Haurum, J., Thiel, S., Jensenius, J. C., and Sim, R. B., 1993, Pollen grains bind to lung alveolar type II cells (A549) via lung surfactant protein A (SP-A), Biosci. Rep. 13:79–90.

    PubMed  CAS  Google Scholar 

  • Malhotra, R., Haurum, J. S., Thiel, S., and Sim, R. B., 1994, Binding of human collectins (SP-A and MBP) to influenza virus, Biochem. J. 304:455–461.

    PubMed  CAS  Google Scholar 

  • Manz-Keinke, H., Egenhofer, C., Plattner, H., and Schlepper-Schafer, J., 1991, Specific interaction of lung surfactant protein A (SP-A) with rat alveolar macrophages, Exp. Cell Res. 192:597–603.

    PubMed  CAS  Google Scholar 

  • McGroarty, E. J., and Rivera, M., 1990, Growth-dependent alterations in production of serotype-specific and common antigen lipopolysaccharides in Pseudomonas aeruginosa PAO1. Infect. Immun. 58:1030–1037.

    PubMed  CAS  Google Scholar 

  • McIntosh, J. C., Swyers, A. H., Fisher, J. H., and Wright, J. R., 1996, Surfactant proteins A and D increase in response to intratracheal lipopolysaccharide, Am. J. Respir. Cell Mol. Biol. 15:509–519.

    PubMed  CAS  Google Scholar 

  • McNeely, T. B., and Coonrod, J. D., 1993, Comparison of the opsonic activity of human surfactant protein A for Staphylococcus aureus and Streptococcus pneumoniae with rabbit and human macrophages, J. Infect. Dis. 167:91–97.

    PubMed  CAS  Google Scholar 

  • Miyamura, K., Leigh, L. E., Lu, J., Hopkin, J., Lopez Bernal, A., and Reid, K. B., 1994, Surfactant protein D binding to alveolar macrophages, Biochem. J. 300:237–242.

    PubMed  CAS  Google Scholar 

  • Nogee, L. M, Wispe, J. R., Clark, J. C., and Whitsett, J. A., 1989, Increased synthesis and mRNA of surfactant protein A in oxygen-exposed rats, Am. J. Respir. Cell Mol. Biol. 1:119–125.

    PubMed  CAS  Google Scholar 

  • Ofek, I., and Doyle, J. D., 1994, Bacterial Adhesion to Cells and Tissues, Chapman and Hall, New York.

    Google Scholar 

  • Ofek, I., Goldhar, J., Keisari, Y., and Sharon, N., 1995, Nonopsonic phagocytosis of microorganisms, Annu. Rev. Microbiol. 49:239–276.

    PubMed  CAS  Google Scholar 

  • Ofek, I., Kabha, K., Keisari, Y, Schlepper-Schaefer, J., Abraham, S. N., McGregor, D., Chang, D., and Crouch, E., 1997, Recognition of Klebsiellapneumoniae by pulmonary C-type lectins, Nova Acta Leopold NF 75:43–54.

    CAS  Google Scholar 

  • O’Riordan, D. M., Standing, J. E., Kwon, K.-Y, Crouch, E. C., and Limper, A. H., 1995, Surfactant protein D interacts with Pneumocystis carinii and mediates organism adherence to alveolar macrophages, J. Clin. Invest. 95:2699–2710.

    Google Scholar 

  • Persson, A., Chang, D., Rust, K., Moxley, M., Longmore, W., and Crouch, E., 1989, Purification and biochemical characterization of CP4 (SP-D), a collagenous surfactant-associated protein, Biochemistry 28:6361–6367.

    PubMed  CAS  Google Scholar 

  • Persson, A., Chang, D., and Crouch, E., 1990, Surfactant protein D is a divalent cation-dependent carbohydrate-binding protein, J. Biol. Chem. 265:5755–5760.

    PubMed  CAS  Google Scholar 

  • Pikaar, J. C., van Golde, L. M. G., van Strijp, J. A. G., and Van Iwaarden, J. E, 1995, Opsonic activities of surfactant proteins A and D in phagocytosis of gram-negative bacteria by alveolar macrophages, J. Infect. Dis. 72:481–489.

    Google Scholar 

  • Podschun, R., Sievers, D., Fischer, A., and Ullmann, U., 1993, Serotypes, hemagglutinins, siderophore synthesis, and serum resistance of Klebsiella isolates causing human urinary tract infections, J. Infect. Dis. b68:1415–1421.

    Google Scholar 

  • Polotsky, V. Y., Fischer, W., Ezekowitz, R. A., and Joiner, K. A., 1996, Interactions of human mannose-binding protein with lipoteichoic acids, Infect. Immun. 64:380–383.

    PubMed  CAS  Google Scholar 

  • Reading, P. C., Morey, L. S., Crouch, E. C., and Anders, E. M., 1997, Collectin-mediated antiviral host defence of the lung: Evidence from influenza virus infection of mice, J. Virol. 71:8204–8212.

    PubMed  CAS  Google Scholar 

  • Ross, G. F., Ohning, B. L., Tannenbaum, D., and Whitsett, J. A., 1987, Structural relationships of the major glycoproteins from human alveolar proteinosis surfactant, Biochim. Biophys. Acta 911:294–305.

    PubMed  CAS  Google Scholar 

  • Rust, K., Grosso, L., Zhang, V., Chang, D., Persson, A., Longmore, W., Cai, G. Z., and Crouch, E., 1991, Human surfactant protein D: SP-D contains a C-type lectin carbo-hydrate recognition domain, Arch. Biochem. Biophys. 290:116–126.

    PubMed  CAS  Google Scholar 

  • Sahly, H., and Podschun, R., 1997, Clinical, bacteriological, and serological aspects of Klebsiella infections and their spondylarthropathic sequelae. Clin. Diag. Lab. Immunol 4:393–399.

    CAS  Google Scholar 

  • Sano, K., Fisher, J., Mason, R. J., Kuroki, Y, Schilling, J., Benson, B., and Voelker, D., 1987, Isolation and sequence of a cDNA clone for the rat pulmonary surfactant-associated protein (PSP-A), Biochem. Biophys. Res. Commun. 144:367–374.

    PubMed  CAS  Google Scholar 

  • Schelenz, S., Malhotra, R., Sim, R. B., Holmskov, U., and Bancroft, G. J., 1995, Binding of host collectins to the pathogenic yeast Cryptococcus neoformans: Human surfactant protein D acts as an agglutinin for acapsular yeast cells, Infect. Immun. 63:3360–3366.

    PubMed  CAS  Google Scholar 

  • Shimizu, H., Fisher, J. H., Papst, P., Benson, B., Lau, K., Mason, R. J., and Voelker, D. R., 1992, Primary structure of rat pulmonary surfactant protein D. cDNA and deduced amino acid sequence, J. Biol. Chem. 267:1853–1857.

    PubMed  CAS  Google Scholar 

  • Tarkkanen, A. M., Allen, B. L., Williams, P. H., Kauppi, M., Haahtela, K., Siitonen, Orskov, I., Orskov, F., Clegg, S., and Korhonen, T. K., 1992, Fimbriation, capsulation, and iron-scavenging systems of Klebsiella strains associated with human urinary tract infection, Infect. Immun. 60:1187–1192.

    PubMed  CAS  Google Scholar 

  • Van Iwaarden, J. F., Pikaar, J. C., Storm, J., Brouwer, E., Verhoef, J., Oosting, R. S., Van Golde, L. M., and Van Strijp, J. A., 1994, Binding of surfactant protein A to the lipid A moiety of bacterial lipopolysaccharides, Biochem. J. 303:407–411.

    PubMed  Google Scholar 

  • Viviano, C. J., Bakewell, W. E., Dixon, D., Dethloff, L. A., and Hook, G. E., 1995, Altered regulation of surfactant phospholipid and protein A during acute pulmonary inflammation, Biochim. Biophys. Acta 1259:235–244.

    PubMed  Google Scholar 

  • Voorhout, W. F., Veenendaal, T., Haagsman, H. P., Verkleij, A. J., Van Golde, G. L. M., and Geuze, H. J., 1991, Surfactant protein A is localized at the corners of the pulmonary tubular myelin lattice, J. Histochem. Cytochem. 39:1331–1336.

    PubMed  CAS  Google Scholar 

  • Voss, T., Melchers, K., Scheirle, G., and Schafer, K. P., 1991, Structural comparison of recombinant pulmonary surfactant protein SP-A derived from two human coding sequences: Implications for the chain composition of natural human SP-A, Am. J. Respir. Cell Mol. Biol. 4:88–94.

    PubMed  CAS  Google Scholar 

  • Voss, T., Schafer, K. P., Nielsen, P. F., Schafer, A., Maier, C., Hannappel, E., Maassen, J., Landis, B., Klemm, K., and Przybylski, M., 1992, Primary structure differences of human surfactant-associated proteins isolated from normal and proteinosis lung, Biochim. Biophys. Acta 1138:261–267.

    PubMed  CAS  Google Scholar 

  • Vuk-Pavlovic, Z., Diaz-Montes, T., Standing, J. E., and Limper, A. H., 1998, Surfactant protein-D binds to cell wall β-glucans, Am. J. Respir. Cell Mol. Biol. 157:A236.

    Google Scholar 

  • Wang, J. Y, Kishore, U., Lim, B. L., Strong, P., and Reid, K. B. M., 1996, Interaction of human lung surfactant proteins A and D with mite (Dermatophagoides pteronyssinus) allergens, Clin. Exp. Immunol. 106:367–373.

    PubMed  CAS  Google Scholar 

  • Weiss, J., Hutzler, M., and Kao, L., 1986, Environmental modulation of lipopolysaccharide chain length alters the sensitivity of Escherichia coli to the neutrophil bactericidal/permeability-increasing protein, Infect. Immunol. 51:594–599.

    CAS  Google Scholar 

  • Williams, M. D., Wright, J. R., March, K. L., and Martin, W. J., 1996, Human surfactant protein A enhances attachment of Pneumocystis carinii to rat alveolar macrophages, Am. J. Respir. Cell Mol. Biol. 14:232–238.

    PubMed  CAS  Google Scholar 

  • Wintergerst, E., Manz-Keinke, H., Plattner, H., and Schlepper-Schafer, J., 1989, The interaction of a lung surfactant protein (SP-A) with macrophages is mannose dependent, Eur. J. Cell Biol. 50:291–298.

    PubMed  CAS  Google Scholar 

  • Zimmerman, P. E., Voelker, D. R., McCormack, F. X., Paulsrud, J. R., and Martin, W. J., 1992, 120-kD surface glycoprotein of Pneumocystis carinii is a ligand for surfactant protein A, J. Clin. Invest. 89:143–149.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Human Microbiology, Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, 69978, Israel

    Itzhak Ofek

  2. Department of Pathology, Washington University School of Medicine, St Louis, Missouri, 63101

    Erika Crouch

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  1. University of Louisville, Louisville, Kentucky

    Ron J. Doyle

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© 2002 Kluwer Academic Publishers

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Ofek, I., Crouch, E. (2002). Interactions of Microbial Glycoconjugates with Collectins. In: Doyle, R.J. (eds) Glycomicrobiology. Springer, Boston, MA. https://doi.org/10.1007/0-306-46821-2_18

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  • DOI: https://doi.org/10.1007/0-306-46821-2_18

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-306-46239-9

  • Online ISBN: 978-0-306-46821-6

  • eBook Packages: Springer Book Archive

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