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Aetiology and Clinical Features of Crohn’s Disease

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Crohn's Disease

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Abstract

The aetiology of Crohn’s disease is largely unknown, but probably involves a combination of genetic, immunological and environmental factors. This chapter describes the incidence of Crohn’s disease and the methodological approaches used to investigate the aetiology. Exposures which could influence the risk of Crohn’s disease are discussed, including genetics, smoking, habitual diet, the gut microbiota and commonly prescribed medications, including non-steroidal anti-inflammatory drugs and oral contraceptives. An overview of the clinical features of Crohn’s disease is also presented.

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Authors and Affiliations

  1. Department of Gastroenterology, Norfolk and Norwich University Hospital, Norwich, NR4 7UY, UK

    Simon S. M. Chan MB BChir, PhD & Andrew R. Hart MB ChB, MD

  2. Norwich Medical School, University of East Anglia, Norwich Research Park, Norwich, NR4 7TJ, UK

    Simon S. M. Chan MB BChir, PhD & Andrew R. Hart MB ChB, MD

Authors
  1. Simon S. M. Chan MB BChir, PhD
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  2. Andrew R. Hart MB ChB, MD
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Correspondence to Simon S. M. Chan MB BChir, PhD .

Editor information

Editors and Affiliations

  1. University Hospitals of Leicester NHS Trust, Leicester, United Kingdom

    Arumugam Rajesh

  2. Department of Radiology, Warwick Hospital, Warwick, United Kingdom

    Rakesh Sinha

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© 2015 Springer International Publishing Switzerland

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Chan, S.S.M., Hart, A.R. (2015). Aetiology and Clinical Features of Crohn’s Disease. In: Rajesh, A., Sinha, R. (eds) Crohn's Disease. Springer, Cham. https://doi.org/10.1007/978-3-319-01913-0_1

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  • DOI: https://doi.org/10.1007/978-3-319-01913-0_1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-01912-3

  • Online ISBN: 978-3-319-01913-0

  • eBook Packages: MedicineMedicine (R0)

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