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Nitroxides as Protectors Against Oxidative Stress

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Reactive Oxygen Species in Biological Systems

Summary

The use of nitroxides has been greatly expanded over the past few years with the discovery of their antioxidant activity. The ability of nitroxides to function as mimics of antioxidant enzymes such as SOD and catalase and their ability to act as efficient radical scavengers are unique protective capabilities. The observed protective effects of nitroxides at the cellular and animal level against diverse oxidative insults have made them potentially useful as agents to assess free radical modes of cytotoxicity and as anew class of antioxidants that may have utility in clinical biomedical research.

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Authors and Affiliations

  1. Radiation Biology Branch, National Cancer Instilute, National Institutes of Health, Bethesda, Maryland, 20892

    James B. Mitchell, Murali C. Krishna & Angelo Russo

  2. Molecular Biology, School of Medicine, Hebrew University, Jerusalem, 91010, Israel

    Amram Samuni

  3. Department of Radiation Oncology, University of Pennsylvania, Philadelphia, Pennsylvania, 19104

    Stephen M. Hahn

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  1. James B. Mitchell
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  2. Murali C. Krishna
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  3. Amram Samuni
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  4. Angelo Russo
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  5. Stephen M. Hahn
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© 2002 Kluwer Academic Publishers

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Mitchell, J.B., Krishna, M.C., Samuni, A., Russo, A., Hahn, S.M. (2002). Nitroxides as Protectors Against Oxidative Stress. In: Reactive Oxygen Species in Biological Systems. Springer, Boston, MA. https://doi.org/10.1007/0-306-46806-9_11

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  • DOI: https://doi.org/10.1007/0-306-46806-9_11

  • Publisher Name: Springer, Boston, MA

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