Skip to main content
SpringerLink
Log in

Alcohol Abuse in Adolescents: Relevance of Animal Models and Experimental Results in Adolescent Animals

  • Chapter
  • First Online:
Drug Abuse in Adolescence

  • 3147 Accesses

Abstract

This chapter reviews studies comparing the effects of drugs on adolescents and adults. The disorders associated with drug dependence usually start in adolescence or early adulthood. Among the significant consequences of drug use in adolescence is a higher risk of abuse and dependence in adulthood. The aim of this chapter is to describe the main studies on the behavioral, neuroanatomical, neurochemical, and functional differences between adolescents and adults and to correlate such differences with the higher vulnerability of adolescents to dependence. The hypothesis that adolescents might exhibit an idiosyncratic pattern of reactivity to ethanol that might expose them to higher risk of use/abuse, with alcohol also serving as a gateway for other drugs, is also assessed. The focus of this chapter is alcohol because it is one of the drugs most widely used by adolescents.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Johnston LD, O’Malley PM, Bachman JG, et al. Monitoring the future national results on adolescent drug use: overview of key findings, 2008. Bethesda: National Institute on Drug Abuse; 2009.

    Google Scholar 

  2. Galduroz JC, Carlini EA. Use of alcohol among the inhabitants of the 107 largest cities in Brazil, 2001. Braz J Med Biol Res. 2007;40:367–75.

    Article  PubMed  Google Scholar 

  3. Alderete E, et al. Problemas relacionados con el consumo de alcohol en jóvenes de la provincia de Jujuy, Argentina. Salud Pub Mex. 2008;50(4):300–7.

    Article  Google Scholar 

  4. Rojas-Guiot E, et al. Alcohol and drug consumption among students in Pachuca, Hidalgo. Salud Pub Mex. 1999;41(4):297–308.

    Article  Google Scholar 

  5. Noal RB, et al. Experimental use of alcohol in early adolescence: the 11-year follow-up of the 1993 Pelotas (Brazil) birth cohort study. Cad Saúde Pub. 2010;26(10):1937–44.

    Article  Google Scholar 

  6. Grant BF, Dawson DA. Age at onset of alcohol use and its association with DSM-IV alcohol abuse and dependence: results from the National Longitudinal Alcohol Epidemiologic Survey. J Subst Abuse. 1997;9:103–10.

    Article  PubMed  Google Scholar 

  7. DeWit DJ, et al. Age at first alcohol use: a risk factor for the development of alcohol disorders. Am J Psychiatr. 2000;157:745–50.

    Article  PubMed  Google Scholar 

  8. Dawson D, Grant A, Bridget F, et al. Impact of age at first drink on stress-reactive drinking. Alcohol Clin Exp Res. 2007;31(1):69–77.

    Article  PubMed  Google Scholar 

  9. Fernández-Vidal JM, Molina JC. Socially mediated alcohol preferences in adolescent rats following interactions with an intoxicated peer. Pharmacol Biochem Behav. 2004;79(2):229–41.

    Article  PubMed  Google Scholar 

  10. Pautassi RM, et al. Ethanol induces second-order aversive conditioning in adolescent and adult rats. Alcohol (NY). 2011;45(1):45–55.

    Article  Google Scholar 

  11. Hunt PS, Holloway JL, Scordalakes EM. Social interaction with an intoxicated sibling can result in increased intake of ethanol by periadolescent rats. Develop Psychobiol. 2001;38:101–9.

    Article  Google Scholar 

  12. Bell RL, et al. The alcohol-preferring P rat and animal models of excessive alcohol drinking. Addict Biol. 2006;11(3–4):270–88.

    Article  PubMed  Google Scholar 

  13. Pautassi RM, et al. Ontogeny of ethanol intake in alcohol preferring (P) and alcohol nonpreferring (NP) rats. Develop Psychobiol. 2011;53(3):234–45.

    Article  Google Scholar 

  14. Pascual M, et al. Repeated alcohol administration during adolescence causes changes in the mesolimbic dopaminergic and glutamatergic systems and promotes alcohol intake in the adult rat. J Neurochem. 2009;108(4):920–31.

    Article  PubMed  Google Scholar 

  15. Hargreaves GA, Monds L, Gunasekaran N, et al. Intermittent access to beer promotes binge-like drinking in adolescent but not adult Wistar rats. Alcohol. 2009;43(4):305–14.

    Article  PubMed  Google Scholar 

  16. Casey BJ, et al. The adolescent brain. Dev Rev. 2008;28:62–77.

    Article  PubMed Central  PubMed  Google Scholar 

  17. Kelly SJ, Bonthius DJ, West JR. Developmental changes in alcohol pharmacokinetics in rats. Alcohol Clin Exp Res. 1987;1:281–6.

    Article  Google Scholar 

  18. Pautassi RM, et al. Adolescent but not adult rats exhibit ethanol-mediated appetitive second-order conditioning. Alcohol Clin Exp Res. 2008;32(11):2016–27.

    PubMed Central  PubMed  Google Scholar 

  19. Varlinskaya EI, Spear LP. Acute effects of ethanol on social behavior of adolescent and adult rats: role of familiarity of the test situation. Alcohol Clin Exp Res. 2002;26:1502–11.

    Article  PubMed  Google Scholar 

  20. Anderson RI, Varlinskaya EI, Spear LP. Ethanol-induced conditioned taste aversion in male sprague-dawley rats: impact of age and stress. Alcohol Clin Exp Res. 2010;34(12):2106–15.

    Article  PubMed Central  PubMed  Google Scholar 

  21. Alfonso-Loeches S, Guerri C. Molecular and behavioral aspects of the actions of alcohol on the adult and developing brain. Crit Rev Clin Lab Sci. 2001;48:19–47.

    Article  Google Scholar 

  22. Laviola G, et al. Risk-taking behavior in adolescent mice: psychobiological determinants and early epigenetic influence. Neurosci Biobehav Rev. 2003;27:19–31.

    Article  PubMed  Google Scholar 

  23. Teicher M, Andersen SL, Hostetter Jr JC. Evidence for dopamine receptor pruning between adolescence and adulthood in striatum but not nucleus accumbenus. Dev Brain Res. 1995;89:167–72.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pharmacology, Institute of Biomedical Sciences, USP, São Paulo, Brazil

    Rosana Camarini

  2. National Council of Scientific and Technological Research, Buenos Aires, Argentina

    Ricardo M. Pautassi

  3. Department of Psychology, National University of Córdoba, Córdoba, Argentina

    Ricardo M. Pautassi

Authors
  1. Rosana Camarini
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ricardo M. Pautassi
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Rosana Camarini .

Editor information

Editors and Affiliations

  1. Universidade Federal de Sao Paulo, São Paulo, Brazil

    Denise De Micheli

  2. Universidade Anhembi Morumbi, São Paulo, Brazil

    André Luiz Monezi Andrade

  3. Universidade Federal de Sao Paulo, São Paulo, Brazil

    Eroy Aparecida da Silva

  4. Universidade Federal de Sao Paulo, São Paulo, Brazil

    Maria Lucia Oliveira de Souza Formigoni

Rights and permissions

Reprints and permissions

Copyright information

© 2016 Springer International Publishing Switzerland

About this chapter

Cite this chapter

Camarini, R., Pautassi, R. (2016). Alcohol Abuse in Adolescents: Relevance of Animal Models and Experimental Results in Adolescent Animals. In: De Micheli, D., Andrade, A., da Silva, E., de Souza Formigoni, M. (eds) Drug Abuse in Adolescence. Springer, Cham. https://doi.org/10.1007/978-3-319-17795-3_7

Download citation

Publish with us

Policies and ethics

Search

Navigation