Chapter

Ras Superfamily Small G Proteins: Biology and Mechanisms 1

pp 395-419

Date:

Principles Driving the Spatial Organization of Rho GTPase Signaling at Synapses

  • Scott H. SoderlingAffiliated withDepartments of Cell Biology and Neurobiology, Duke University Medical School Email author 
  • , Linda Van AelstAffiliated withCold Spring Harbor Laboratory Email author 

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Abstract

The Rho proteins play critical roles in numerous aspects of neuronal development, and mutations in their regulators (GEFs and GAPs) and effectors underlie multiple neurodevelopmental and neurological disorders. How Rho GTPase-mediated signaling can have a hand in regulating so many different neurobiological processes remains a challenging question. An emerging theme is that GAPs and GEFs, through their spatial/temporal regulation and/or through additional protein–protein interactions, cooperate in making connections between upstream signals and the downstream signaling output, engaging distinct effector proteins. This chapter focuses on recent evidence illustrating distinct modes of regulation and specialized roles of Rho regulators particularly in the context of synaptic structure, function, and plasticity, and how their dysregulation affects behavioral processes and contributes to disease.

Keywords

Rho regulators Rho effectors Neuronal development Synaptic structure and function Brain disorders