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Transgenic Animals as Bioreactors for Therapeutic and Nutritional Proteins

  • Conference paper
Transgenic Animals as Model Systems for Human Diseases

Part of the book series: Schering Foundation Workshop ((SCHERING FOUND,volume 6))

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Abstract

The development of molecular “pharming” technology culminated in transgenic animals whose mammary glands were converted into bioreactors producing human proteins. This was achieved with interdigitative efforts by several branches of science — molecular biology, embryology, and protein chemistry. Protein chemistry helps to identify sequences of milk proteins, molecular biology provides the tools for the isolation of genetic regulatory elements that target gene expression to mammary tissue, and embryology is critical for the introduction of novel genes into embryos from which transgenic animals are derived. An important focus of current investigation in the field of mammary biotechnology comes from our accumulating understanding of molecular gene switches in the context of complex chromatin.

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Authors
  1. Lothar Hennighausen
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  2. Avi Shamay
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  3. Priscilla A. Furth
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  4. Robert A. McKnight
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  5. Caird Rexroad Jr.
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  6. Vern G. Pursel
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  7. Robert J. Wall
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Editor information

Editors and Affiliations

  1. Research Institute of Molecular Pathology (IMP), Dr. Bohr-Gasse 7, A-1030, Vienna, Austria

    Erwin F. Wagner

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© 1993 Springer-Verlag Berlin Heidelberg

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Hennighausen, L. et al. (1993). Transgenic Animals as Bioreactors for Therapeutic and Nutritional Proteins. In: Wagner, E.F., Theuring, F. (eds) Transgenic Animals as Model Systems for Human Diseases. Schering Foundation Workshop, vol 6. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-02925-1_8

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  • DOI: https://doi.org/10.1007/978-3-662-02925-1_8

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-02927-5

  • Online ISBN: 978-3-662-02925-1

  • eBook Packages: Springer Book Archive

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