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Kaposi’s Sarcoma-Associated Herpesvirus (KSHV/HHV8) and the Etiology of KS

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Herpesviruses and Immunity

Part of the book series: Infectious Agents and Pathogenesis ((IAPA))

Conclusion

New molecular techniques now play a tremendous role in the field of emerging infectious disease, as evidenced by the discovery of KSHV in 1994. Within only two years the entire genome of this new human herpesvirus was sequenced. Although initial studies were inconclusive about the role of KSHV in KS, the accumulation of more methodologically sound studies provides strong evidence of the causal association. Other noninfectious cofactors are certain to contribute to KS pathogenesis, however, as the current epidemiological evidence demonstrates KSHV is almost certainly the causative infectious agent for KS.

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References

  1. Chang, Y., Cesarman, E., Pessin, M. S. et al., 1994, Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi’s sarcoma, Science 265: 1865–1869.

    Google Scholar 

  2. Lisitsyn, N. A., Lisitsina, N. M., Dalbagni, G. et al., 1995 Comparative genomic analysis of tumors: Detection of DNA losses and amplification, Proc Natl. Acad. Sci USA 92(1):151–155.

    PubMed  CAS  Google Scholar 

  3. Moore, P. S., Gao, S.-J., Dominguez, G. et al., 1996, Primary characterization of a herpesvirus-like agent associated with Kaposi’s sarcoma, J Virol. 70:549–558.

    PubMed  CAS  Google Scholar 

  4. Roizman, B., 1993, The family Herpesviridae, in: The Family Herpesviridae, (B. Roizman, R. J. Whitley, and C. Lopez, eds.), Raven Press, New York, pp. 1–9.

    Google Scholar 

  5. Cohen, J., 1994, Controversy: Is KS really caused by new herpesvirus?, Science 268:1847–1848.

    Google Scholar 

  6. Levy, J. A., 1995, A new human herpesvirus: KSHV or HHV8?, Lancet 346:786.

    PubMed  CAS  Google Scholar 

  7. Anonymous, 1994, Addressing emerging infectious disease threats: A prevention stategy for the United States. Executive Summary, MMWR 43(RR-5): 1–18.

    Google Scholar 

  8. Gao, S.-J., Moore, P. S., 1996, Molecular identification of unculturable infectious agents, Emerging Infect. Dir. 2:159–167.

    CAS  Google Scholar 

  9. Tappero, J. W., Conant, M. A., Wolfe, S. F., and Berger, T. G., 1993, Kaposi’s sarcoma: Epidemiology, pathogenesis, histology, clinical spectrum, staging criteria and therapy, ℑ Am. Acad. Dermtatol. 28:371–395.

    CAS  Google Scholar 

  10. Oettle, A. G. (ed.), 1962, Geographic and Racial Differences in the Frequency of Kaposi’s Sarcomaas Evidence of Environmental or Genetic Causes, Karger, Basel, p. 18.

    Google Scholar 

  11. Giraldo, G., Beth, E., and Haguenau, F., 1972, Herpes-type particles in tissue culture of Kaposi’s sarcoma from different geographic regions. ℑ Natl. Cancer Inst. 49: 1509–1526.

    CAS  Google Scholar 

  12. Beral, V., Peterman, T. A., Berkelman, R. L., and Jaffe, H. W., 1990, Kaposi’s sarcoma among persons with AIDS: A sexually transmitted infection?, Lancet 335: 123–128.

    Article  PubMed  CAS  Google Scholar 

  13. Beral, V., Bull, D., Jaffe, H. et al., 1991, Is risk of Kaposi’s sarcoma in AIDS patients in Britain increased if sexual partners came from United States or Africa?, BM ℑ 302:624–625.

    CAS  Google Scholar 

  14. Beral, V., 1991, Epidemiology of Kaposi’s sarcoma, in: Epidemiology Of Kaposi’s Sarcoma, Vol. 10, Imperial Cancer Research Fund, London, pp. 5–22.

    Google Scholar 

  15. Beral, V., Bull, D., Darby, S. et al., 1992, Risk of Kaposi’s sarcoma and sexual practices associated with faecal contact in homosexual or bisexual men with AIDS, Lancet 339:632–636.

    Article  PubMed  CAS  Google Scholar 

  16. Archibald, C. P., Schechter, M. T., Le, T. N., Craib, K. J. P., Montaner, J. S. G., and O’Shaughnessy, M. V., 1992, Evidence for a sexually transmitted cofactor for AIDS-related Kaposi’s sarcoma in a cohort of homosexual men, Epidemiology 3:203–209.

    PubMed  CAS  Google Scholar 

  17. Hoover, D. R., Black, C., Jacobson, L. P. et al., 1993, Epidemiologic analysis of Kaposi’s sarcoma as an early and later AIDS outcome in homosexual men. Am. ℑ Epidemiol. 138:266–278.

    CAS  Google Scholar 

  18. Albrecht, H., Helm, E. B., Plettenberg, A. et al., 1994, Kaposi’s sarcoma in HIV infected women in Germany: More evidence for sexual transmission. A report of 10 cases and review of the literature [Review], Genitourinary Med. 70(6):394–398.

    CAS  Google Scholar 

  19. Armenian, H. K., Hoover, D. R., Rubb, S. et al., 1993, Composite risk score for Kaposi’s sarcoma based on a case-control and longitudinal study in the Multicenter AIDS Cohort Study (MACS) population, Am. ℑ Epidemiol. 138:256–265.

    CAS  Google Scholar 

  20. Archibald, C. P., Schechter, M. T., Craib, K. J. et al., 1990, Risk factors for Kaposi’s sarcoma in the Vancouver Lymphadenopathy-AIDS Study, ℑ AIDS 3(suppl):S 18–23.

    Google Scholar 

  21. Schechter, M. T., Marion, S. A., Elmslie, K. D., Ricketts, M. N., Nault, P., and Archibald, C. P., 1991, Geographic and birth cohort associations of Kaposi’s sarcoma among homosexual men in Canada, Am. ℑ Epidemiol. 134:485–488.

    CAS  Google Scholar 

  22. Duesberg, P., 1988, HIV is not the cause of AIDS, Science 241:514–517.

    PubMed  CAS  Google Scholar 

  23. Cohen, J., 1994, Could drugs, rather than a virus, be the cause of AIDS?, Science 266:1648–1649.

    PubMed  CAS  Google Scholar 

  24. Evans, A. S., 1978, Causation and disease: A chronological journey, Am. ℑ Epidemiol 108:249–258.

    CAS  Google Scholar 

  25. Fredericks, D. N., and Relman, D. A., 1996, Sequence-based identification of microbial pathogens: A reconsideration of Koch’s postulates, Clin. Microbiol. Rev. 9: 18–33.

    PubMed  CAS  Google Scholar 

  26. Hill, A. B., 1965, Environment and disease: Association or causation?, Proc. R. Soc. Med. 58:295–300.

    PubMed  CAS  Google Scholar 

  27. Schlesselman, J. J,, 1982, Case Control Studies: Design, Conduct Analysis, Oxford University Press, New York.

    Google Scholar 

  28. Susser, M., 1977, Judgment and causal inference: Criteria in epidemiologic studies, Am. ℑ Epidemiol. 105:1–15.

    CAS  Google Scholar 

  29. Parry, J. P., and Moore, P. S., 1997, Corrected prevalence of Kaposi’s sarcoma (KS)-associated herpesvirus infection prior to onset of KS, AIDS 11:127–128.

    PubMed  CAS  Google Scholar 

  30. Rothman, K. J., 1986, Modem Epidemiology, Little, Brown, Boston.

    Google Scholar 

  31. Dupin, N., Grandadam, M., Calvez, V. et al., 1995, Herpesvirus-like DNA in patients with Mediterranean Kaposi’s sarcoma, Lancet 345:761–762.

    Article  PubMed  CAS  Google Scholar 

  32. Ambroziak, J. A., Blackbourn, D. J., Herndier, B. G. et al., 1995, Herpes-like sequences in HIV-infected and uninfected Kaposi’s sarcoma patients. Science 268:582–583.

    PubMed  CAS  Google Scholar 

  33. Lebbé, C., de Crémoux, P., Rybojad, M., Costa da Cunha, C., Morel, P., and Calvo, F., 1995, Kaposi’s sarcoma and new herpesvirus, Lancet 345: 1180.

    PubMed  Google Scholar 

  34. Chuck, S., Grant, R. M., Katongole-Mbidde, E., Conant, M., and Ganem, D., 1996, Frequent presence of a novel herpesvirus genome in lesions of human immunodeficiency virus-negative Kaposi’s sarcoma, ℑ Infect. Dis. 173:248–251.

    CAS  Google Scholar 

  35. Peterman, T. A., Jaffe, H. W., Friedman-Kien, A. E., and Weiss, R. A., 1991, The aetiology of Kaposi’s sarcoma, in: The Aetiology of Kaposi’s Sarcoma, Vol. 10, Imperial Cancer Research Fund, London pp. 23–37.

    Google Scholar 

  36. Schalling, M., Ekman, M., Kaaya, E. E., Linde, A., and Biberfeld, P., 1995, A role for a new herpesvirus (KSHV) in different forms of Kaposi’s sarcoma, Nature Med. 1:707–708.

    PubMed  CAS  Google Scholar 

  37. Chang, Y., Ziegler, J. L., Wabinga, H. et al., 1996, Kaposi’s sarcoma-associated herpesvirus and Kaposi’s sarcoma in Africa, Arch. Int. Med. 156:202–204.

    Article  CAS  Google Scholar 

  38. Corbellino, M., Poirel, L., Bestetti, G. et al., 1996, Restricted tissue distribution of extralesional Kaposi’s sarcoma-associated herpesvirus-like DNA sequences in AIDS patients with Kaposi’s sarcoma, AIDS Res. Hum. Retrovirus 12:651–657.

    Article  CAS  Google Scholar 

  39. Corbellino, M., Parravincini, C., Aubin, J. T., and Berti, E., 1996, Kaposi’s sarcoma and herpesvirus-like DNA sequences in sensory ganglia, N Engl. J Med. 334:1341–1342.

    Article  PubMed  CAS  Google Scholar 

  40. Safai, B., Mikℑ, V., Giraldo, G., Beth, E., and Good, R. A., 1980, Association of Kaposi’s sarcoma with second primary malignancies, Cancer 45:1472–1479.

    PubMed  CAS  Google Scholar 

  41. Biggar, R. J., Curtis, R. E., Cote, T. R., Rabkin, C. S., and Melbye, M., 1994, Risk of other cancers following Kaposi’s sarcoma: Relation to acquired immunodeficiency syndrome. Am. J. Epidermiol. 139:362–368.

    CAS  Google Scholar 

  42. Frizzera, G., Banks, P. M., Massarelli, G., and Rosai, J., 1983, A systemic lymphoproliferative disorder with morphologic features of Castleman’s disease. Pathological findings in 15 patients. Am. ℑ Surg. Pathol. 7:211–231.

    CAS  Google Scholar 

  43. Varsano, S., Manor, Y., Steiner, Z., Griffel, B., and Klajman, A,, 1984, Kaposi’s sarcoma and angioimmunoblastic lymphadenopathy, Cancer 54(8):1582–1585.

    PubMed  CAS  Google Scholar 

  44. Karcher, D. S., and Alkan S., 1995, Herpes-like DNA sequences, AIDS-related tumors, and Castleman’s disease, New Eng. ℑ Med. 333(12):797–798.

    CAS  Google Scholar 

  45. Cesarman, E., Chang, Y., Moore, P. S., Said, J. W., and Knowles, D. M., 1995, Kaposi’s sarcoma-associated herpesvirus-like DNA sequences are present in AIDS-related body cavity based lymphomas, N. Engl. ℑ Med. 332:1186–1191.

    CAS  Google Scholar 

  46. Nador, R. G., Cesarman, E., Chadburn, A. et al., 1996, Primary effusion lymphoma: A distinct clinicopathologic entity associated with the Kaposi’s sarcoma-associated herpes virus, Blood 88(2):645–656.

    PubMed  CAS  Google Scholar 

  47. Knowles, D. M., Inghirami, G., Ubriaco, A., and Dalla-Favera, R., 1989, Molecular genetic analysis of three AIDS-associated neoplasms of uncertain lineage demonstrates their B-cell derivation and the possible pathogenetic role of Esptein-Barr virus, Blood 73:792–799.

    PubMed  CAS  Google Scholar 

  48. Cesarman, E., Nador, R. G., Aozasa, K., Delsol, G., Said, J. W., and Knowles, D. M., 1996, Kaposi’s sarcoma-associated herpesvirus in non-AIDS-related lymphomas occurring in body cavities, Am. ℑ Pathol. 149(1):53–57.

    CAS  Google Scholar 

  49. Strauchen, J. A., Hauser, A. D., Burstein, D. A., Jiminez, R., Moore, P. S., and Chang, Y., 1996, Body cavity-based malignant lymphoma containing Kaposi sarcoma-associated herpesvirus in an HIV-negative man with previous Kaposi sarcoma, Ann. Intern. Med. 125:822–825.

    PubMed  CAS  Google Scholar 

  50. Nador, R. G., Cesarman, E., Knowles, D. M., and Said, J. W., 1995, Herpes-like DNA sequences in a body cavity-based lymphoma in an HIV-negative patient, N. Engl. J Med. 333:943.

    Article  PubMed  CAS  Google Scholar 

  51. Renne, R., Zhong, W., Herndier, B., McGrath, M., Abbey, N., and Ganem, D., 1996, Lytic growth of Kaposi’s sarcoma-associated herpesvirus (human herpesvirus 8) in culture, Nature Med. 2:342–346.

    PubMed  CAS  Google Scholar 

  52. Kedes, D. H., Operskalski, E., Busche, M., Flood, J., Kohn, R., and Ganem, D., 1996, The seroepidemiology of human herpesvirus 8 (Kaposi’s sarcoma-associated herpesvirus): Distribution of infection in KS risk groups for sexual transmission, Nature Med. 2:918–924.

    PubMed  CAS  Google Scholar 

  53. Gao, S.-J., Kingsley, L., Li, M. et al., 1996, KSHV antibodies among Americans, Italians and Ugandans with and without Kaposi’s sarcoma, Nature Med. 2:925–928.

    PubMed  CAS  Google Scholar 

  54. Lennette, E. T., Blackbourne, D. J., and Levy, J. A., 1996, Antibodies to human herpesvirus type 8 in the general population and in Kaposi’s sarcoma patients, Lancet 348:858–861.

    Article  PubMed  CAS  Google Scholar 

  55. Corbellino, M., Poirel, L., Aubin, J. T. et al., 1996, The role of human herpesvirus 8 and Epstein-Barrvirus in the pathogenesis of giant lymph node hyperplasia (Castleman’s disease), Clin. Infect. Dis. 22:1120–1121.

    PubMed  CAS  Google Scholar 

  56. Soulier, J., Grollet, L., Oskenhendler, E. et al., 1995, Kaposi’s sarcoma-associated herpesvirus-like DNA sequences in multicentric Castleman’s disease, Blood 86:1276–1280.

    PubMed  CAS  Google Scholar 

  57. Dupin, N., Gorin, I., Deleuze, J., Agut, H., Huraux, J.-M., and Escande, J.-P., 1995, Herpes-like DNA sequences, AIDS-related tumors, and Castleman’s disease, N. Engl. ℑ Med. 333:797–798.

    Google Scholar 

  58. Gessain, A., Sudaka, A,, Briére, J. et al., 1996, Kaposi’s sarcoma-associated herpes-like virus (human herpesvirus type 8) DNA sequences in multicentric Castleman’s disease: Is there any relevant association in non-human immunodeficiency virus-infected patients?, Blood 87(1):414–416.

    PubMed  CAS  Google Scholar 

  59. Rady, P. L., Yen, A., Rollefson, J. L. et al., 1995, Herpesvirus-like DNA sequences in non-Kaposi’s sarcoma skin lesions of transplant patients, Lancet 345:1339–1340.

    PubMed  CAS  Google Scholar 

  60. Boshoff, C., Talbot, S., Kennedy, M. et al., 1996, New herpesvirus and immunosuppressed skin cancers, Lancet 347:338–339.

    Article  PubMed  CAS  Google Scholar 

  61. Adams, V., Kempf, W., Schmid, M., Müller, B., Briner, J., and Burg, G., 1995. Absence of herpesvirus-like DNA sequences in skin cancers of non-immunosuppressed patients, Lancet 346: 1715–1716.

    Article  PubMed  CAS  Google Scholar 

  62. Dictor, M., Rambech, E., Way, D., Witte, M., and Bendsöe, N., 1996, Human herpesvirus 8 (Kaposi’s sarcoma-associated herpesvirus) DNA in Kaposi’s sarcoma lesions, AIDS Kaposi’s sarcoma cell lines, endothelial Kaposi’s sarcoma stimulators, and the skin of immunosuppressed patients, Am. ℑ Pathol. 148:2009–2016.

    CAS  Google Scholar 

  63. Gyulai, R., Kemeny, L., Kiss, M., Adam, E., Nagy, F., and Dobozy, A., 1996, Herpesvirus-like DNA sequence in angiosarcoma in a patient without HIV infection. N Engl. ℑ Med. 334:540–541.

    CAS  Google Scholar 

  64. Gyulai, R., Kemeny, L., Adam, E., Nagy, F. and Dobozy, A., 1996, HHV8 DNA in angiolymphoid hyperplasia of the skin, Lancet 347:1837.

    Article  PubMed  CAS  Google Scholar 

  65. McDonagh, D. P., Liu, J., Gaffey, M. J., Layfield, L. J., Azumi, N., and Traweek, S. T., 1996, Detection of Kaposi’s sarcoma-associated herpesvirus-like DNA sequences in angiosarcoma, Am. ℑ Pathol. 149:1363–1368.

    CAS  Google Scholar 

  66. Boshoff, C., Whitby, D., Hatziionnou, T. et al., 1995, Kaposi’s sarcoma-associated herpesvirus in HIV-negative Kaposi’s sarcoma, Lancet 345:1043–1044.

    PubMed  CAS  Google Scholar 

  67. Tomita, Y., Kaka, N., Aozasa, K., Cesarman, E., and Knowles, D. M., 1996, Absence of Kaposi’s sarcoma-associated herpesvirus-like DNA sequences (KSHV in angiosarcomas developing in body-cavity and other sites, Int. ℑ Cancer 66:141–142.

    CAS  Google Scholar 

  68. Jin, Y.-T., Tsai, S.-T., Yan, J.-J., Hsiao, J.-H., Lee, Y.-Y., and Su, I.-J., 1996, Detection of Kaposi’s sarcoma-associated herpesvirus-like DNA sequence in vascular lesions: A reliable diagnostic marker for Kaposi’s sarcoma, Am. ℑ Clin. Pathol. 105:360–363.

    CAS  Google Scholar 

  69. Lin, J.-C., Lin, S.-C., Mar, E.-C. et al., 1995, Is Kaposi’s sarcoma-associated herpesvirus detectable in semen of HIV-infected homosexual men?, Lancet 346:1601–1602.

    Article  PubMed  CAS  Google Scholar 

  70. Monini, P., de Lellis, L., Fabris, M., Rigolin, F., and Cassai, E., 1996, Kaposi’s sarcoma-associated herpesvirus DNA sequences in prostate tissue and human semen, N Engl. J. Med. 334:1168–1172.

    Article  PubMed  CAS  Google Scholar 

  71. Corbellino, M., Bestetti, G., Galli, M., and Parravincini, C., 1996, Absence of HHV-8 in prostate and semen, N. Engl. J. Med. 335:1237.

    Article  PubMed  CAS  Google Scholar 

  72. Tasaka, T., Said, J. W., Koeffler, H. P., 1996, Absence of HHV-8 in prostate and semen, N. Engl. J Med. 335:1237–1238.

    PubMed  CAS  Google Scholar 

  73. Gupta, P., Mandaleshwar, D. S., Rinaldo, C. et al., 1996, Detection of Kaposi’s sarcoma herpesvirus DNA in semen of homosexual men with Kaposi’s sarcoma, AIDS 10: 1596–1598.

    Article  PubMed  CAS  Google Scholar 

  74. Howard, M. R., Whitby, D., Bahadur, G. et al., 1997, Detection of human herpesvirus 8 DNA in semen from HIV-infected individuals but not healthy semen donors, AIDS 11:F15–F19.

    Article  PubMed  CAS  Google Scholar 

  75. Monini, P., de Lellis, L., and Cassai, E., 1996, Absence of HHV-8 in prostate and semen, N. Engl. J Med. 335:1238–1239.

    Google Scholar 

  76. Miller, G., Rigsby, M., Heston, L. et al., 1996, Antibodies to butyrate inducible antigens of Kaposi’s sarcoma-associated herpesvirus in HIV-1 infected patients, N. Engl. ℑ. Med. 334: 1292–1297.

    CAS  Google Scholar 

  77. Gao, S.-J., Kingsley, L., Hoover, D. R. et al., 1996, Seroconversion of antibodies to Kaposi’s sarcoma-associated herpesvirus-related latent nuclear antigens prior to onset of Kaposi’s sarcoma, N. Engl.J Med. 335:233–241.

    Article  PubMed  CAS  Google Scholar 

  78. Rainbow, L., Platt, G. M., Simpson, G. R. et al., 1997, The 226-to 234-kilodalton latent nuclear protein (LNA) of Kaposi’s sarcoma-associated herpesvirus (KSHV/ HHV8) is encoded by ORF73 and is a component of the latency-associated nuclear antigen, ℑ Virol. 71: 5919–5921.

    Google Scholar 

  79. Simpson, G. R., Schulz, T. F., Whitby, D. et al., 1996, Prevalence of Kaposi’s sarcoma-associated herpesvirus infection measured by antibodies to recombinant capsid protein and latent immunofluorescence antigen, Lancet 348: 1133–1138.

    Article  PubMed  CAS  Google Scholar 

  80. Klein, G., 1994, Epstein-Barr Virus strategy in normal and neoplastic B cells, Cell 77:791–793.

    Article  PubMed  CAS  Google Scholar 

  81. Moore, P. S., Kingsley, L., Holmberg, S. D. et al., 1996, Kaposi’s sarcoma-associated herpesvirus infection prior to onset of Kaposi’s sarcoma, AIDS 10: 175–180.

    PubMed  CAS  Google Scholar 

  82. Whitby, D., Howard, M.R., Tenant-Flowers, M. et al., 1995, Detection of Kaposi’s sarcoma-associated herpesvirus (KSHV) in peripheral blood of HIV-infected individuals predicts progression to Kaposi’s sarcoma, Lancet 364:799–802.

    Google Scholar 

  83. Decker, L. L., Shankar, P., Khan, G. et al., 1996, The Kaposi’s sarcoma-associated herpesvirus (KSHV) is present as an intact latent genome in KS tissue but replicates in the peripheral blood mononuclear cells of KS patients, ℑ Exp. Med. 184:283–288.

    CAS  Google Scholar 

  84. Gaidano, G., Pastore, C., Gloghini, A. et al., 1996, Distribution of human herpesvirus-8 sequences throughout the spectrum of AIDS-related neoplasia, AIDS 10:941–949.

    Article  PubMed  CAS  Google Scholar 

  85. Boshoff, C., Schulz, T. F., Kennedy, M. M. et al., 1995, Kaposi’s sarcoma-associated herpes virus (KSHV) infects endothelial and spindle cells, Nature Med. 1:1274–1278.

    PubMed  CAS  Google Scholar 

  86. Li, J. J., Huang, Y. Q., Cockerell, C. J., and Fliedman-Kien, A. E., 1996, Localization of human herpes-like virus type 8 in vascular endothelial cells and perivascular spindle-shaped cells of Kaposi’s sarcoma lesions by in situ hybridization, Am. J. Pathol. 148:1741–1748.

    PubMed  CAS  Google Scholar 

  87. Staskus, K. A., Zhong, W., Gebhard, K. et al., 1997, Kaposi’s sarcoma-associated herpesvirus gene expression in endothelial (spindle) tumor cells, ℑ Virol 71:715–719.

    CAS  Google Scholar 

  88. Lebbé, C., Pellet, C., Tatoud, R. et al., 1997, Absence of human herpesvirus 8 sequences in prostate specimens, AIDS 11:270.

    PubMed  Google Scholar 

  89. Rubin, M. A., Parry, J. P., and Singh, B., 1997, Kaposi’s sarcoma-associated herpesvirus deoxyribonucleic acid sequences: Lack of expression in prostatic tissue of human immunodeficiency virus-negative immunocompetent adults, ℑ Urol. 159:146–148.

    Google Scholar 

  90. Fleckenstein, B., and Desrosiers, R. C., 1982, Herpesvirus saimiri and herpesvirus ateles, in: Herpesvirus saimiri and Herpesvirus ateles, (B. Roizman, ed.), Raven Press, New York.

    Google Scholar 

  91. Russo, J. J,, Bohenzky, R. A., Chien, M. et al., 1996, Nucleotide sequence of Kaposi’s sarcoma-associated herpesvirus (HHV8), Proc. Natl. Acad. Sci. USA 93:14862–14867.

    PubMed  CAS  Google Scholar 

  92. Cesarman, E., Nador, R. G., Bai, F. et al., 1996, Kaposi’s sarcoma-associated herpesvirus contains G protein-coupled receptor and cyclin D homologs which are expressed in Kaposi’s sarcoma and malignant lymphoma, J Virol. 70:8218–8223.

    PubMed  CAS  Google Scholar 

  93. Peters, G., 1994, The D-type cyclins and their role in tumorigenesis, ℑ CellSci. Suppl.18: 89–96.

    Google Scholar 

  94. Yatabe, Y., Nakamura, S., Seto, M. et al., 1996, Clinicopathologic study of PRAD1 /cyclin D1 overexpressing lymphoma with special reference to mantle cell lymphoma. A distinct pathologic entity, Am.J. Surg. Pathol. 20:1110–1122.

    Article  PubMed  CAS  Google Scholar 

  95. Chang, Y., Moore, P. S., Talbot, S. J. et al., 1996, Cyclin encoded by KS herpesvirus, Nature 382:410.

    Article  PubMed  CAS  Google Scholar 

  96. Li, M., Lee, H., Yoon, D.-W., et al., 1997, Kaposi’s sarcoma-associated herpesvirus encodes a functional cyclin, J Virol. 71:1984–1991.

    PubMed  CAS  Google Scholar 

  97. Godden-Kent, D., Talbot, S. J., Boshoff, C. et al., 1997, The cyclin encoded by Kaposi’s sarcoma associated herpesvirus (KSHV) stimulates cdk6 to phosphorylate the retinoblastoma protein and Histone H1, ℑ Virol. 71:4193–4198.

    CAS  Google Scholar 

  98. White, E., 1994, Tumour biology. p53, guardian of Rb, Nature 371(6492):21–22.

    Article  PubMed  CAS  Google Scholar 

  99. Sarid, R., Sato, T., Bohenzky, R. A., Russo, J. J., and Chang, Y., 1997, Kaposi’s sarcoma-associated herpesvirus encodes a functional Bcl-2 homolog, Nature Med. 3:1–6.

    Google Scholar 

  100. Cheng, E.H.-Y., Nicholas, J., Bellows, D. S. et al., 1997, A Bcl-2 homolog encoded by Kaposi sarcoma-associated virus, human herpesvirus 8, inhibits apoptosis but does not heterodimerize with Bax or Bak, Proc. Natl. Acad. Sci. USA 94:690–694.

    PubMed  CAS  Google Scholar 

  101. Reed, J. C., Miyashita, T., Krajewski, S. et al., 1996, Bcl-2 family proteins and the regulation of programmed cell death in leukemia and lymphoma, Cancer Treatment Res. 84:31–72.

    CAS  Google Scholar 

  102. Moore, P. S., Boshoff, C., Weiss, R. A., and Chang, Y., 1996, Molecular mimicry of human cytokine and cytokine-response pathway genes by KSHV, Science 274:1739–1744.

    PubMed  CAS  Google Scholar 

  103. Nicholas, J., Ruvolo, V. R., Burns, W. H. et al., 1997, Kaposi’s sarcoma-associated human herpesvirus-8 encodes homologues of macrophage inflammatory protein-1 and interleukin-6, Nature Med. 3: 287–292.

    PubMed  CAS  Google Scholar 

  104. Molden, J., Chang, Y., Yun, Y., Moore, P. S., and Goldsmith, M. A., 1997, A KSHV-encoded cytokine homologue (vII-6) activates signaling through the shared gp130 receptor subunit, J Biol. Chem. 272:19625–19631.

    Article  PubMed  CAS  Google Scholar 

  105. Gao, S.-J., Boshoff, C., Jayachandra, S., Weiss, R. A., Chang, Y., and Moore, P. S., 1997, KSHV ORF K9 (vIRE) is an oncogene which inhibits the interferon signaling pathway, Oncogene 15:1979–1985.

    Article  PubMed  CAS  Google Scholar 

  106. Arvanitakis, L., Geras-Raaka, E., Varma, A., Gershengorn, M. C., and Cesarman, E., 1997, Human herpesvirus KSHV encodes a constitutively active G-protein-coupled receptor linked to cell proliferation, Nature 385:347–349.

    Article  PubMed  CAS  Google Scholar 

  107. Jones, J., Peterman, T., Chu, S., and Jaffe, H., 1995, AIDS-associated Kaposi’s sarcoma, Science 267:1078–1079.

    PubMed  CAS  Google Scholar 

  108. Glesby, M. J., Hoover, D. R., Weng, S. et al., 1996, Use of antiherpes drugs and the risk of Kaposi’s sarcoma: Data from the Multicenter AIDS Cohort Study, ℑID 173: 1477–1480.

    CAS  Google Scholar 

  109. Mocroft, A., Youle, M., Gazzard, B., Morcinek, J., Halai, R., and Phillips, A. N., 1996, Anti herpesvirus treatment and risk of Kaposi’s sarcoma in HIV infection, AIDS 10:1101–1105.

    Article  PubMed  CAS  Google Scholar 

  110. Morfeldt, L., and Torsander, J., 1994, Long-term remission of Kaposi’s sarcoma following foscarnet treatment in HIV-infected patients, Scand. J. Infect. Dis. 26:749.

    Article  PubMed  CAS  Google Scholar 

  111. Kedes, D. H., and Ganem, D., 1997, Susceptibility of KSHV (HHV8) to antiviral drugs in culture. ℑ Clin. Invest. 99:2082–2086.

    CAS  Google Scholar 

  112. Boshoff, C., Gao, S.-J., Healy, L. et al., 1997, In vivo characterization of KSHV positive primary effusion lymphoma (PEL) cells, Blood, in press.

    Google Scholar 

  113. Huang, Y.-Q, Li, J. J., Poiesz, B. J., Kaplan, M. H., and Friedman-Kien, A. E., 1997, Detection of the herpesvirus-like DNA sequences in matched specimens of semen and blood from patients with AIDS-related Kaposi’s sarcoma by polymerase chain reaction in situ hybridization, Amer. ℑ Pathol. 150: 147–153.

    CAS  Google Scholar 

  114. Thomas, J. A., Brookes, L. A., McGowan, I., Weller, I., and Crawford, D. H., 1996, HHV8 DNA in normal gastrointestinal mucosa from HIV seropositive people, Lancet 347:1337–1338.

    PubMed  CAS  Google Scholar 

  115. Tirelli, U., Gaidano, G., Errante, D., and Carbone, A., 1996, Potential heterosexual Kaposi’s sarcoma-associated herpesvirus transmission in a couple with HIV-induced immunodepression and with Kaposi’s sarcoma and multicentric Castleman’s disease, AIDS 10(1 1) 1291–1292.

    PubMed  CAS  Google Scholar 

  116. Olsen, S. J., Chang, Y., Moore, P. S., Biggar, R. J., and Melbye, M., 1998, Increasing Kaposi’s sarcoma-associated herpesvirus seroprevalence with age in a highly Kaposi’s sarcoma endemic region, Zambia in 1985, AIDS 12 (in press).

    Google Scholar 

  117. Melbye, M., Bayley, A., Manuwele, J., et al., 1986, Evidence for heterosexual transmission and clinical manifestations of human immunodeficiency virus infection and related conditions in Lusaka, Zambia, Lancet 15 Nov.: 109–111.

    Google Scholar 

  118. Boldough, I., Szaniszlo, P., Bresnahan, W. A., Flaitz, C. M., Nichols M. C., and Albrecht, T., 1996, Kaposi’s sarcoma herpesvirus-lie DNA sequences in the saliva of individuals infected with human immunodeficiency virus, Clin. Infect. Dis. 23:406–407.

    Google Scholar 

  119. Koelle, D. M., Huang, M.-L., Vieira, J., Berger, D., Piepkorn, M., and Corey L. Detection of Kaposi’s sarcoma-associated herpesvirus in saliva of human immunodeficiency virus infected individuals with and without Kaposi’s sarcoma. ICAAC, New Orleans, ASM, 1996.

    Google Scholar 

  120. Vieira, J., Koelle, D., Huang, M.-L., and Corey, L., Transmissible Kaposi’s associated herpesvirus(KSHV) in saliva, Fourth Conference on Retroviruses and Opportunistic Infections, Washington, D. C., 1997.

    Google Scholar 

  121. Ziegler, J. L., and Katongole-Mbidde, E., 1996, Kaposi’s sarcoma in childhood: An analysis of 100 cases from Uganda and relationship to HIV infection, Int. ℑ Cancer 65:200–203.

    Google Scholar 

  122. Parravicini, C., Olsen, S. J., Capra, M. et al., 1997, Risk of Kaposi’s sarcoma-associated herpes virus transmission from donor allografts among Italian posttransplant Kaposi’s sarcoma patients, Blood 90:2826–2829.

    PubMed  CAS  Google Scholar 

  123. Su, I.-J., Hsu, Y.-S., Chang, Y.-C., and Wang, I.-W., 1995, Herpesvirus-like DNA sequence in Kaposi’s sarcoma from AIDS and non-AIDS patients in Taiwan, Lancet 345:722–723.

    Article  PubMed  CAS  Google Scholar 

  124. Moore, P. S., and Change, Y., 1995, Detection of herpesvirus-like DNA sequences in Kaposi’s sarcoma lesions from persons with and without HIV infection, New Eng. ℑ Med. 332:1181–1185.

    CAS  Google Scholar 

  125. O’Neill, E., Henson, T. H., Ghorbani, A. J., Land, M. A., Webber, B. L., and Garcia, J. V., 1996, Herpes virus-like sequences are specifically found in Kaposi sarcoma lesions, ℑ Clin. Pathol. 49:306–308.

    Google Scholar 

  126. Buonaguro, F. M., Tornesello, M. L. Beth-Giraldo, E., et al., 1996, Herpesvirus-like DNA sequences detected in endemic, classic, iatrogenic and epidemic Kaposi’s sarcoma (KS) biopsies, Int. ℑ Cancer 65:25–28.

    CAS  Google Scholar 

  127. Cathomas, G., McGandy, C. E., Terracciano, L. M., Itin, P. H., de, R. G., and Gudat, F., 1996, Detection of herpesvirus-like DNA by nested PCR on archival skin biopsy specimens of various forms of Kaposi sarcoma, ℑ Clin. Pafhol. 49(8):631–633.

    CAS  Google Scholar 

  128. Marchioli, C. C., Love, J. L., Abbott, L. Z., et al., 1996, Prevalence of human herpesvirus 8 DNA sequences in several patient populations, ℑ Clin. Microbiol. 34(10):2635–2638.

    CAS  Google Scholar 

  129. Luppi, M., Barozzi, P., Maiorana, A., et al., Frequency and distribution ofherpesvirus-like DNA sequences (KSHV) in different stages of classic Kaposi’s sarcoma and in normal tissues from an Italian population, Int. ℑ Cancer 66:427–431.

    Google Scholar 

  130. Lebbé, C., Agbalika, F., de Cremaux, P., et al., 1997, Detection of human herpesvirus 8 and human T-cell lymphotropic virus type 1 sequences in Kaposi sarcoma, Arch. Dermatol. 133(1):25–30.

    PubMed  Google Scholar 

  131. Collandre, H., Ferris, S., Grau, O., Montagnier, L., and Blanchard, A., 1995, Kaposi’s sarcoma and new herpesvirus, Lancet 345:1043.

    Article  PubMed  CAS  Google Scholar 

  132. Humphrey, R. W., O’Brien, T. R., Newcomb, F. M., et al., 1996, Kaposi’s sarcoma (KS)-associated herpesvirus-like DNA sequences in peripheral blood mononuclear cells: Association with KS and persistence in patients receiving anti-herpesvirus drugs, Blood 88(1):297–301.

    PubMed  CAS  Google Scholar 

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  1. Division of Epidemiology, Columbia University School of Public Health, New York, New York, 10032

    Sonja J. Olsen & Patrick S. Moore

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  1. University of South Florida College of Medicine, Tampa, Florida

    Peter G. Medveczky  & Herman Friedman  & 

  2. University of Pisa, Pisa, Italy

    Mauro Bendinelli

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Olsen, S.J., Moore, P.S. (2002). Kaposi’s Sarcoma-Associated Herpesvirus (KSHV/HHV8) and the Etiology of KS. In: Medveczky, P.G., Friedman, H., Bendinelli, M. (eds) Herpesviruses and Immunity. Infectious Agents and Pathogenesis. Springer, Boston, MA. https://doi.org/10.1007/0-306-46808-5_5

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  • DOI: https://doi.org/10.1007/0-306-46808-5_5

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