Abstract
Structural DNA nanotechnology utilizes key properties of DNA such as its persistence length and base pairing specificity to build molecularly identical architectures on the nanoscale. Of particular interest are the family of well-defined three-dimensional architectures including various polyhedra, boxes, tubes, and DNA-based dendrimers. Such scaffolded DNA architectures have recently been explored as nanoscale containers for functional molecules and as molecular breadboards to site specifically display the latter.
These DNA nanostructures have also been shown to interact specifically with cell-surface markers and trigger signaling pathways in a gamut of biological systems through specific targets. Such studies indicate the emerging potential of DNA structures in nanomedicine that could enable targeted delivery of molecular payloads within living systems.
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Acknowledgments
We thank all members of YK lab for their constructive inputs. DB thanks CSIR, GoI for research fellowship. YK thanks Wellcome Trust-DBT India Alliance, GoI for research funding and Department of Biotechnology, GoI for the Innovative Young Biotechnologist Award.
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Bhatia, D., Krishnan, Y. (2013). Designer Nucleic Acid-Based Devices in Nanomedicine. In: Erdmann, V., Barciszewski, J. (eds) DNA and RNA Nanobiotechnologies in Medicine: Diagnosis and Treatment of Diseases. RNA Technologies. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-36853-0_1
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DOI: https://doi.org/10.1007/978-3-642-36853-0_1
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