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Daunomycin (Daunorubicin) and Adriamycin and Structural Analogues: Biological Activity and Mechanism of Action

  • Chapter
Mechanism of Action of Antimicrobial and Antitumor Agents

Part of the book series: Antibiotics ((ANTIBIOTICS,volume 3))

Abstract

Daunomycin (NSC-82151) is an antibiotic isolated from cultures of Streptomyces peucetius (DiMarco et al. 1963; DiMarco et al., 1964b). While weakly active against some microorganisms, the drug inhibits the multiplication of bacterial and animal viruses and exhibits a high cytotoxic activity against normal and neoplastic cells (Di Marco et al., 1964a).

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  1. A. Di Marco
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  2. F. Arcamone
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  3. F. Zunino
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Editors and Affiliations

  1. Department of Biochemistry, The Medical and Dental Schools, Northwestern University, 303 E. Chicago Avenue, Chicago, Illinois, 60611, USA

    John W. Corcoran Ph.D.

  2. Department of the Army, Walter Reed Army Institute of Research, Walter Reed Army Medical Center, Washington, D.C., 20012, USA

    Fred E. Hahn Ph.D.

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Di Marco, A., Arcamone, F., Zunino, F. (1975). Daunomycin (Daunorubicin) and Adriamycin and Structural Analogues: Biological Activity and Mechanism of Action. In: Corcoran, J.W., Hahn, F.E., Snell, J.F., Arora, K.L. (eds) Mechanism of Action of Antimicrobial and Antitumor Agents. Antibiotics, vol 3. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-46304-4_8

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