Abstract
Sophora japonica L. (Fabaceae) is a well-known herbal medicine which has been used in traditional Chinese medicine for a long time. Three entries are listed in the Chinese Pharmacopoeia:
-
Huaimi, Flos Sophora immaturus, is the dry flower buds of S. japonica collected in summer. The rutin content in the flower buds should not be less than 20%. It is used mainly as a hemostatic agent for the treatment of different hemorrhagic diseases.
-
Huaihua, Flos Sophorae, is the dry flowers of S. japonica collected in summer when the plant has flowered. The rutin content in flowers should not be less than 8%. The medicinal indications of the flower are similar to those of flower buds for treatment of different hemorrhagic diseases.
-
Huaijiao, Fructus Sophorae, is the dry ripe fruits of S. japonica collected in winter. It is used for treatment of intestinal hemorrhage.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Shimizu M, Ohta G (1952) Solubilization of flavonoids. VIII. Glucosides in flos sophorae japonicae. J Pharm Soc Jpn 72:331–333
Schindler H (1954) Sophora japonica, an East Asian drug rich in rutin. The history of rutin. Dtsch Apoth Ztg 94:995–997
Karrer W (1976) Konstitution und Vorkommen der organischen Pflanzenstoffe, 2nd edn. Birkhäuser, Basel, pp 614–615
Foerster P (1882) Zur Identitätsfrage der Farbstoffe der chinesischen Gelbbeeren, der Kapern und der Raute mit dem Quercitrin und Quercetin. Chem Ber 15:214–217
Hlasiwetz H (1859) Ueber das Quercitrin. Liebigs Ann Chem 112:96–117
Kostanecki S, Tambor J (1895) Über die Constitution des Fisetins. Chem Ber 28:2302–2309
Attree GF, Perkin AG (1927) The position of the sugar nucleus in the quercetin glucosides. J Chem Soc 234–240
Tabata M (1975) Quantitative distribution of rutin in the panicles and flower organs of Sophora japonica. Shoyakugaku Zasshi 29:93–95
Balbaa SI, Zaki AY, El Shamy AM (1974) Total flavonoid and rutin content of the different organs of Sophora japonica. J Assoc Off Anal Chem 57:752–755
Kariyone T, Ishimasa S, Shiomi T (1956) Triterpenoids. VIII. Triterpenoids contained in Sophora japonica. J Pharm Soc Jpn 76:1210–1211
Kimura K, Takahashi M, Ishimasa S, Kodama Y (1958) Components of Sophora japonica. II. Structure of sophoradiol. Yakugaku Zasshi 78:1090–1094
Ishimasa S (1960) Components of Sophora japonica. III. Stereochemistry of sophoradiol. Yakugaku Zasshi 80:304–310
Clancy MJ (1960) Sophorose and its derivatives. J Chem Soc 4213–4217
Ho LX, Xu YX, Xue HZ, Wang WH, Zhou ZR, Chen PY, Fan MF (1982) Studies on the antifertility constituents of Huai Jiao. I. Isolation of constituents I-XI and identification of I-IV and IX. Reprod Contracept 2:23–27
Ho LX, Xu YX, Xue HZ (1984) Studies on antifertility constituents of Huai Jiao. II. Separation and identification of four compounds V-VIII. Reprod Contracept 4:51–53
Liu JS, Tiu CM, Huang MF (1980) Study on the active constituents of Sophora japonica L. Chin Trad Herb Drugs 11:145–146
Szabo V, Bognar R, Farkas E, Litkei G (1967) The glycosides of the fruit of Sophora japonica. VII. Acta Univ Debrecen Ludovico Kossuth Nominatae, Ser Phys Chim 13:129–144 (CA 69:16776t)
Charaux C, Rabate J (1938) Biochemical study of the fruits of Sophora japonica L. I. Presence of sophoricoside. Bull Soc Chim Biol 20:454–458
Zemplen G, Bognar R, Farkas L (1943) Determination of the structure of sophoricoside, an isoflavone glycoside of Sophora japonica L. Chem Ber 76B:267–272
Zemplen G, Bognar R (1942) Sophorabioside, an new glucoside from Sophora japonica. L. Chem Ber 75B:482–489
Farkas L, Nogradi M, Wagner H, Hoerhammer L (1968) Isoflavone glycosides. X. Final structure determination and total synthesis of sophorabioside, a glycoside from Sophora japonica. Chem Ber 101:2758–2761
Akhmedkhodzhaeva NM, Svechnikova AN, Bandyukova VA, Kambarova DM (1986) Determination of flavones in Sophora japonica fruits. Farmatsiya (Mosk) 35:60–61
Freudenberg K, Knauber H, Cramer F (1951) Die Übereinstimmung der Sophorose mit 2-(ß-Glucosido)-glucose. Chem Ber 84:144–146
Abdusalamov BA, Aslanov KA, Sadykov AS, Khoroshkova OA (1972) Level of alkaloids in Sophora japonica. Khim Prir Soedin 658
Komatsu M, Yokoe I, Shirataki Y (1976) Studies on the constituents of Sophora species. X. Constituents of the root of Sophora japonica L. Yakugaku Zasshi 96:254–257
Shibata S, Nishikawa Y (1963) Constituents of Japanese and Chinese crude drugs. VII. Constituents of the roots of Sophora subprostrata and Sophora japonica. Chem Pharm Bull (Tokyo) 11:167–177
Takeda T, Ishiguro I, Masegi M, Ogihara Y (1977) New isoflavone glycosides from the woods of Sophora japonica. Phy tochemistry 16:619–620
Stan HJ, Hunt W (1984) Flavonols — mutagens in our daily nutrition. Dtsch Lebensm Rundsch 80:85–87
Hardigree AA, Epier JL (1978) Comparative mutagenesis of plant flavonoids in microbial system. Mutat Res 58:231–239
Brown JP, Dietrich PS, Brown RJ (1977) Frameshift mutagenicity of certain naturally occurring phenolic compounds in the Salmonella/microsome test. Activation of anthraquinone and fla-vanol glycosides by gut bacterial enzymes. Biochem Soc Trans 5:1489–1492
Sugimura T, Minako M, Matsushima T, Yahagi T, Seino Y, Shirai A, Sawamura M, Natori S, Yoshihira K (1977) Mutagenicity of flavone derivatives. Proc Jpn Acad [B] 53:194–197
Brown JP, Dietrich PS (1979) Mutagenicity of plant flavonols in the Salmonella/mammalian microsome test. Activation of flavonol glycosides by mixed glycosidase from rat cecal bacteria and other sources. Mutat Res 66:223–240
Busch DB, Hatcher JF, Bryan GT (1986) Urine recovery experiments with quercetin and other mutagens using the Ames test. Environ Mutagen 8:393–399
Nagao M, Marita N, Yahagi T, Shimizu M, Kuroyanagi M, Fukuoka M, Yoshihara K, Natori S, Fujino T, Sugimura T (1981) Mutagenicities of 61 flavonoids and 11 related compounds. Environ Mutagen 3:401–419
MacGregor JT, Jurd L (1978) Mutagenicity of plant flavonoids: structural requirements for mutagenic activity in Salmonella typhimurium. Mutat Res 54:297–309
Hatcher JF, Bryon GT (1985) Factors affecting the mutagenic activity of quercetin for Salmonella typhimurium TA 98: metal ions, antioxidants and pH. Mutat Res 148:13–23
Friedman M, Smith GA (1984) Inactivation of quercetin mutagenicity. Food Chem Toxicol 22:535–539
Friedman M, Smith GA (1984) Factors which facilitate inactivation of quercetin mutagenicity. Adv Exp Med Biol 177:527–544
Meltz ML, MacGregor JT (1981) Activity of the plant flavonol quercetin in the mouse lymphoma L 5178y TK+/- mutation, DNA single-strand break and Balb/c3T3 chemical transformation assays. Mutat Res 88:317–324
Watson WAF (1982) The mutagenic activity of quercetin and kaempferol in Drosophila melanogaster. Mutat Res 103:145–147
Aeschbacher HU, Meier H, Ruch E (1982) Nonmutagenicity in vivo of the food flavonol quercetin. Nutr Cancer 4:90–98
Fukuhara Y, Yoshida D, Goto F (1981) Reduction of mutagenic products in the presence of polyphenols during pyrolysis of protein. Agric Biol Chem 45:1061–1066
Hang BQ, Wu Y, Hang S, Yang Y, Wang MS (1985) Effect of quercetin and rutin on the occurrence of micronuclei in mouse bone-marrow polychromatic erythrocytes. J Nanjing Coll Pharm 16:52–55
Huang MT, Wood AW, Newmark HL, Sayer JM, Yagi H, Jerina DM, Conney AH (1983) Inhibition of the mutagenicity of bay-region diol-epoxides of polycyclic aromatic hydrocarbons by phenolic plant flavonoids. Carcinogenesis 4:1631–1637
Ogawa S, Hirayama T, Nohara M, Tokuda M, Hirai K, Fukui S (1985) The effect of quercetin on the mutagenicity of 2-acetylaminofluorene and benz[a]-pyrene in Salmonella typhimurium strains. Mutat Res 142:103–107
Ogawa S, Hirayama T, Tokuda M, Hirai K, Fukui S (1986) The effect of quercetin, a mutagenic-ity-enhancing agent, on the metabolism of 2-acetylaminofluorene with mammalian metabolic activation systems. Mutat Res 162:179–186
Hirano I, Ueno I, Hosaka S, Takanashi H, Matsushima T, Sugimura T, Natori S (1981) Carcinogenicity examination of quercetin and rutin in ACI rats. Cancer Lett 13:15–21
Saito D, Shirai A, Matsushima T, Sugimura T, Hirono I (1980) Test of carcinogenicity of quercetin, a widely distributed mutagen in food. Teratogenesis Carcinog Mutagen 1:213–221
Morino K, Matsukura N, Kawachi T, Ohgaki H, Sugimura T, Hirono I (1982) Carcinogenicity test of quercetin and rutin in golden hamsters by oral administration. Carcinogenesis 3:93–97
Stoewsand GS, Anderson JL, Boyd JN, Hrazdina G, Babish JG, Walsh KM, Losco P (1984) Quercetin: a mutagen, not a carcinogen, in Fisher rats. J Toxicol Environ Health 14:105–114
Takanashi H, Aiso S, Hirono I, Matsushima T, Sugimura T (1983) Carcinogenicity test of quercetin and kaempferol in rats by oral administration. J Food Safety 5:55–60
Habs M, Habs H, Berger MR, Schmaehl D (1984) Negative dose-response study for carcinogenicity of orally administered rutin sulfate in Sprague-Dawley rats. Cancer Lett 23:103–108
Kato R, Nakadate T, Yamamoto S, Sugimura T (1983) Inhibition of 12-O-tetradecanoylphor-bol 13-acetate-induced tumor promotion and ornithine decarboxylase activity by quercetin: possible involvement of lipoxygenase inhibition. Carcinogenesis 4:1301–1305
Kato R, Nakadate T, Yamamoto S (1984) Involvement of lipoxygenase products of arachidonic acid in tumor-promoting activity of TPA. In: Thaler-Dao H, Crastes de Paulet A, Paoletti R (eds) Icosanoids Cancer. Raven, New York, pp 101–103
Nakadate T, Yamamoto S, Aizu E, Kato R (1984) 12-O-Tetradecanoylphorbol 13-acetate-caused increase in vascular permeability in mouse skin. II. Effects of caffeic acid derivatives, chalcone derivatives and calcium blockers on it. Ensho 4:554–556 (CA 102:99302c)
Nishino H, Nishino A, Iwashima A, Tanaka K, Matsuura T (1984) Quercetin inhibits the action of 12-O-tetradecanoylphorbol 13-acetate, a tumor promoter. Oncology 41:120–123
Gschwendt M, Kittstein W, Marks F (1984) Stimulation of alkaline phosphatase activity in mouse epidermis by tumor promoters. Cancer Lett 22:219–225
Fanning MJ, Macander P, Drzewiecki G, Middleton E Jr (1983) Quercetin inhibits anaphylactic contraction of guinea pig ileum smooth muscle. Int Arch Allergy Appl Immunol 71:371–373
Middleton E Jr, Drzewiecki G (1982) Effects of flavonoids and transitional metal cations on antigen-induced histamine release from human basophils. Biochem Pharmacol 31:1449–1453
Middleton E Jr, Drzewiecki G, Krishnarao D (1981) Quercetin: an inhibitor of antigen-induced human basophil histamine release. J Immunol 127:546–550
Michel F, Mercklein L, Rey R, Crastes de Paulet A (1986) Comparative effects of some flavonoids on cyclooxygenase and lipoxygenase activities in different cell systems or subfractions. Stud Org Chem (Amsterdam) 23:389–401
Van Wauwe J, Goosens J (1983) Effects of antioxidants on cyclooxygenase and lipoxygenase activities in intact human platelets: comparison with indomethacin and ETYA. Prostaglandins 26:725–730
Lanni C, Becker EL (1985) Inhibition of neutrophil phospholipase A2 by p-bromophenylacyl bromide, nordihydroguaiaretic acid, 5,8,11,14-eicosatetraenoic acid and quercetin. Int Arch Allergy Appl Immunol 76:214–217
Corvazier E, Maclouf J (1985) Interference of some flavonoids and nonsteroidal anti-inflammatory drug with oxidative metabolism and arachidonic acid by human platelets and neutrophils. Biochim Biophys Acta 835:315–321
Beretz A, Cazenave JP, Anton R (1982) Inhibition of aggregation and secretion and human platelets by quercetin and other flavonoids: structure-activity relationship. Agents Actions 12:382–387
Beretz A, Stierle A, Anton R, Cazenave JP (1982) Role of cyclic AMP in the inhibition of human platelet aggregation by quercetin, a flavonoid that potentiated the effect of prostacyclin. Biochem Pharmacol 31:3597–3600
Landolfi R, Mower RL, Steiner M (1984) Modification of platelet function and arachidonic acid metabolism by bioflavonoids. Structure-activity relationship. Biochem Pharmacol 33:1525–1530
Nishino H, Tanaka K, Matusura T (1983) Quercetin inhibits the aggregation of human platelets. Kyoto-furitsu Ika Daigaku Zasshi 92:165–168 (CA 98:191481p)
He SP, Wei MC, Li RZ, He YQ, Zhang RY, Chen YY, Yue BZ, Lu YX (1982) Study on the inhibitory effect of flavonoids in some traditional Chinese medicines on phosphodiesterase. J Beijing Med Coll 14:253–257
He SP, Qiao J (1985) The inhibition kinetic study of flavonoids on cAMP phosphodiesterase. Shenwu Huaxue Zazhi 1:55–58
He SP, Wei MC, Pei YQ, Wang XY (1984) Mechanism of cardiotonic effect of flavonoids from some traditional Chinese drugs. Hejishu 41–43
Basarker PW, Nath N (1983) Hypocholesterolemic and hypolipidemic activity of quercetin — a vitamin P-like compound in rats. Indian J Med Res 77:122–126
Kato N, Tosa N, Doudou T, Imamura T (1983) Effects of dietary quercetin on serum lipids. Agric Biol Chem 47:2119–2120
Shaikemeleva US (1983) Effect of rutin on cholesterol content in dog lymph, blood, and tissues. Byull Eksp Biol Med 95:53–57 (CA 98:196824n)
Ueno I, Nakano N, Hirono I (1983) Metabolic fate of 14C-quercetin in the ACI rat. Jpn J Exp Med 53:41–50
Gugler R, Leschik M, Dengler HJ (1975) Disposition of quercetin in man after single oral and intravenous doses. Eur J Clin Pharmacol 9:229–234
Baba S, Futura T, Fujioka M, Goromaru T (1983) Studies on drug metabolism by use of isotopes. XXVII. Urinary metabolites of rutin in rats and the role of intestinal microflora in the metabolism of rutin. J Pharm Sci 72:1155–1158
Griffiths LA, Brown S (1983) New metabolites of naturally occurring flavonols; identification by E.I. mass spectrometry and chromatographic techniques. Anal Chem Symp Ser 14:121 – 124
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 1992 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Tang, W., Eisenbrand, G. (1992). Sophora japonica L.. In: Chinese Drugs of Plant Origin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73739-8_114
Download citation
DOI: https://doi.org/10.1007/978-3-642-73739-8_114
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-73741-1
Online ISBN: 978-3-642-73739-8
eBook Packages: Springer Book Archive