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Patterns of Growth Hormone Release During Childhood and Adolescent Development in the Human

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Biologic Rhythms in Clinical and Laboratory Medicine

Abstract

Growth hormone (GH) is released in an episodic, burst-like (pulsatile) manner throughout the day, but especially following the onset of slow-wave sleep (stages 3 and 4). Its secretion is controlled by two hypothalamic peptide hormones — growth hormone-releasing hormone (GHRH) and growth hormone release inhibiting hormone (somatostatin). Additional loci of control include brain neurotransmitters and neuropeptides, insulin-like growth factor-I [IGF-I (long-loop feedback)], GH itself (short-loop feedback) and GH-RH and somatostatin (ultrashort-loop feedback). In addition, metabolic substrates, e.g., glucose and fatty acids, take part in the regulation of growth hormone secretion. It is the quantity and pattern of circulating GH that ultimately permits the animal to grow, although genetic, disease and especially nutritional factors may override any straightforward relationship between GH secretion and linear growth.

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References

  • Albertsson-Wikland K, Rosberg S (1988) Analyses of 24-hour growth hormone profiles in children; relation to growth. J Clin Endocrinol Metab 67: 493–500

    Article  PubMed  CAS  Google Scholar 

  • Benedict PH (1962) Endocrine features in Albright’s syndrome (fibrous dysplasia of bone). Metabolism 11: 30–45

    PubMed  CAS  Google Scholar 

  • Berelowitz M, Szabo M, Frohman LA (1981) Somatomedin-C mediates GH negative feedback by effects on both the hypothalamus and the pituitary. Science 212:1279–1281

    Article  PubMed  CAS  Google Scholar 

  • Bierich JR (1983) Treatment of constitutional delay of growth and adolescence with human growth hormone. Klin Pedi-atr 195: 309–316

    Article  CAS  Google Scholar 

  • Evans WS, Faria ACS, Christiansen E, Ho KY, Weiss J, Rogol AD, Johnson ML, Blizzard RM, Veldhuis JD, Thorner MO (1987) Impact of intensive venous sampling on characterization of pulsatile GH release. Am J Physiol 252: E549-E556

    PubMed  CAS  Google Scholar 

  • Hartman ML, Veldhuis JD, Vance ML, Faria ACS, Furlanetto RW, Thorner MO (1990) Somatotropin pulse frequency and basal concentrations are increased in acromegaly and are reduced by successful therapy. J Clin Endocrinol Metab 70: 1375–1384

    Article  PubMed  CAS  Google Scholar 

  • Hindmarsh P, Smith PJ, Brook CGD, Matthews DR (1987) The relationship between height velocity and growth hormone secretion in short prepubertal children. Clin Endocrinol (Oxf) 27: 581–591

    Article  CAS  Google Scholar 

  • Ho KY, Evans WS, Blizzard RM, Veldhuis JD, Merriam GR, Samojlik E, Furlanetto RW, Rogol AD, Kaiser DL, Thorner MO (1987) Effects of sex and age on the 24-hr secretory profile of GH secretion in man: importance of endogenous estradiol concentrations. J Clin Endocrinol Metab 64: 51–58

    Article  PubMed  CAS  Google Scholar 

  • Isgaard J, Møller C, Isaksson OG, Nilsson A, Mathews LS, Nor-stedt G (1988) Regulation of insulin-like growth factor messenger ribonucleic acid in rat growth plate by growth hormone. Endocrinology 122:1515–1520

    Article  PubMed  CAS  Google Scholar 

  • Isley WL, Underwood LE, Clemmons DR (1983) Dietary components that regulate serum somatomedin C concentrations in humans. J Clin Invest 71:175–182

    Article  PubMed  CAS  Google Scholar 

  • Kerrigan JR, Martha PM Jr, Blizzard RM, Christie CM, Rogol AD (1990) Variations of pulsatile growth hormone release in healthy short prepubertal boys. Pediatr Res 28:11–14

    Article  PubMed  CAS  Google Scholar 

  • Kovacs K, Horvath E, Thorner MO, Rogol AD (1984) Mam-mosomatotroph hyperplasia associated with acromegaly and hyperprolactinemia in a patient with the McCune-Albright syndrome. Virchows Arch A 403: 77–86

    Article  CAS  Google Scholar 

  • Link K, Blizzard RM, Evans WS, Kaiser DL, Parker MW, Rogol AD (1986) The effects of androgens on the pulsatile release and the twenty-four-hour mean concentration of growth hormone in peripubertal males. J Clin Endocrinol Metab 62:159–164

    Article  PubMed  CAS  Google Scholar 

  • Liu L, Merriam GR, Sherins RJ (1987) Chronic sex steroid exposure increases mean plasma growth hormone concentration and pulse amplitude in men with isolated hypogonada-tropic hypogonadism. J Clin Endocrinol Metab 64: 651–656

    Article  PubMed  CAS  Google Scholar 

  • Marshall WA, Tanner JM (1970) Variation in the pattern of pubertal changes in boys. Arch Dis Child 45:13–23

    Article  PubMed  CAS  Google Scholar 

  • Martha PM Jr, Blizzard RM, Rogol AD (1988) Atenolol enhances growth hormone release to exogenous growth hormone-releasing hormone but fails to alter spontaneous nocturnal growth hormone secretion in boys with constitutional delay of growth. Pediatr Res 23: 393–397

    Article  PubMed  Google Scholar 

  • Martha PM Jr, Rogol AD, Veldhuis JD, Kerrigan JR, Goodman DW, Blizzard RM (1989) Alterations in the pulsatile properties of circulating growth hormone concentrations during puberty in boys. J Clin Endocrinol Metab 69: 563–570

    Article  PubMed  CAS  Google Scholar 

  • Mauras N, Blizzard RM, Link K, Johnson ML, Rogol AD, Veldhuis JD (1987) Augmentation of growth hormone secretion during puberty: evidence for a pulse amplitude-modulated phenomenon. J Clin Endocrinol Metab 64: 596–601

    Article  PubMed  CAS  Google Scholar 

  • Mauras N, Blizzard RM, Rogol AD (1989) Androgen-depen-dent somatotroph function in a hypogonadal adolescent male: evidence for control of exogenous androgens on growth hormone release. Metabolism 38: 286–289

    Article  PubMed  CAS  Google Scholar 

  • Mauras N, Rogol AD, Veldhuis JD (1989) Specific, time-dependent actions of low-dose ethinylestradiol administration on the episodic release of growth hormone, follicle stimulating hormone and luteinizing hormone in prepubertal girls with Turner’s syndrome. J Clin Endocrinol Metab 69:1053–1058

    Article  PubMed  CAS  Google Scholar 

  • Mauras N, Rogol AD, Veldhuis JD (1990) Increased hGH production rate after low dose estrogen therapy in pre-pubertal girls with Turner’s syndrome. Pediatr Res 28: 626–630

    Article  PubMed  CAS  Google Scholar 

  • Müller EE, Nisticó G (1989) Brain messengers and the pituitary. Academic, New York

    Google Scholar 

  • Plotsky PM, Vale W (1985) Patterns of growth hormone-releasing factor and somatostatin secretion into the hypophysial-portal circulation of the rat. Science 230: 461–463

    Google Scholar 

  • Rivier J, Spiess J, Thorner M, Vale W (1982) Characterization of a growth hormone releasing factor from a human pancreatic islet tumour. Nature 300: 276–278

    Article  PubMed  CAS  Google Scholar 

  • Rosenthal SM, Hulse JA, Kaplan SL, Grumbach MM (1986) Exogenous growth hormone inhibits growth hormone-releasing factor-induced growth hormone secretion in normal men. J Clin Invest 77:176–180

    Article  PubMed  CAS  Google Scholar 

  • Sanayama K, Noda H, Konda S, Ikeda F, Murata A, Sasaki N, Niimi H, Nakajima H (1987) Spontaneous growth hormone secretion and plasma somatomedin-C in children of short stature. Endocrinol Jpn 34: 627–633

    Article  PubMed  CAS  Google Scholar 

  • Spiliotis BE, August GP, Hung W, Sonis W, Mendelson W, Bercu BB (1984) Growth hormone neurosecretory dysfunction; a treatable cause of short stature: JAMA 251: 2223–2230

    Google Scholar 

  • Tanner JM, Davies PW (1985) Clinical longitudinal standards for height and height velocity for Northern American children. J Pediatr 107: 317–329

    Article  PubMed  CAS  Google Scholar 

  • Tanner JM, Whitehouse RH, Takaishi M (1966) Standards from birth to maturity for height, weight, height velocity, and weight velocity: British children 1965. II. Arch Dis Child 41: 613–635

    Article  PubMed  CAS  Google Scholar 

  • Tanner JM, Whitehouse RH, Hughes PCR, Carter BS (1976) Relative importance of growth hormone and sex steroids for the growth at puberty of trunk length, limb length, and muscle width in growth hormone-deficient children. J Pediatr 89:1000–1008

    Article  PubMed  CAS  Google Scholar 

  • Ulloa-Aguirre A, Ghristie CM, Carcia-Rubi E, Rogol AD, Link K, Blizzard RM, Johnson ML, Veldhuis JD (1990) Testosterone and oxandrolone a non-aromatizable androgen specifically amplify the mass and rate of growth hormone (GH) release secreted per burst without altering GH secretory burst duration or frequency or the half-life. J Clin Endocrinol Metab 71: 846–854

    Article  PubMed  CAS  Google Scholar 

  • Urban RJ, Rogol AD, Evans JW, Johnson ML, Veldhuis JD (1988) Contemporary aspects of endocrine signal analysis. I. The paradigm of the luteinizing hormone pulse signal in men. Endocr Rev 9: 3–37

    Article  PubMed  CAS  Google Scholar 

  • Veldhuis JD, Johnson ML (1986) Cluster analysis: a simple, versatile and robust algorithm for endocrine pulse detection. Am J Physiol 250: E486-E493

    PubMed  CAS  Google Scholar 

  • Veldhuis JD, Carlson ML, Johnson ML (1987) The pituitary gland secretes in bursts: appraising the nature of glandular secretory impulses by simultaneous multiple-parameter decon-volution of plasma hormone concentrations. Proc Natl Acad Sci USA 84:7686–7690

    Article  PubMed  CAS  Google Scholar 

  • Zadik Z, Chalew SA, Raiti S, Kowarski AA (1985) Do short children secrete insufficient growth hormone? Pediatrics 76: 355–360

    PubMed  CAS  Google Scholar 

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Authors
  1. A. D. Rogol
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Editors and Affiliations

  1. Faculté de Médecine Pitié-Salpétrière, Laboratoire de Biochimie Médicale, 91, Boulevard de l’Hôpital, 75634, Paris Cedex 13, France

    Yvan Touitou (Professor of Biochemistry) (Professor of Biochemistry)

  2. Department of Laboratory Medicine and Pathology, University of Minnesota, 640 Jackson Street, 55101-259, St.Paul, MN, USA

    Erhard Haus (Professor, Chairman) (Professor, Chairman)

  3. Department of Anatomic and Clinical Pathology, St. Paul-Ramsey Medical Center, 640 Jackson Street, 55101-259, St.Paul, MN, USA

    Erhard Haus (Professor, Chairman) (Professor, Chairman)

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© 1992 Springer-Verlag Berlin Heidelberg

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Rogol, A.D. (1992). Patterns of Growth Hormone Release During Childhood and Adolescent Development in the Human. In: Touitou, Y., Haus, E. (eds) Biologic Rhythms in Clinical and Laboratory Medicine. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78734-8_12

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  • DOI: https://doi.org/10.1007/978-3-642-78734-8_12

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-78736-2

  • Online ISBN: 978-3-642-78734-8

  • eBook Packages: Springer Book Archive

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